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Preparation method of danshen root wall-broken decoction pieces for treating chest obstruction colic and stomach duct and abdomen pain, and danshen root wall-broken decoction pieces prepared by method

A technology of broken-wall decoction pieces and southern salvia miltiorrhiza, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, non-central analgesics, etc., can solve the problems of not being widely used and not forming industry standards, and achieve good composition consistency , Conducive to the development of modern large-scale industrialization, the effect of stable quality

Inactive Publication Date: 2019-03-29
JIANGXI GROUNDIONG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the broken-wall decoction piece technology is not widely used in domestic decoction piece production enterprises, and no real industry norms have been formed.
Therefore, research and development of a preparation method of broken Chinese medicine decoction pieces, give full play to the advantages of using the whole ingredients of Chinese medicine broken wall decoction pieces, retain all the medicinal ingredients of traditional Chinese medicine by breaking the wall, which is more conducive to the absorption of medicinal ingredients by users , in order to alleviate the problem that the existing traditional Chinese medicine granules can only extract part of the medicinal ingredients after adding water to concentrate, it becomes very necessary and urgent
However, there is no report about the broken wall decoction pieces of Southern Salvia Miltiorrhiza and its preparation process

Method used

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  • Preparation method of danshen root wall-broken decoction pieces for treating chest obstruction colic and stomach duct and abdomen pain, and danshen root wall-broken decoction pieces prepared by method
  • Preparation method of danshen root wall-broken decoction pieces for treating chest obstruction colic and stomach duct and abdomen pain, and danshen root wall-broken decoction pieces prepared by method

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preparation example Construction

[0019] The preparation method of the broken wall decoction pieces of southern salvia miltiorrhiza of the present invention comprises the following steps:

[0020] (1) Pre-crushing the dried southern salvia miltiorrhiza medicinal material to obtain southern salvia miltiorrhiza medicinal material granules with a particle size of 10-100 mesh;

[0021] (2) Soaking the granules of the southern salvia miltiorrhiza medicinal material with 30-60% by weight of ethanol aqueous solution, the soaking conditions include: the temperature is 40-60°C, and the time is 1-3 hours;

[0022] (3) Filtrate, freeze-dry the obtained filter cake, the conditions of freeze-drying include: temperature is -10 ℃~-50 ℃, vacuum degree is 5-50Pa;

[0023] (4) Place the freeze-dried southern salvia miltiorrhiza granules at a temperature of -10°C to 0°C for 1-3 hours;

[0024] (5) placing the obtained southern salvia miltiorrhiza granules under vacuum conditions for microwave treatment;

[0025] (6) Superfinel...

Embodiment 1

[0041] (1) Take 2.0kg of southern salvia miltiorrhiza medicinal material, pre-crushed to a particle size of 50 mesh, then add 4 times the volume of southern salvia miltiorrhiza granules in 45% by weight ethanol solution, soak at 50°C for 2 hours, and filter with 200 mesh stainless steel wire mesh , The resulting filter cake was freeze-dried at -20°C under a vacuum of 30 Pa. After the southern salvia miltiorrhiza granules were dried, they were placed at -5°C for 2 hours.

[0042] (2) Place the southern salvia miltiorrhiza granules obtained in step (1) under vacuum conditions for microwave treatment. The microwave treatment conditions are: temperature is 25°C, time is 30min, microwave power is 15kW, and vacuum degree is 15Pa.

[0043] (3) Using a CW5-100QA wall-breaking ultrafine pulverizer to ultrafinely pulverize the southern salvia miltiorrhiza granules obtained in step (2), to obtain ultrafine powder with a particle size of 5-30 microns.

[0044] (4) Mix the ultrafine powde...

Embodiment 2

[0046] (1) Take 2.0kg of southern salvia miltiorrhiza medicinal material, pre-crushed to a particle size of 100 mesh, then add 4 times the volume of the southern salvia miltiorrhiza granules in 35% by weight ethanol solution, soak at 45°C for 2 hours, and filter with a 200 mesh stainless steel mesh , The resulting filter cake was freeze-dried at -20°C under a vacuum of 30 Pa. After the southern salvia miltiorrhiza granules were dried, they were placed at -5°C for 2 hours.

[0047] (2) Place the southern salvia miltiorrhiza granules obtained in step (1) under vacuum conditions for microwave treatment. The microwave treatment conditions are: temperature is 25°C, time is 30min, microwave power is 15kW, and vacuum degree is 15Pa.

[0048] (3) Using a CW5-100QA wall-breaking ultrafine pulverizer to ultrafinely pulverize the southern salvia miltiorrhiza granules obtained in step (2), to obtain ultrafine powder with a particle size of 5-30 microns.

[0049] (4) Mix the ultrafine powde...

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Abstract

The invention relates to the technical field of traditional Chinese medicine wall-broken decoction pieces, and discloses a preparation method of danshen root wall-broken decoction pieces for treatingchest obstruction colic and stomach duct and abdomen pain, and the danshen root wall-broken decoction pieces prepared by the method. The method comprises the following steps: (1) pre-pulverizing a medicinal material of dried danshen roots; (2) soaking the obtained danshen root medicinal material granules in an ethanol aqueous solution; (3) performing filtration, and freeze-drying the obtained filter cakes; (4) standing the freeze-dried danshen root granules at a temperature of -10 to 0 DEG C for 1-3 hours; (5) carrying out microwave treatment on the obtained danshen root granules under a vacuum condition; (6) carrying out superfine grinding on the microwave-treated danshen root particles; and (7) mixing the obtained superfine powder with an ethanol aqueous solution, and then performing granulation and drying. The danshen root wall-broken decoction pieces with high wall-breaking ratio can be prepared by adopting the method disclosed by the invention.

Description

technical field [0001] The invention relates to the technical field of broken-wall decoction pieces of traditional Chinese medicine, in particular to a preparation method of broken-wall decoction pieces of southern salvia miltiorrhiza for treating chest pain and abdominal pain and the broken-wall decoction pieces of southern salvia miltiorrhiza prepared therefrom. Background technique [0002] Broken-wall decoction pieces of traditional Chinese medicine is a traditional Chinese medicine decoction piece processed in powder form by using modern ultrafine pulverization technology. Broken wall decoction pieces of traditional Chinese medicine are all ingredients used as medicine, and the medicinal material basis remains unchanged, which is in line with the connotation of Chinese medicine decoction pieces. It can be directly brewed and taken together with the dregs of the medicine. However, the broken-wall decoction pieces technology is not widely used in domestic decoction piece...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/16A61P9/10A61P25/20A61P9/06A61P1/00A61P29/00A61P15/00A61P7/04A61P19/02A61P43/00A61P17/02A61K125/00
CPCA61K9/1623A61K36/537A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61P1/00A61P7/04A61P9/06A61P9/10A61P15/00A61P17/02A61P19/02A61P25/20A61P29/00A61P43/00
Inventor 眭荣春廖年生杨健平
Owner JIANGXI GROUNDIONG PHARM CO LTD
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