Dual-modal endoscope device based on liquid lens self-focusing

Abstract

The invention provides a dual-modal endoscope device based on liquid lens self-focusing. The dual-modal endoscope device based on liquid lens self-focusing comprises a shell and a rotary scanning cavity arranged in the shell and provided with a reflector. The rotary scanning cavity receives exciting light and outputs an OCE signal and a fluorescence signal reflected by a sample respectively through a single-mode optical fiber and a multi-mode optical fiber to achieve panoramic scanning. The OCE and FLE technologies are integrated, the structure and functions of the interior of an organism aresubjected to real-time high-resolution varifocal imaging, a precise and effective morphological structure information image is provided for early detection for precisely monitoring gastrointestinal tract system diseases, and meanwhile quantitative optical coherence and fluorescence two-dimensional and three-dimensional dual-modal images with high sensitivity and high specificity are given.

Description

technical field [0001] The present invention relates to a technology in the field of medical equipment, specifically a dual-mode endoscope device based on liquid lens self-focusing, which adopts double-clad optical fiber to realize high-sensitivity and high-specificity fluorescence endoscopic imaging, and at the same time It can realize automatic focusing optical coherent imaging of complex irregular structure organisms. It is an endoscope with automatic focusing characteristics that integrates two imaging modalities. Background technique [0002] At present, optical endoscopy has been commonly used in clinical disease detection. For example, fluorescence endoscopy uses exogenous fluorescent molecular probes to target target organisms to achieve molecular functional high-sensitivity imaging. Structural imaging, especially three-dimensional imaging of tissue tomography, has limitations. Optical coherence tomography (OCE), based on the measurement of optical weak coherent bac...

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Problems solved by technology

However, in the existing multimodal endoscopy technologies such as fluorescence and photoacoustic endoscopy, although the fluorescence mode can realize the detection and imaging of fluorescence signals of early tissue lesions, it lacks morphological structure information and has low resolution to distinguish lesion groups. The fine features of the part; although the photoacoustic endoscopic microscope can improve the image resolution, but the imaging depth has a certain limit; at the same time, due to the surface inhomogeneity of the intestinal tissue, the focal point of the probe beam is defocused and the image distortion

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