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A microsphere catheter thread plug device for rat mcao model

A technology of microspheres and catheters, which is applied in the field of experimental devices in medical research, can solve problems such as inability to reflect reperfusion blood flow, and achieve the effects of avoiding vasospasm, good repeatability, and easy operation

Inactive Publication Date: 2020-06-19
湖南利华生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the detection method of perfusion first, followed by tail vein injection of non-ionic contrast agent Uvism cannot reflect the ultra-early reperfusion blood flow, and has great limitations in application.

Method used

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  • A microsphere catheter thread plug device for rat mcao model
  • A microsphere catheter thread plug device for rat mcao model
  • A microsphere catheter thread plug device for rat mcao model

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0019] The method of using the microsphere catheter thread plug device of the present embodiment is as follows:

[0020] 1.1 After anesthetizing the rat, keep the body temperature, scrape off the neck hair of the rat with a dermatome, disinfect the neck skin, and cover with a sterile towel. Rats were placed under an operating microscope. Take a longitudinal straight incision in the middle of the neck, from the neck and mandibular reflex at the top, to the sternal angle at the bottom, cut the anterior cervical fascia to expose the right sternocleidomastoid muscle, and separate the sternocleidomastoid muscle from the front of the neck Muscle group, retract the muscle tissue with a thin wire, fully separate and expose the right carotid artery system. The right common carotid artery was carefully separated, and the incision was sutured after cleaning the operative field.

[0021] 1.2 Use ophthalmic scissors to cut a small opening from the bifurcation of the right common carotid ...

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Abstract

The utility model relates to a microsphere catheter wire plug device, which is composed of a support catheter, a microsphere catheter, a tail microsphere pre-loaded with an oil liquid, and a membrane-shaped front microsphere structure. The tail microspheres are connected with the front microspheres through a microsphere conduit. Squeeze the tail microspheres, squeeze a certain volume of oily liquid to the front microspheres through the microsphere catheter, and make it expand, which is used to embolize the middle cerebral artery. The inner diameter of the supporting catheter is larger than that of the microsphere catheter, which can be inserted into the initial segment of the internal carotid artery to serve as vascular support. The front end microsphere of the device of the invention canrealize more thorough and more reliable blocking, At the same time, the infusion of contrast-enhanced material can be delivered to the embolism area at the time of embolization, and the embolization effect can be checked. At the same time, the infusion of other drugs can be delivered to the middle cerebral artery or embolism area.

Description

technical field [0001] The invention relates to an experimental device for medical research, a microsphere catheter thread embolization device for rat middle cerebral artery occlusion (MCAO) model and a drug delivery device for middle cerebral artery or embolism area. Some embodiments of the present invention are applicable to: (1) Embolization of the middle cerebral artery during the MCAO operation in which the microsphere catheter wire is tied, and at the same time, the infusion of contrast-enhancing materials can be delivered to the embolized area to check the embolization effect. (2) The microsphere catheter can deliver the infusion of other drugs to the middle cerebral artery or embolized area. Background technique [0002] Stroke, also known as stroke and cerebrovascular accident, has the characteristics of high morbidity, high mortality and high disability rate, and its clinical manifestations are neurological dysfunction such as hemiplegia and aphasia. It is an acut...

Claims

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Application Information

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IPC IPC(8): A61D7/00
CPCA61D7/00
Inventor 刘劼朱益辉黄明辉
Owner 湖南利华生物科技有限公司
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