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Method for synthesizing phenylalanine esterified bagasse xylan-g-CHMA (cyclohexyl methacrylate) with anti-tumor activity

A technology of phenylalanine ester and synthesis method, which is applied in the field of synthesizing anticancer activity phenylalanine esterified bagasse xylan-g-CHMA, can solve the problems of being insoluble in water, restricting application and the like, and achieves enhanced biological The effect of activity, high grafting rate and broad application prospects

Inactive Publication Date: 2019-03-08
GUILIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] Xylan has functional activities such as improving immunity and anti-tumor, but because it contains a large number of hydroxyl groups, it is easy to form intramolecular and intermolecular hydrogen bonds, and it is difficult to dissolve in water, which seriously restricts its application. Therefore, it is necessary to modify it. sex

Method used

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  • Method for synthesizing phenylalanine esterified bagasse xylan-g-CHMA (cyclohexyl methacrylate) with anti-tumor activity
  • Method for synthesizing phenylalanine esterified bagasse xylan-g-CHMA (cyclohexyl methacrylate) with anti-tumor activity
  • Method for synthesizing phenylalanine esterified bagasse xylan-g-CHMA (cyclohexyl methacrylate) with anti-tumor activity

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Experimental program
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Embodiment

[0038] (1) Put 5 g of bagasse xylan in a constant-temperature vacuum oven at 60° C. and dry for 24 hours to constant weight to obtain dry-based bagasse xylan.

[0039] (2) Measure 10 mL of analytically pure N-methylimidazole and 12 mL of analytically pure chloroethanol into a 250 mL four-neck flask, stir and react at 70° C. for 24 hours, and cool down to room temperature.

[0040] (3) Place the material obtained in step (2) in a refrigerator at 5°C for 10 hours to precipitate a precipitate, wash it with 15mL of analytically pure ethyl acrylate, and filter it with suction three times, put the filter cake in a watch glass, and place it in a constant vacuum at 45°C Dry in a drying oven for 24 hours to obtain 1-(2-hydroxyethyl)-3-methylimidazole chloride ([Hemim]Cl), a solid ionic liquid at room temperature.

[0041] (4) Weigh 0.3g of ammonium persulfate into a 50mL beaker, add 15mL of analytically pure dimethyl sulfoxide (DMSO), stir at 20°C to obtain a mixed solution of initiato...

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Abstract

The invention discloses a method for synthesizing phenylalanine esterified bagasse xylan-g-CHMA with anti-tumor activity. The method comprises taking bagasse xylan as the raw material, and in an ionicliquid of [Hemim]Cl, taking ammonium persulfate as an initiator and cyclohexyl methacrylate as grafting monomers to synthesize a bagasse xylan-g-CHMA derivative; taking Boc-L-phenylalanine as esterification agent and 4-dimethylaminopyridine as catalysts for catalytic esterification in ionic liquid solvent to synthesize a bagasse xylan esterified grafted derivative phenylalanine esterified bagassexylan-g-CHMA; performing deprotection through trifluoroacetic acid to obtain the product of the phenylalanine esterified bagasse xylan-g-CHMA. Under the reaction environment of the ionic liquid, themethod for synthesizing the phenylalanine esterified bagasse xylan-g-CHMA with the anti-tumor activity introduces active groups to the main chain and the side chain of bagasse xylan through grafting and esterification reaction, thereby enhancing the bioactivity of raw bagasse xylan; the prepared phenylalanine esterified bagasse xylan-g-CHMA has a broad application prospect in the fields of biologyand medicine.

Description

technical field [0001] The invention relates to the technical field of fine chemicals, in particular to a method for synthesizing anticancer active phenylalanine esterified bagasse xylan-g-CHMA in ionic liquid. Background technique [0002] Xylan has functional activities such as improving immunity and anti-tumor, but because it contains a large number of hydroxyl groups, it is easy to form intramolecular and intermolecular hydrogen bonds, and it is difficult to dissolve in water, which seriously restricts its application. Therefore, it is necessary to modify it. sex. As a new type of green solvent, ionic liquid has good solubility for various organic and inorganic macromolecular substances, and can be used as a medium for physical and chemical modification of polysaccharides. [0003] The physical and chemical properties of bagasse xylan are often enhanced by chemical modification methods such as esterification and grafting. Cyclohexyl methacrylate (CHMA) is an unsaturate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F251/00C08F220/18A61P35/00
CPCA61P35/00C08F251/00C08F220/1806Y02P20/54
Inventor 李和平耿恺柴建啟张淑芬武晋雄龚俊张俊
Owner GUILIN UNIVERSITY OF TECHNOLOGY
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