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A kind of clenbuterol electrochemical sensing electrode and preparation method thereof

A technology of chemical sensing and clenbuterol, which is applied in the field of preparation of electrochemical sensing electrodes, can solve the problems of reduced sensitivity of electrochemical sensors, limitations on the application of molecularly imprinted membranes, and reduced stability and reproducibility, and achieve excellent electronic performance. The effect of transmission ability, lower testing cost and convenient operation

Inactive Publication Date: 2021-01-12
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the preparation process of traditional MIP-ECS, there are disadvantages such as difficult elution of template molecules, difficulty in controlling the thickness of imprinted membranes, and poor reproducibility, which limit the application of molecularly imprinted membranes in electrochemical sensors.
These problems, especially the difficult control of the thickness of the molecularly imprinted membrane, which leads to the decrease of the sensitivity of the electrochemical sensor, and the technical difficulties that the molecularly imprinted membrane is easily detached from the electrode surface during the elution process, resulting in a decrease in stability and reproducibility, limit the application of MIP_ECS. It is of great research significance and market value to find new synthesis methods for molecularly imprinted polymers, new methods for modifying molecularly imprinted membrane electrodes, and methods for combining molecularly imprinted membranes with substrate materials to solve the problems of preparation and application of MIP-ECS.

Method used

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  • A kind of clenbuterol electrochemical sensing electrode and preparation method thereof
  • A kind of clenbuterol electrochemical sensing electrode and preparation method thereof
  • A kind of clenbuterol electrochemical sensing electrode and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0030] The preparation of embodiment 1 Fe-nanoarray

[0031] (1) Use dilute hydrochloric acid, absolute ethanol and deionized disposable electrode for ultrasonic cleaning to remove the oxide layer and surface impurities of the disposable electrode;

[0032] (2) Weigh 1 mmol Fe(NO 3 ) 3 and 3 mmol urea CO(NH 2 ) 2 , put it into a 50 mL beaker, add 30 mL of deionized water and stir until clear, then transfer to a 50 mL polytetrafluoroethylene reactor;

[0033] (3) Put the disposable disposable electrode treated in step (1) into the solution in the reaction kettle in step (2), and react at a temperature of 100 °C for 12 hours to prepare the iron hydroxide nanosheet array precursor body electrode;

[0034] (4) Insert the iron hydroxide nanosheet array precursor electrode obtained in step (3) into the phosphate buffer solution PBS containing dopamine, ammonium persulfate and cobalt nitrate, react at 20 °C for 4 hours, take it out and use Immersed twice in deionized water to p...

Embodiment 2

[0036] The preparation of embodiment 2 Fe-nanoarray

[0037] (1) Use dilute hydrochloric acid, absolute ethanol and deionized disposable electrode for ultrasonic cleaning to remove the oxide layer and surface impurities of the disposable electrode;

[0038] (2) Weigh 2 mmol Fe(NO 3 ) 3 and 6 mmol urea CO(NH 2 ) 2 , put it into a 50 mL beaker, add 30 mL of deionized water and stir until clear, then transfer to a 50 mL polytetrafluoroethylene reactor;

[0039] (3) Put the disposable disposable electrode treated in step (1) into the solution in the reaction kettle in step (2), and react at a temperature of 110 °C for 11 hours to prepare the precursor of iron hydroxide nanosheet array body electrode;

[0040] (4) Insert the iron hydroxide nanosheet array precursor electrode obtained in step (3) into the phosphate buffer solution PBS containing dopamine, ammonium persulfate and cobalt nitrate, react at 30 °C for 5 hours, take it out and use Immersed in deionized water for 3 t...

Embodiment 3

[0042] The preparation of embodiment 3 Fe-nanoarray

[0043] (1) Use dilute hydrochloric acid, absolute ethanol and deionized disposable electrode for ultrasonic cleaning to remove the oxide layer and surface impurities of the disposable electrode;

[0044] (2) Weigh 3 mmol Fe(NO 3 ) 3 and 9 mmol urea CO(NH 2 ) 2 , put it into a 50 mL beaker, add 30 mL of deionized water and stir until clear, then transfer to a 50 mL polytetrafluoroethylene reactor;

[0045] (3) Put the disposable disposable electrode treated in step (1) into the solution in the reaction kettle in step (2), and react at a temperature of 130 °C for 9 hours to prepare the iron hydroxide nanosheet array precursor body electrode;

[0046] (4) Insert the ferric hydroxide nanosheet array precursor electrode obtained in step (3) into the phosphate buffer solution PBS containing dopamine, ammonium persulfate and cobalt nitrate, react at 40 °C for 6 hours, take it out and use Immersed in deionized water for 4 tim...

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Abstract

The invention discloses a preparation method of a clenbuterol electrochemical sensing electrode, and belongs to the technical fields of novel nano function materials and food safety analysis. According to the method, firstly, an iron-hydroxide nano sheet array is prepared on a disposable electrode, a large specific surface area and highly-active hydroxyl functional-groups thereof, hydroxyl functional-groups of poly-dopamine and an in-situ growth method are utilized for successively and directly preparing a poly-dopamine film containing electron mediators and molecularly imprinted polymers withclenbuterol as template molecules on the iron-hydroxide nano sheet array, positions of original template molecules become holes after template molecule elution, that is, the molecularly imprinted polymers of the template molecules are eluted, and thus preparation of the clenbuterol electrochemical sensing electrode is completed.

Description

technical field [0001] The invention relates to a preparation method and application of an electrochemical sensing electrode. It belongs to the field of new nano functional materials and food safety analysis technology. Background technique [0002] Clenbuterol is a class of drugs called beta-agonists, not a specific drug. According to the "Clenbuterol" Special Rectification Program (Food Safety Office [2011] No. 14) stipulated by the Office of the Food Safety Committee of the State Council, there are 16 types of "Clenbuterol", including: ractopamine, clenbuterol, and albuterol , salbutamol sulfate, dopamine hydrochloride, cimaterol, terbutaline sulfate, phenylethanolamine A, bambuterol, zilpaterol hydrochloride, chlorprenaline hydrochloride, mabuterol, sibuterol, bromine Buterol, arformoterol tartrate, formoterol fumarate. Because they can promote protein deposition and fat decomposition in animals, inhibit fat deposition, and can significantly increase carcass lean meat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/26G01N27/30G01N27/327
CPCG01N27/26G01N27/30G01N27/3278
Inventor 刘召壹张勇魏琴
Owner UNIV OF JINAN
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