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Application of membranin Annexin A2 of cell Thp-1 in Ac-Gal-1 induced apoptosis

A thp-1, membrane protein technology, applied in the field of life sciences, can solve the problems such as

Active Publication Date: 2019-02-05
WENZHOU MEDICAL UNIV
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Problems solved by technology

Galectins play an important role in inducing apoptosis, but there is no research and application of Angiostrongylus cantonensis Galectin-1 having the function of inducing apoptosis, and the membrane protein receptor that induces apoptosis

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  • Application of membranin Annexin A2 of cell Thp-1 in Ac-Gal-1 induced apoptosis
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  • Application of membranin Annexin A2 of cell Thp-1 in Ac-Gal-1 induced apoptosis

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Embodiment Construction

[0150] In order to further understand the content, characteristics and effects of the present invention, the following examples are given, and detailed descriptions are given below in conjunction with the accompanying drawings. It should be noted that this embodiment is illustrative, not restrictive, and cannot limit the protection scope of the present invention thereby.

[0151] The reagents used in the present invention, unless otherwise specified, are conventional reagents in the art; the methods used in the present invention, unless otherwise specified, are conventional methods in the art.

[0152] Application of Annexin A2, a membrane protein on Thp-1 cells, in the apoptosis induced by Galectin-1 of Angiostrongylus cantonensis.

[0153] Further, the application is the application of Angiostrongylus cantonensis protein Galectin-1 inducing Thp-1 cell apoptosis through cell membrane protein Annexin A2.

[0154] Further, the application is the application of Angiostrongylus ...

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Abstract

The invention relates to application of membranin Annexin A2 of a cell Thp-1 in Angiostrongylus Cantonensis (Ac) protein Galectin-1 induced apoptosis. According to the application of the membranin Annexin A2 of the cell Thp-1 in Ac protein Galectin-1 induced apoptosis, the application provides a theoretical basis for researching applications of a pathogenesis mechanism and control of Ac and treatment of angiostrongyliasis cantonensis and provides a potential acting target, i.e., the Annexin A2 for research and development of treatment drugs; meanwhile, a foundation for research and developmentof angiostrongyliasis cantonensis treatment drugs is laid, and a target is provided for customized treatment of the Ac, so that the application has considerable market prospect and applicability.

Description

technical field [0001] The invention belongs to the technical field of life sciences, in particular to the application of the membrane protein Annexin A2 on Thp-1 cells in the induction of apoptosis by Angiostrongylus Cantonensis (Ac) protein Galectin-1. Background technique [0002] Angiostrongylus Cantonensis is an important pathogen that causes eosinophilic meningitis, which can cause damage to the central nervous system and lead to death in severe cases. Galectins play an important role in inducing apoptosis, but there is no research and application of Angiostrongylus cantonensis Galectin-1 having the function of inducing apoptosis, and the membrane protein receptor that induces apoptosis. [0003] Through searching, the existing research similar to the patent application of the present invention is as follows: [0004] (1) Human Galectins protein has the function of inducing apoptosis. [0005] (2) Galectin-1 of Angiostrongylus cantonensis is an important immunomodula...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/02G01N33/68
CPCG01N33/5044G01N33/6845
Inventor 黄慧聪闫宝龙史晓萌
Owner WENZHOU MEDICAL UNIV
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