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Use of dauricine in preparation of drugs for treatment of mitochondria in alzheimer's disease

A technology for Alzheimer's disease and dauricine, applied in the field of medicine, can solve problems such as lack of drugs, achieve the effects of inhibiting the production of active oxygen, restoring the mitochondrial membrane potential, and reducing the rate of paralysis

Inactive Publication Date: 2019-01-18
GUILIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, there is still a lack of drugs for the treatment of AD, and it is urgent to develop new treatment approaches and drugs to better treat Alzheimer's disease

Method used

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  • Use of dauricine in preparation of drugs for treatment of mitochondria in alzheimer's disease
  • Use of dauricine in preparation of drugs for treatment of mitochondria in alzheimer's disease
  • Use of dauricine in preparation of drugs for treatment of mitochondria in alzheimer's disease

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Embodiment Construction

[0019] In order to better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments and accompanying drawings.

[0020] According to the present invention, the APP (myloid beta (A4) precursor protein) gene is transfected first in neuron cells, which is a conventional technique: that is, APP gene is transfected in SH-SY5Y cells, APPsw cells are constructed, and combined with Cu 2+ Induced neuron cells to construct Alzheimer's disease cell model.

[0021] Effect of Dauricine on Apoptosis

[0022] with different concentrations of Cu 2+ After the APPsw cells were treated, a certain concentration (1 μM) of dauricine was given to detect the cell viability value, and the kit was the cck8 detection kit of Japanese colleagues; 2+ The concentration was 150 μM, dauricine was added after 2 hours of treatment, and it was found that dauricine had the best repairing e...

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Abstract

The invention discloses the application of dauricine in preparing medicine for treating mitochondria of Alzheimer's disease. The dauricine up-regulates mitochondrial membrane potential, down-regulatesthe concentration of reactive oxygen species in cells and up-regulates the concentration of Bcl-2 protein expression level; Dauricine can reduce the paralysis rate of AD model nematodes. The protective effect of dauricine on mitochondrial function could be used to develop new therapeutic drugs for AD. In addition, the cell model of Alzheimer's disease constructed by the invention can be used forthe research of AD.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of dauricine in the preparation of a drug for treating Alzheimer's disease mitochondria. Background technique [0002] Alzheimer's disease (AD), also known as senile dementia, is a degenerative disease of the central nervous system; its onset is insidious, and its course is chronic and progressive. It is the most common type of senile dementia. According to relevant data, the number of patients with Alzheimer's disease (commonly known as senile dementia) in my country has increased exponentially, from only 3 million in 1999 to 9 million in 2016, and it is estimated that the number will reach 36 million in 2050. At present, Alzheimer's disease is mainly treated for several possible pathogenesis, abnormal deposition of Aβ protein, hyperphosphorylation of Tau protein, synaptic dysfunction and neurotransmitter abnormality, and mitochondrial autophagy dysf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4725A61P25/28C12N15/85C12N15/90
CPCA61K31/4725A61P25/28C12N15/85C12N15/90
Inventor 陈薇王凌峰莫靖欣蒲志军李明新
Owner GUILIN MEDICAL UNIVERSITY
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