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Blood sample-free tumor early detection method

A tumor and blood sample technology, applied in the field of monitoring, can solve the problems of human pain, discomfort, missing the best time for breast cancer screening, etc., and achieve the effect of good reproducibility and high detection sensitivity

Inactive Publication Date: 2019-03-12
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Generally speaking, blood tests also require tumor cells to gather in a large number in breast cancer and some of them fall off into blood vessels and start to spread before they can be found through blood tests. Secondly, this method of taking blood for testing often causes pain to people. In practice, many people avoid blood tests because they are afraid of the process of drawing blood, and finally miss the best period for breast cancer screening

Method used

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  • Blood sample-free tumor early detection method
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  • Blood sample-free tumor early detection method

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Embodiment 1

[0025] (1) Dissolve 4.0 g of HA in 200 mL of deionized water and continuously stir overnight at 4 °C, then add 133.3 mL of DMF and 4.76 mL of MA dropwise into the solution, and adjust the pH of the solution to pH 8 with 1M NaOH , stirred continuously at -4 °C for 18 hours, subsequently, 9.88 g NaCl was added to the reaction solution, and then MeHA was precipitated in ethanol, the precipitate was washed with ethanol three times, then dissolved in deionized water, and the solution was dialyzed in deionized water for 7 The purified product was obtained by lyophilization.

[0026] (2) Methacrylated hyaluronic acid (50mg mL -1 ) and photoinitiator (Irgacure 2959, 0.5mg mL -1 ) was dissolved in pure water, and the mixture was poured into a plasma-treated PDMS mold until it was filled, and then the PDMS mold was centrifuged at 4000 rpm for 3 minutes. Additional mixture solution was added to produce a firm backing, and after drying in a fume hood at room temperature for 12 h, the cr...

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Abstract

The invention discloses a blood sample-free tumor early detection method. The blood sample-free tumor early detection method comprises the following two steps of performing painless extraction on skinbod fluids of a suspected tumor-bearing part with a crosslinked polymer soft microneedle patch or a metal rigid microneedle; synthesizing a Ag3PO4 / Ag nanocomposite material and structuring sandwich type colorimetric immunoassay based on a Fe3O4@Ag magnetic platform to detect CEA (carcinoembryonic antigen) in the body fluids. The blood sample-free tumor early detection method can help extract theskin body fluids rapidly and painlessly, and compared with classic blood sample analysis, can help find tumor cells earlier and save operation by professionals, is simple, applicable to semi-alignmentscreening of breast cancer, high in detection sensitivity to carcinoembryonic antigens, and good in reproducibility.

Description

technical field [0001] The invention belongs to the field of monitoring, and in particular relates to a method for early monitoring of blood-like tumors. Background technique [0002] Breast cancer is one of the most common malignant tumors in women, and its incidence rate accounts for 7-10% of all kinds of malignant tumors in the whole body, showing an increasing trend year by year. Now it ranks first among female malignant tumors. About 1.2 million women in the world develop breast cancer every year, and 500,000 die from the disease. Early breast cancer often does not have typical symptoms and signs, and it is not easy to attract attention. Generally, it is found in the late stage, but the late symptoms are more serious, easy to transfer, easy to relapse, low cure rate, high mortality, poor prognosis, and affect normal life. Therefore, early diagnosis of breast cancer is the key to breast cancer treatment. Currently, breast cancer treatment methods include breast self-exa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574
CPCG01N33/57415G01N2800/365G01N2800/7028
Inventor 王小磊陈丽名张翠翠
Owner NANCHANG UNIV
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