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Lactobacillus rhamnosus with effect of relieving colitis and application of lactobacillus rhamnosus

A technology of Lactobacillus rhamnosus and colitis, applied in the field of microbiology, can solve the problems that the efficacy of Lactobacillus rhamnosus colitis has not been reported, etc., to repair colonic mucosal damage, reduce pro-inflammatory factors, and increase the level of short-chain fatty acids Effect

Inactive Publication Date: 2019-01-04
NANCHANG UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, there is no report on the efficacy of Lactobacillus rhamnosus in alleviating colitis

Method used

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  • Lactobacillus rhamnosus with effect of relieving colitis and application of lactobacillus rhamnosus
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  • Lactobacillus rhamnosus with effect of relieving colitis and application of lactobacillus rhamnosus

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Embodiment 1

[0014] Below in conjunction with accompanying drawing and experimental example, test data, the present invention is described in detail:

[0015] Preparation of the colitis model: After the mice adapted to the experimental environment, fasted for 12 hours, inserted a 3.5F catheter into the intestinal tract about 5.5 cm from the anus, and perfused 100 μL of trinitrobenzenesulfonic acid (TNBS) 50% ethanol solution (containing 2 mg 50% ethanol solution of TNBS), and then put the mouse upside down for 60 seconds to prevent the liquid from flowing out, so as to establish the ulcerative colitis model.

[0016] The model mice were randomly divided into 4 groups: (B) colitis model group (IBD), intragastric administration of normal saline; (C) low-dose Lactobacillus rhamnosus CGMCC NO15573 group: intragastric administration of Lactobacillus rhamnosus CGMCC NO15573 (10 8 CFU / mL) normal saline suspension; (D) Lactobacillus rhamnosus CGMCC NO15573 low dose group: intragastric administrat...

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Abstract

The invention provides lactobacillus rhamnosus with effect of relieving colitis and application of the lactobacillus rhamnosus. The strain is Lactobacillus rhamnosus NCU2217, and has been deposited atthe China General Microbiological Culture Collection Center (CGMCC for short) in April 9, 2018 at the address of Microbiology Research Institute of China Science Academy, No. 3, Courtyard 1, Beichenxi Road, Chaoyang Region, Beijing City with the accession number of CGMCC NO15573. By the lactobacillus rhamnosus and foods prepared from the same, the body weight of a mouse suffering from colitis canrecover fast and is increased, effects of inhibiting oxidative stress injury, reducing proinflammatory factors and increasing level of the proinflammatory factors are achieved, the level of short chain fatty acid in colonic fecal is increased remarkably, and meanwhile, injury of colonic mucosa can further be repaired.

Description

technical field [0001] The invention belongs to the field of microorganisms, and in particular relates to a strain of Lactobacillus rhamnosus capable of alleviating colitis and its application. Background technique [0002] Lactobacillus rhamnosus is a probiotic lactic acid bacterium that has been widely studied abroad in recent years, and it widely exists in traditional fermented dairy products and the human gastrointestinal tract. A large amount of data have shown that Lactobacillus rhamnosus has broad development and application prospects in the field of probiotics. Current research results have confirmed that Lactobacillus rhamnosus has the following probiotic functions: (1) antibacterial effect. According to reports, Lactobacillus rhamnosus has inhibitory effects on some pathogenic bacteria in food and intestines, and the antibacterial substances produced by its fermentation have inhibitory effects on Gram-positive, negative bacteria and various pathogenic bacteria; ( ...

Claims

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Application Information

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IPC IPC(8): C12N1/20A23L33/135A61K35/747A61P1/00A61P29/00C12R1/225
CPCA23V2002/00A61K2035/115A23L33/135A61P1/00A61P29/00C12N1/205C12R2001/225A23V2200/32
Inventor 熊涛谢明勇关倩倩黄涛
Owner NANCHANG UNIV
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