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Method of preparing self-driving gradient-composition hydrogel through supergravity and application of the hydrogel

A composite hydrogel, self-driving technology, applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems of self-driving gradient structure composite hydrogel, complex preparation process, etc., and achieve high application value and practicality. The effect of operability, wide applicability and simple method

Inactive Publication Date: 2019-01-29
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The above-mentioned published literature reports have a certain selectivity for micro-nanoparticles, and the preparation process is relatively complicated. At present, no universal method for micro-nanoparticles has been found to construct composite hydrogels with self-driven gradient structures.

Method used

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  • Method of preparing self-driving gradient-composition hydrogel through supergravity and application of the hydrogel
  • Method of preparing self-driving gradient-composition hydrogel through supergravity and application of the hydrogel
  • Method of preparing self-driving gradient-composition hydrogel through supergravity and application of the hydrogel

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Take 0.001g graphene oxide (GO) and disperse it in 0.5g deionized water, sonicate it for 30min at room temperature to make it fully dispersed; then take 0.113g N-isopropylacrylamide (NIPAM) and dissolve it in 0.5g deionized water, and Add the uniformly dispersed GO mixture into the NIPAM solution, and continue to sonicate for 15 minutes; then add 1.08mg potassium persulfate (KPS) and 0.375mg N,N-methylenebisacrylamide (MBAA) and sonicate until dissolved, and put it in an ice-water bath After standing still for 15 minutes, add 20 μL N,N,N',N'-tetramethylethylenediamine (TEMED), shake evenly, put it in an ice-water bath, and inject it into the mold after 5 minutes. The mold is made of two layers of quartz glass and The PTFE hollow gasket with a thickness of 0.1 mm was centrifuged for 1 min at a centrifugation speed of 4000 r / min; finally, the mold was taken out and left to stand for 12 h to obtain a poly NIPAM / GO gradient composite hydrogel.

[0039]The flow chart of prep...

Embodiment 2

[0041] Take 0.003g of graphene oxide (GO) and disperse it in 0.5g of deionized water, and ultrasonically 30min at room temperature to make it fully dispersed; then take 0.113g of N-isopropylacrylamide (NIPAM) and dissolve it in 0.5g of deionized water, and Add the uniformly dispersed GO mixture into the NIPAM solution, continue to sonicate for 15 minutes, then add 1.08mg potassium persulfate (KPS) and 0.375mg N,N-methylenebisacrylamide (MBAA) sonicate until dissolved, and put it in an ice-water bath After standing still for 15 minutes, add 20 μL N,N,N',N'-tetramethylethylenediamine (TEMED), shake evenly, put it in an ice-water bath, and inject it into the mold after 5 minutes. The mold is made of two layers of quartz glass and The PTFE hollow gasket with a thickness of 0.1 mm was centrifuged for 1 min at a centrifugation speed of 4000 r / min; finally, the mold was taken out and left to stand for 12 h to obtain a poly NIPAM / GO gradient composite hydrogel.

Embodiment 3

[0043] Take 0.005g graphene oxide (GO) and disperse it in 0.5g deionized water, ultrasonic 30min at room temperature to make it fully dispersed; then take 0.113g N-isopropylacrylamide (NIPAM) and dissolve it in 0.5g deionized water, Add the uniformly dispersed GO mixture into the NIPAM solution, continue to sonicate for 15 minutes, then add 1.08mg potassium persulfate (KPS) and 0.375mg N,N-methylenebisacrylamide (MBAA) sonicate until dissolved, and put it in an ice-water bath After standing still for 15 minutes, add 20 μL N,N,N',N'-tetramethylethylenediamine (TEMED), shake evenly, put it in an ice-water bath, and inject it into the mold after 5 minutes. The mold is made of two layers of quartz glass and The PTFE hollow gasket with a thickness of 0.1 mm was centrifuged for 1 min at a centrifugation speed of 4000 r / min; then the mold was taken out and left to stand for 12 h to obtain a poly NIPAM / GO gradient composite hydrogel.

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Abstract

The invention discloses a method of preparing self-driving gradient-composition hydrogel through supergravity and an application of the hydrogel. The method includes: mixing micron-nano particles witha gelatable functional monomer water solution with uniform dispersion, thus obtaining a mixed hydrogel system; centrifuging the mixed hydrogel system, centrifugal rotary speed being 1000-4000 rpm andcentrifugal time being 1-10 min, so that by accurately controlling the rotary speed and centrifugal time of a centrifuge, the micron-nano particles are separated and are gradient-dispersed; performing further gelation to prepare the self-driving gradient-composition hydrogel. The method is simple, low in cost and high in efficiency, has good universality and is green and environment-friendly. Theinvention also discloses the application of the self-driving gradient-composition hydrogel to tissue engineering and intelligent drivers.

Description

technical field [0001] The invention belongs to the technical field of polymer hydrogels, and in particular relates to a method and application for preparing self-driven gradient composite hydrogels by using supergravity. Background technique [0002] Hydrogels can store a large amount of water and have a stable three-dimensional network structure. The good physical and chemical properties and biocompatibility of hydrogels make them have important application prospects in biomedical and industrial applications. [0003] Compared with traditional single-layer hydrogels, bilayer hydrogels exhibit unique anisotropic properties due to their asymmetric structures. Among the many strategies for constructing bilayer hydrogels, adding micro-nanoparticles to the hydrogel system and enriching micro-nanoparticles on one side of the hydrogel through natural sedimentation, phase separation or external force induction are important means. one. [0004] Lee et al. (Eddie Wang, Seung-Wuk ...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08F220/54C08F222/38C08K3/04C08K7/24C08K3/36C08L5/04C08L5/12A61L27/52A61L27/08A61L27/20A61L27/50
CPCA61L27/08A61L27/20A61L27/50A61L27/52A61L2430/02C08F220/54C08F222/38C08J3/075C08J2305/04C08J2305/12C08K3/042C08K3/36C08K7/24C08K2201/011C08F222/385C08L5/04C08L5/12
Inventor 杨晋涛何晓敏钟明强陈枫范萍
Owner ZHEJIANG UNIV OF TECH
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