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Application of imidazole[4,5-b]pyridine mercapto-acetamide derivative to preparation of human solid tumor resistant medicament

A technology of pyrithione and human solid tumors, which is applied in the field of medicine and can solve problems such as the application of such compounds that have not been found

Active Publication Date: 2019-02-05
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Chinese patent document CN105175414A discloses imidazo[4,5-b]pyridine thiolamide derivatives (general formula I) and its preparation method and application. Regarding the application, only imidazole [4,5-b]pyridine thiol is disclosed The application of amide derivatives in the preparation of prevention of human immunodeficiency virus (HIV) infection and anti-leukemia drugs, while leukemia is a tumor disease completely different from human solid tumors, and the prior art has not found the use of such compounds in other aspects application

Method used

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  • Application of imidazole[4,5-b]pyridine mercapto-acetamide derivative to preparation of human solid tumor resistant medicament
  • Application of imidazole[4,5-b]pyridine mercapto-acetamide derivative to preparation of human solid tumor resistant medicament
  • Application of imidazole[4,5-b]pyridine mercapto-acetamide derivative to preparation of human solid tumor resistant medicament

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Embodiment 1

[0029] Embodiment 1: Antitumor activity test (CCK-8 method)

[0030] Purpose:

[0031] The in vitro cytotoxic activity and strength of the compounds were tested against 4 cells including human large cell lung cancer cell line NCI-H460, human liver cancer cell line Bel-7402, human colon cancer cell line SW620, and human breast cancer cell line MDA-MB-231.

[0032] Experimental Materials:

[0033] 96-well cell culture plates were purchased from Costar;

[0034] RPMI 1640 medium was purchased from Gibco;

[0035] DMEM medium was purchased from Gibco;

[0036] Fetal bovine serum was purchased from Gibco;

[0037] DMSO was purchased from Sigma;

[0038] Eno Gene Cell TM Counting Kit-8 (CCK-8) cell viability detection kit (E1CK-000208-10) was purchased from Nanjing Enjing Biotechnology Co., Ltd.

[0039] laboratory apparatus:

[0040] ChemBase CBS-CJ-1FD ultra-clean bench,

[0041] MCO-15AC carbon dioxide incubator, Japan Sanyo SANYO,

[0042] XD-202 fluorescence inverted ...

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Abstract

The invention relates to an imidazopyridine mercapto-acetamide derivative shown as a general formula I or a medicinal salt thereof, a pharmaceutical composition containing the compound, and application of the pharmaceutical composition to the preparation of a human solid tumor resistant medicament. Human solid tumors include human large cell lung cancer, human liver cancer, human colon tumor and human breast cancer. The general formula I is shown in the description.

Description

technical field [0001] The invention relates to the application of imidazo[4,5-b]pyridine thioethanamide derivatives or pharmaceutically acceptable salts, esters or prodrugs in the preparation of anti-human solid tumor drugs, belonging to the technical field of medicine. Background technique [0002] Malignant tumors are common and frequently-occurring diseases that seriously threaten human health and survival. According to the report of the World Health Organization, tens of millions of patients die from cancer every year in the world, and in recent years, due to the aggravation of environmental pollution and bad living habits, the incidence of tumors, especially malignant tumors, and the number of cancer deaths each year are increasing year by year. rise. Drug therapy plays an important role in the treatment of malignant tumors. Although there are dozens of antitumor drugs commonly used in clinical practice, there are still many problems, such as poor water solubility, s...

Claims

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Application Information

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IPC IPC(8): A61K31/437A61K31/444A61P35/00
CPCA61K31/437A61K31/444A61P35/00A61K2300/00
Inventor 展鹏刘新泳宋宇宁武高禅李潇
Owner SHANDONG UNIV
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