Phospholipid silymarin vitamin E composition and preparation method and application thereof

A technology of silymarin and vitamins, which is applied in the direction of drug combinations, pharmaceutical formulations, and medical preparations of non-active ingredients, etc., can solve the problems of affecting clinical application and curative effect, poor oral absorption, and low bioavailability, so as to achieve good absorption and low cost. Inexpensive, highly bioavailable effects

Inactive Publication Date: 2019-01-18
江苏天美健大自然生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Silymarin is a kind of thistle plant extract, which contains 4 kinds of flavonoid lignan isomers, which have anti-oxidation, anti-fibrosis and membrane stabilization effects. "Cleansing agent"; its effects include anti-oxidation, controlling inflammatory response, enhancing glutathione, stabilizing cell membrane, immune regulation, liver cell regeneration and improving insulin resistance, etc., thereby reducing hepatic steatosis; but silymarin is insoluble in water and General organic solvent, and poor oral absorption, low bioavailability, thus affecting its clinical application and curative effect
[0003] Chinese patent CN101229209A discloses a preparation method and application of milk thistle oil liposome, which relates to a preparation method and application of a medicine for treating liver diseases. One, 2-6 parts by weight of milk thistle oil, 10 - 25 parts of lecithin, 2-8 parts of cholesterol and 2-8 parts of poloxamer are dissolved in 2-10 parts of mixed organic solvents, and concentrated under reduced pressure in a water bath at 35-45 ° C to 1 part of the original volume / 8-1 / 12; 2. Add 2-4 parts of normal saline with a pH value of 4, and perform ultrasonic vibration for 12-18 minutes at 35-45°C in a water bath; the prepared milk thistle oil liposome Can be used to treat liver diseases; however, it suffers from poor oral absorption and low bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The phospholipid milk thistle vitamin E composition comprises the following raw materials in parts by weight:

[0043] Silymarin, 26 servings;

[0044] Soy lecithin, 53 servings;

[0045] Vitamin E, 8 servings;

[0046] soybean oil, 8 parts;

[0047] beeswax, 5 parts.

[0048] The above components are mixed to produce the product.

Embodiment 2

[0050] The phospholipid milk thistle vitamin E composition comprises the following raw materials in parts by weight:

[0051] Silymarin, 20 servings;

[0052] Soy lecithin, 45 servings;

[0053] Vitamin E, 5 servings;

[0054] soybean oil, 5 parts;

[0055] beeswax, 3 parts;

[0056] Spirulina, 12 parts by weight;

[0057] Sucrose fatty acid ester, 7 parts;

[0058] Sodium Alginate, 2 parts.

[0059] The preparation method of the above-mentioned phospholipid milk thistle vitamin E composition comprises the following steps:

[0060] Step 1, dissolving sucrose fatty acid ester in ethanol solution; the mass fraction of sucrose fatty acid ester is 8%;

[0061] Step 2, ultrasonically dissolving the silymarin in ethyl acetate, wherein the mass ratio of silymarin to ethyl acetate is 3:40; adding the soybean lecithin, vitamin E, soybean oil, and beeswax, and ultrasonically dissolving completely; heating to Add the solution prepared in step 1 dropwise under ultrasonic condition...

Embodiment 3

[0065] The phospholipid milk thistle vitamin E composition comprises the following raw materials in parts by weight:

[0066] Silymarin, 26 servings;

[0067] Soy lecithin, 53 servings;

[0068] Vitamin E, 8 servings;

[0069] soybean oil, 8 parts;

[0070] Beeswax, 5 parts;

[0071] Spirulina, 14 parts by weight;

[0072] Sucrose fatty acid ester, 9 servings;

[0073] Sodium Alginate, 2 parts.

[0074] The preparation method of the above-mentioned phospholipid milk thistle vitamin E composition comprises the following steps:

[0075] Step 1, dissolving sucrose fatty acid ester in ethanol solution; the mass fraction of sucrose fatty acid ester is 10%;

[0076] Step 2, ultrasonically dissolving the silymarin in ethyl acetate, wherein the mass ratio of silymarin to ethyl acetate is 3:40; adding the soybean lecithin, vitamin E, soybean oil, and beeswax, and ultrasonically dissolving completely; heating to Add the solution prepared in step 1 dropwise under ultrasonic condi...

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PUM

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, in particular to a phospholipid silymarin vitamin E composition and a preparation method and application thereof, wherein the phospholipid silymarin vitamin E composition comprises the following raw materials in parts by weight: silymarin, 20-30 parts; Soybean Egg Phosphorus, 45-60 parts; Vitamin E, 5-10 parts; Soybean oil, 5-10 parts; Beeswax, 3-7 parts; At the same time, add 12-16 parts by weight of phycocyan, 7-11 parts by weight of sucrose fatty acid ester, 2-3 parts by weight of sodium alginate; The phospholipidsilymarin vitamin E composition of the invention adopts cheap raw materials and is easy to obtain, so the cost is low; The active ingredient content in the composition is high, the bioavailability ofthe silymarin is high, and the silymarin is well absorbed.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a phospholipid milk thistle vitamin E composition and a preparation method and application thereof. Background technique [0002] Silymarin is a kind of thistle plant extract, which contains 4 kinds of flavonoid lignan isomers, which have anti-oxidation, anti-fibrosis and membrane stabilization effects. "Cleansing agent"; its effects include anti-oxidation, controlling inflammatory response, enhancing glutathione, stabilizing cell membrane, immune regulation, liver cell regeneration and improving insulin resistance, etc., thereby reducing hepatic steatosis; but silymarin is insoluble in water and General organic solvent, and poor oral absorption, low bioavailability, thus affecting its clinical application and curative effect. [0003] Chinese patent CN101229209A discloses a preparation method and application of milk thistle oil liposome, which re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/357A61K47/24A61K47/22A61K47/44A61P1/16
CPCA61K9/19A61K31/357A61K47/22A61K47/24A61K47/44A61P1/16
Inventor 饶安平李玲王荣昌王玉莹甘露汪普林张雯雯
Owner 江苏天美健大自然生物工程有限公司
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