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Vegetable anti-allergic agent stock solution and preparation method and application thereof

Inactive Publication Date: 2019-02-12
甘肃泛植制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the current plant-based antisensitizers added in cosmetics have the disadvantages of deep color and heavy odor due to their simple extraction process and extensive methods, and the customer experience is poor, so their use is limited; Most of the added botanical antisensitizers are a single component, and the antisensitivity effect is not good

Method used

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  • Vegetable anti-allergic agent stock solution and preparation method and application thereof
  • Vegetable anti-allergic agent stock solution and preparation method and application thereof
  • Vegetable anti-allergic agent stock solution and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The botanical antisensitizer stock solution FZ AW-101 of this embodiment is mixed by the following components:

[0049] Dipotassium glycyrrhizinate 1.3%, matrine 0.05%, glabridin hydroxypropyl-β-cyclodextrin inclusion compound 0.005%, paeoniflorin 0.1%, tetrahydrocurcumin 0.07%, chamomile extract 0.03%, 1 ,3-butanediol 18%, phenoxyethanol 0.6%, water 79.8%;

[0050] The separation and purification process of the above-mentioned matrine is as follows: take 100g of the medicinal material of matrine, crush it and pass it through a 20-mesh sieve, and use 600mL and 70% ethanol to reflux extract it for 2h and 1.5h respectively; combine the two extracts and filter, and the filtrate Concentrate under reduced pressure to obtain extract, and then separate by neutral alumina column chromatography. Elution with a mixture of methanol with a volume ratio of 2:1, TLC detection, color development with an improved bismuth iodide potassium reagent, combining the eluted fractions of matr...

Embodiment 2

[0059] The botanical antisensitizer stock solution FZ AW-101 of this embodiment is mixed by the following components:

[0060] Dipotassium glycyrrhizinate 1.8%, matrine 0.13%, glabridin hydroxypropyl-β-cyclodextrin inclusion compound 0.005%, paeoniflorin 0.08%, tetrahydrocurcumin 0.10%, chamomile extract 0.05%, 1 ,3-butanediol 25%, phenoxyethanol 1.0%, water 71.8%;

[0061] In the separation and purification process of matrine mentioned above, the undersieve was extracted with 500mL and 70% ethanol under reflux for 1.5h and 2h respectively; The height ratio is 1:7, and the mixed solution of chloroform and methanol volume ratio 1.5:1 is used for elution, and other operations are the same as in Example 1 to obtain matrine with a light color and a purity of 98.5%;

[0062] In the separation and purification process of paeoniflorin, 500mL, 250mL, and 250mL of 70% ethanol were used to reflux and extract for 2h, 1.5h, and 1h respectively; The height ratio in the column was 1:5, an...

Embodiment 3

[0070] The botanical antisensitizer stock solution FZ AW-101 of this embodiment is mixed by the following components:

[0071] Dipotassium glycyrrhizinate 2.0%, matrine 0.15%, glabridin hydroxypropyl-β-cyclodextrin inclusion compound 0.003%, paeoniflorin 0.15%, tetrahydrocurcumin 0.08%, chamomile extract 0.05%, 1 ,3-butanediol 22%, phenoxyethanol 1.0%, water 74.5%;

[0072] In the separation and purification process of matrine above, the undersieve was extracted with 800mL and 70% ethanol under reflux for 1.5h and 1.5h respectively; The height ratio in the mixture is 1:9, and the mixed solution of chloroform and methanol volume ratio 2.2:1 is used for elution, and other operations are the same as in Example 1, and matrine with a light color and a purity of 98.7% is obtained;

[0073] In the separation and purification process of paeoniflorin, 500mL, 300mL, and 250mL of 70% ethanol were used to reflux and extract for 2h, 1h, and 1h respectively; The height ratio in the mixtur...

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Abstract

The invention discloses a vegetable anti-allergic agent stock solution and a preparation method and application thereof. The anti-allergic agent stock solution is compounded by the following components in percentage by weight through the basic theory of traditional Chinese medicine: 1.3-2.0% of dipotassium glycyrrhizinate, 0.05-0.15% of matrine, 0.003-0.005% of glycyrrhizin hydroxypropyl-beta-cyclodextrin inclusion compound, 0.08-0.15% of paeoniflorin, 0.07-0.10% of tetrahydrocurcumin, 0.03-0.05% of chamomile extract, 18.0-25.0% of 1,3-butanediol, 0.6-1.0% of phenoxyethanol and the balance ofwater, and the anti-allergic agent stock solution is added into whitening and anti-allergic skin care products by 2-10% by weight. The components in the anti-allergic agent stock solution are obtainedby purification and refining by a modern extraction and separation technology, the color is light and the taste is light, and the user experience is improved. The dipotassium glycyrrhizinate has anti-inflammatory and anti-allergic effects, and is combined with radix sophorae flavescentis, Chinese herbaceous peony, hydrogenated rhizoma curcumae longae and the chamomile extract to be more effectivein astringing, repairing and nourishing the skin; and in vitro and human body evaluation tests show that the components in the anti-allergic agent stock solution have a synergistic promoting effect,and the anti-allergic and anti-inflammatory effects are good.

Description

technical field [0001] The invention belongs to the field of cosmetics and relates to a botanical antisensitivity agent stock solution, and also relates to a preparation method and application of the antisensitivity agent stock solution. Background technique [0002] At present, the anti-allergic ingredients in cosmetic formulations are mostly chemical synthesis products. Because chemically synthesized anti-allergic raw materials not only have high toxicity and side effects, but also easily cause skin dependence. In addition, at the present stage, the country has stricter and stricter requirements on synthetic anti-allergic raw materials added to cosmetics, which makes the market more and more need natural anti-allergic raw materials with special effects. [0003] However, the current plant-based antisensitizers added in cosmetics have the disadvantages of deep color and heavy odor due to their simple extraction process and extensive methods, and the customer experience is ...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/60A61K8/49A61K8/63A61K8/35A61Q19/00A61K36/28A61P37/08A61P17/00A61P29/00C07D471/22C07H17/04C07H1/08A61K31/704A61K31/4375A61K31/7048A61K31/12A61K31/352
CPCA61K8/35A61K8/4926A61K8/498A61K8/602A61K8/63A61K31/12A61K31/352A61K31/4375A61K31/704A61K31/7048A61K36/28A61K2236/333A61K2236/39A61K2236/51A61K2236/55A61K2800/592A61K2800/782A61Q19/005A61K8/9789A61P17/00A61P29/00A61P37/08C07D471/22C07H1/08C07H17/04A61K2300/00
Inventor 高颖赵富虎董玉玲朱志贤李向阳张凤凤
Owner 甘肃泛植制药有限公司
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