Novel glucose sensor free from interference of xylose

Abstract

The invention discloses a novel glucose sensor free from interference of xylose. The sensor, based on regulation of formulation, is free from influence of a xylose interference factor on the basis ofhaving the own advantages of dehydrogenase. The sensor comprises a substrate layer, an electrode layer located on the substrate layer, an insulating layer located on the electrode layer, a reagent layer covering the insulating layer, a hydrophilic septal composite layer located between the insulating layer and the reagent layer, and a shielding adhesive tape layer located on the hydrophilic septalcomposite layer, wherein the number of electrodes is reduced for the electrode layer through sharing of a packed cell volume counter electrode and a blood glucose test counter electrode, electrode structure is optimized, and the shielding adhesive tape layer is provided with a rectangular notch which is convenient for blood sample and quality control liquid test. The glucose sensor provided by the invention is optimized in formulation and rational in structure design, has less interference factors and is highly precise in test.

Description

technical field [0001] The invention belongs to the technical field of medical equipment, and relates to a glucose sensor and a testing method in a blood sugar detection equipment, in particular to a novel xylose-free glucose sensor. Background technique [0002] Biosensors such as glucose sensors generally form an electrode system including a working electrode and a counter electrode on an insulating substrate, and add enzymes and electron mediators on it to form a reagent layer; the commonly used electron mediator is potassium ferricyanide and ruthenium compounds. [0003] The enzymes used in common glucose sensors on the market have undergone a process of transformation from glucose oxidase (GOD) to glucose dehydrogenase (GDH). replaced by GDH affected by oxygen interference. [0004] At present, there are roughly three types of GDH: NAD-GDH with nicotinamide adenine dinucleotide (NAD) as a coenzyme, PQQ-GDH with pyrroloquinoline quinone (PQQ) as a coenzyme, and flavin ...

AI Technical Summary

Problems solved by technology

Most of these use FAD-GDH, but it is interfered by xylose levels in the blood

[0005] However, in the case of using ruthenium hexaamine trichloride alone as the electron mediator of FAD-GDH to make a glucose sensor, it is impossible to obtain a current value that depends on the glucose concentration in the blood sample, resulting in the inability to accurately measure the blood glucose level.

Images