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Ophthalmic drug composition, and preparation method and application thereof

A composition and drug technology, applied in the field of ophthalmic preparations, can solve problems such as poor drug compliance, vascular blood pressure rebound, eye pain, etc., to achieve the effect of reducing irritation, reducing side effects, and improving therapeutic effect

Active Publication Date: 2019-03-12
湖北远大天天明制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, naphazoline is an adrenal receptor agonist, which has the effect of shrinking eye capillaries, so it has a good effect on conjunctival congestion. Chlorpheniramine and vitamin B12 can reduce eye allergy symptoms and maintain ocular nerve function respectively. However, after patients stop using Naminwei Eye Drops for a long time, the blood pressure of the contracted blood vessels will rebound, resulting in eye pain, which will lead to poor drug compliance of patients

Method used

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  • Ophthalmic drug composition, and preparation method and application thereof
  • Ophthalmic drug composition, and preparation method and application thereof
  • Ophthalmic drug composition, and preparation method and application thereof

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preparation example Construction

[0024] The present invention also provides a preparation method of an ophthalmic pharmaceutical composition, comprising the following steps:

[0025] Firstly, the dosage of each substance is calculated according to the formula, and then the vitamin B12 powder is mixed with water for injection to obtain a vitamin B12 solution.

[0026] Mix and dissolve taurine with an appropriate amount of injection water to ensure that each material can be mixed evenly, and ensure that taurine can be fully mixed with naphazoline hydrochloride, vitamin B12 and chlorpheniramine to ensure synergistic effect .

[0027] Add an appropriate amount of injection water into the reactor, and raise the temperature to 60-80°C to heat the injection water to increase the solubility of each substance and facilitate the uniform mixing of each substance. Then mix with osmotic pressure regulator, metal ion complexing agent and pH regulator, and then mix with naphazoline hydrochloride, chlorpheniramine, vitamin ...

Embodiment 1

[0032] The present embodiment provides a kind of ophthalmic pharmaceutical composition (1000mL), and it comprises 0.05g naphazoline hydrochloride, 3.2g taurine, 0.1g boric acid, 0.05g glycerin, 0.01g edetate disodium, 0.2g vitamin B12 and 0.1g chlorpheniramine.

[0033] This embodiment also provides a preparation method of ophthalmic pharmaceutical composition:

[0034] Dissolving vitamin B12 powder in water for injection to obtain vitamin B12 solution;

[0035] Taurine is dissolved in water for injection to obtain a taurine solution;

[0036] Add an appropriate amount of water for injection into the reactor and raise the temperature to 70°C, then mix with boric acid, glycerin and edetate disodium, then mix with naphazoline hydrochloride, chlorpheniramine maleate, and then mix with vitamin B12 solution and taurine The acid solutions were mixed, then kept at 70°C, stirred for 30 minutes, then cooled, and water for injection was added to make up to volume.

Embodiment 2-6

[0038] The ophthalmic pharmaceutical composition provided by embodiment 2-6 is the same as the raw material of the ophthalmic pharmaceutical composition provided by embodiment 1, the difference is that the specific dosage is different; the preparation method of the ophthalmic pharmaceutical composition provided by embodiment 2-6 is the same as that of embodiment 1 1 The preparation method of the ophthalmic pharmaceutical composition provided is basically the same, the difference lies in the different operating conditions.

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Abstract

The invention relates to the field of ophthalmic preparations, in particular to an ophthalmic drug composition, and a preparation method and application thereof. The composition per 1000 ml is prepared from 0.05 to 0.15 g of naphazoline hydrochloride, 3.2 to 5.8 g of taurine, 0.1 to 0.3 g of pH adjuster, 0.05 to 0.15 g of osmotic pressure regulator, 0.01 to 0.05 g of metal ion complexing agent, 0.2 to 0.5 g of vitamin B12 and 0.1 to 0.3 g of chlorpheniramine. Taurine, naphazoline hydrochloride, vitamin B12 and chlorpheniramine together perform synergistic interaction to improve the treatment effect of the ophthalmic drug composition on conjunctivitis, achieve a good treatment effect on hyperemia, edema, and the like caused by inflammation, and also can significantly reduce the side effectsof the composition, reduce the stimulation of the composition on the eye, and enhance the experience of a patient in medication.

Description

technical field [0001] The invention relates to the field of ophthalmic preparations, in particular to an ophthalmic pharmaceutical composition, a preparation method and application thereof. Background technique [0002] Naminwei Eye Drops is an ophthalmic over-the-counter drug that can be used to relieve symptoms such as eye fatigue, conjunctival congestion, and itchy eyes. Among them, naphazoline is an adrenal receptor agonist, which has the effect of shrinking eye capillaries, so it has a good effect on conjunctival congestion. Chlorpheniramine and vitamin B12 can reduce eye allergy symptoms and maintain ocular nerve function respectively. However, after the patient stops using Naminwei eye drops for a long time, the blood pressure of the contracted blood vessels will rebound, resulting in eye pain, which will lead to poor drug compliance of the patient. Contents of the invention [0003] The purpose of the present invention is to provide an ophthalmic pharmaceutical c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/185A61K31/4174A61K31/4402A61K31/714A61P27/02
CPCA61K31/185A61K31/4174A61K31/4402A61K31/714A61P27/02A61K2300/00
Inventor 付欢王超尹传忠万利鹏延静
Owner 湖北远大天天明制药有限公司
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