Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for extracting saponins component from Yixinshu composition by supercritical fluid extraction method

A supercritical extraction method and saponin technology, which is applied to plant/algae/fungi/moss components, medical preparations containing active ingredients, drug combinations, etc. The extraction rate and purity cannot meet the problems of production and use, so as to achieve the effects of easy preparation, reduced drug dosage and good therapeutic effect

Inactive Publication Date: 2019-01-18
GUIZHOU XINBANG PHARMACEUTICAL CO LTD
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since there are many kinds of active ingredients of medicines that need to be extracted, the active ingredients of Yixinshu preparations obtained through the above-mentioned traditional preparation process are basically crude extracts, and the extraction rate and purity cannot meet the needs of production and use, which will not only cause patients The dosage is relatively large, and it will directly affect the quality and clinical efficacy of the product

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for extracting saponins component from Yixinshu composition by supercritical fluid extraction method
  • Method for extracting saponins component from Yixinshu composition by supercritical fluid extraction method
  • Method for extracting saponins component from Yixinshu composition by supercritical fluid extraction method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 of the present invention: A method for extracting saponins in Yixinshu composition by supercritical extraction method is as follows: Ginseng, Ophiopogon japonicus, Schisandra chinensis, Astragalus membranaceus, Salvia miltiorrhiza, Rhizoma Chuanxiong, and hawthorn are crushed to 1.0 mm, and dried at low temperature. According to the weight of the prescription amount, extract alone or after mixing; use supercritical carbon dioxide as the extraction agent, the entrainer is 80% ethanol, the pressure is 40MPa, the temperature is 50°C, the flow rate of carbon dioxide is controlled at 25L / h, and the extraction is 3h. Obtain the raffinate for the first time; then use 70% ethanol as the entrainer, the pressure is 30MPa, the temperature is 50°C, the flow rate of carbon dioxide is controlled at 30Kg / h, and the raffinate for the first time is extracted for the second time for 3h , to obtain the raffinate for the second time; adopting 95% ethanol as the entrainer again, th...

Embodiment 2

[0035] Example 2 of the present invention: A method for extracting saponins in Yixinshu composition by supercritical extraction method is as follows: Ginseng, Ophiopogon japonicus, Schisandra chinensis, Astragalus membranaceus, Salvia miltiorrhiza, Rhizoma Chuanxiong, and hawthorn are crushed to 0.3 mm, and dried at low temperature. Weigh according to the weight of the prescription amount, extract alone or after mixing; use supercritical carbon dioxide as the extraction agent, the entrainer is acetone, the pressure is 30MPa, the temperature is 40°C, the flow rate of carbon dioxide is controlled at 10L / h, and the extraction is 2h. The primary raffinate; then 60% ethanol is used as an entrainer, the pressure is 20MPa, the temperature is 40°C, the carbon dioxide flow rate is controlled at 10Kg / h, and the first raffinate is extracted for the second time for 2 hours to obtain The raffinate for the second time; 70% ethanol is used as the entrainer again, the pressure is 20MPa, the te...

Embodiment 3

[0036] Example 3 of the present invention: A method for extracting saponins in the Yixinshu composition by supercritical extraction method is as follows: Ginseng, Ophiopogon japonicus, Schisandra chinensis, Astragalus membranaceus, Salvia miltiorrhiza, Rhizoma Chuanxiong, and hawthorn are crushed to 2.0 mm, and dried at low temperature. Weigh and extract according to the weight ratio of the prescription quantity; use supercritical carbon dioxide as the extraction agent, the entrainer is ethyl acetate, the pressure is 50MPa, the temperature is 60°C, the flow rate of carbon dioxide is controlled at 30L / h, and the extraction is 4h. Obtain the raffinate for the first time; then use 80% ethanol as the entrainer, the pressure is 25MPa, the temperature is 60°C, the flow rate of carbon dioxide is controlled at 20Kg / h, and the raffinate for the first time is extracted for the second time for 4 hours , to obtain the second raffinate; then use 85% ethanol as the entrainer, the pressure is 3...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a method for extracting a saponins component from Yixinshu composition by a supercritical fluid extraction method and a product thereof, and specifically relates to pulverizing ginseng, radix Ophiopogonis, fructus Schisandrae Chinensis, radix astragali, radix Salviae Miltiorrhizae, rhizoma Ligustici Chuanxiong and fructus crataegi to 0.3-2.0 mm in prescription amount, drying at low temperature, extracting separately or mixing. The saponins in Yixinshu preparation were extracted with supercritical carbon dioxide as extractant, which provided saponins effective ingredients for the development of new preparation.

Description

technical field [0001] The invention relates to a method for extracting active ingredients in a Yixinshu composition by a supercritical extraction method and a product thereof, belonging to the technical field of preparation of Yixinshu preparations. Background technique [0002] Yixinshu preparation has the functions of replenishing qi and recovering pulse, promoting blood circulation and removing blood stasis, nourishing yin and promoting body fluid. It is used for Qi and Yin deficiency, palpitations, pulse knots, chest tightness, chest pain, and angina pectoris of coronary heart disease. According to literature reports, more than 20 million people die of cardiovascular and cerebrovascular diseases in the world every year, and nearly 400,000 in my country. Traditional Chinese medicine has accumulated rich clinical experience in the diagnosis and treatment of this disease, and traditional Chinese medicine prescriptions have unique advantages in the treatment of cardiovascul...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/8968A61P9/10
CPCA61K36/258A61K36/236A61K36/481A61K36/537A61K36/57A61K36/734A61K36/79A61K36/8968A61K2236/37A61K2236/39A61P9/10A61K2300/00
Inventor 安怀略
Owner GUIZHOU XINBANG PHARMACEUTICAL CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com