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Method for determining lansoprazole content based on single-sweep polarographic analysis

A technology for lansoprazole and a determination method, which is applied in the field of chemical analysis, can solve the problems that the determination method is not fast and accurate, and the content and related substance inspection methods are different, and achieves the effects of simple operation, high sensitivity and high recovery rate.

Inactive Publication Date: 2019-02-22
HUNAN INSTITUTE OF ENGINEERING
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] "Chinese Pharmacopoeia" 2005 Edition (Part II) is not included, "EP 6.0" and "USP 30" have testing methods for this substance, but the content and testing methods of related substances are different, generally speaking, the testing methods are the same. not fast enough

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  • Method for determining lansoprazole content based on single-sweep polarographic analysis
  • Method for determining lansoprazole content based on single-sweep polarographic analysis
  • Method for determining lansoprazole content based on single-sweep polarographic analysis

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Embodiment Construction

[0017] The present invention will be further described below in conjunction with the drawings and examples.

[0018] In this embodiment, 2.70×10 -4 The preparation steps of mol / L lansoprazole standard solution include: accurately weigh 0.1005g lansoprazole in a 40mL small beaker, dissolve it with 40mL pure methanol, transfer it to a 100mL volumetric flask, and add double distilled water to make the volume constant. Formulated into 2.70×10 -4 mol / L Lansoprazole standard solution, then pour it into a brown bottle and place it in the refrigerator for storage.

[0019] Use double distilled water to gradually dilute to 2.70×10 -5 mol / L, 2.70×10 -6 mol / L, 2.70×10 - 7 mol / L, 2.70×10 -8 mol / L, 2.70×10 -9 mol / L Lansoprazole standard solution.

[0020] Saturated borax solution: Weigh a certain quality of borax and prepare it into a saturated borax solution.

[0021] The rest of the reagents are analytically pure, prepared by conventional methods, and the experimental water is double distilled w...

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Abstract

The invention discloses a method for determining lansoprazole content based on single-sweep polarographic analysis. The method includes obtaining a linear relationship between peak current and lansoprazole concentration obtained by the single-sweep polarographic analysis; providing a polarograph; adding a sample solution to be tested and a saturated borax base solution to a container, shaking, transferring to a polarograph electrolytic cell for linear sweeping to obtain the peak current; obtaining the concentration of the sample solution to be tested from the peak current according to the linear relationship and further obtaining the lansoprazole content. The method for determining the lansoprazole content is based on the single-sweep polarographic analysis. According to the linear relationship between the peak current and the lansoprazole concentration, the concentration of the sample solution to be tested is obtained from the peak current, and the lansoprazole is further obtained. The method has high sensitivity and good accuracy and precision, is easy to operate and high in recovery rate, and can be used for determining the lansoprazole content in certain drug capsules or tablets.

Description

Technical field [0001] The invention relates to a chemical analysis method, in particular to a lansoprazole content determination method based on a single-scan polarographic analysis method. Background technique [0002] Lansoprazole (C 16 H 14 F 3 N 3 O 2 S) Alias ​​"duckprolon", the chemical name is (±)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl ]-Sulfinyl]-1H-benzimidazole. The English name is "LansoprazoleCapsules" or "Takepron", the trade name is The drug category is antacids and anti-ulcer drugs, and is a new generation of proton pump inhibitors after omeprazole. It has the characteristics of unique mechanism of action, high specificity, strong action, and lasting action time. The pharmacological effect of lansoprazole is to significantly inhibit the secretion of basic gastric acid and gastric acid caused by all irritants, and its inhibitory effect is significantly better than that of H2 receptor blockers. Lansoprazole tablets are mainly used as a new type...

Claims

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Application Information

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IPC IPC(8): G01N27/48
CPCG01N27/48
Inventor 陈立新李飒爽
Owner HUNAN INSTITUTE OF ENGINEERING
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