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Preparation and application of chitosan and propylene glycol alginate blended microcapsules

A technology of propylene glycol alginate and chitosan, which is applied in the direction of microcapsule preparation, microsphere preparation, microcapsules, etc., can solve the problem of poor water absorption and swelling of pure chitosan products, lack of hydrophilic and water-retaining groups, and difficulty in forming crosslinks Structure and other issues, to achieve good structural stability, good biocompatibility, good effect

Active Publication Date: 2019-01-04
QINGDAO MINGYUE BIOMEDICAL MATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the lack of hydrophilic and water-retaining groups in the molecular structure of chitosan, the water absorption and swelling properties of pure chitosan products are poor.
Propylene glycol alginate is a non-ionic water-soluble polymer. Although it can be processed into microspheres and microcapsules, it is not easy to form a cross-linked structure during processing, so that the resulting pure propylene glycol alginate product will Dissolution, lack of structural stability during application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 3 grams of chitosan was dissolved in 97 grams of 1% (w / w, mass percentage concentration) acetic acid aqueous solution to form a chitosan solution containing 3% (w / w). 3 g of propylene glycol alginate was dissolved in 97 g of water to form a 3% (w / w) propylene glycol alginate solution. In a 500 ml beaker the above chitosan solution and propylene glycol alginate solution were mixed. The mixed solution is directly extruded into a 2% NaOH aqueous solution through a syringe to obtain wet-state blended microcapsules. The wet microcapsules are washed with water and then dried at 80° C. to obtain dry blended microcapsules.

[0034] The chitosan and propylene glycol alginate blended microcapsules in Example 1 had a diameter of about 3000 microns in wet state, and a diameter of about 400 microns after drying. Get 1 gram of dry blended microcapsules, soak in 40 milliliters of normal saline solution (the aqueous solution containing 0.9% sodium chloride), place 30 minutes under 37...

Embodiment 2

[0036] 15 grams of chitosan was dissolved in 485 grams of 1% w / w acetic acid aqueous solution to form a 3% w / w chitosan solution. 15 grams of propylene glycol alginate was dissolved in 485 grams of water to form a 3% w / w propylene glycol alginate solution. In a 200ml beaker, mix 100g, 90g, 75g, 50g, 25g, 10g of chitosan solution with 1g, 10g, 25g, 50g, 75g, 100g of algae The propylene glycol ester solution is mixed, and after fully stirring, the resulting blended solution is extruded into a 4% NaOH aqueous solution under the action of an 8,000-volt pulsed electrostatic field (pulse width of 4 milliseconds, and a frequency of 180 Hz) to obtain wet-state blended microcapsules . The wet microcapsules are washed with water and then dried at 80° C. to obtain dry blended microcapsules. The hygroscopicity of 7 samples was measured respectively according to the method in Example 1, and the obtained results are shown in Table 1 below.

[0037] Table 1

[0038] 3% Propylene...

Embodiment 3

[0042] 2 grams of chitosan was dissolved in 98 grams of 0.5% (w / w, mass percentage concentration) acetic acid aqueous solution to form a chitosan solution containing 2% (w / w). 4 g of propylene glycol alginate was dissolved in 96 g of water to form a 4% (w / w) propylene glycol alginate solution, and 0.5 g of bone morphogenetic protein (BMP-2) was added after the complete dissolution. In a 500 ml beaker the above chitosan solution and propylene glycol alginate solution were mixed. The mixed solution was extruded into a 3% NaOH aqueous solution through a syringe under a high-voltage electrostatic field (voltage: 8kv; pulse width: 3ms; frequency: 100Hz) to obtain wet-state blended microcapsules with an average diameter of 200 μm.

[0043] Select 25 male rats of the same month, inject the drug-loaded microspheres into the abdominal cavity of the rats, and take out five rats from the abdominal cavity after 4 hours, 8 hours, 24 hours, 3 days and 5 days after the injection. The microc...

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Abstract

The invention provides preparation and application of chitosan and propylene glycol alginate blended microcapsules, and relates to the field of microcapsule preparation and application. Chitosan is dissolved by an acetum solution with the mass percent concentration of 0.5-5%, propylene glycol alginate is dissolved by water, then the two solutions are blended, under a high-voltage static field, theblended solution is extruded into a 2-8% NaOH aqueous solution to form wet blended microcapsules, and after washing and drying, the dried blended microcapsules are obtained. The prepared chitosan andpropylene glycol alginate blended microcapsules can be taken as embolism substances for vascular embolism, the embolism substances are injected or conveyed into the target blood vessel through a catheter, so that the blood vessel at the target position is blocked, good expansibility can avoid that the microcapsules move in the blood vessel, the structures of the microcapsules are stable, and embolism can be more stable; the microcapsules can be applied to slow-release medicine and taken as a carrier of the slow-release medicine, the blended microcapsules are combined with the medicine to achieve the slow releasing effect of the medicine, and good slow releasing performance is achieved.

Description

technical field [0001] The invention relates to the field of microcapsule preparation and application, in particular to the preparation and application of chitosan and propylene glycol alginate blended microcapsules. Background technique [0002] Chitin (also known as chitin, chitin, shell protein, crab shellin), is the second largest natural polymer material after cellulose, and its chemical structure is (1,4)-2-acetamido-2 - Deoxy-beta-D-glucan. Chitosan (also known as chitosan) is a polymer amino polysaccharide obtained after deacetylation of chitin, and its molecular structure is (1,4)-2-ammonia-2-deoxy-β-D-glucose polysaccharides. Chitosan can be dissolved in dilute acid aqueous solution and processed into films, fibers and microcapsules. Chitosan has good biocompatibility, biodegradability, hemostasis, and promotion of wound healing. It is used in surgical sutures, medical dressings, artificial skin, hard tissue repair materials, artificial kidney membranes, antibac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02B01J13/04A61K9/52A61K47/36A61K8/73A61Q19/00A61L24/04A61L24/00
CPCA61K8/733A61K8/736A61K9/5036A61L24/001A61L24/043A61Q19/00B01J13/02B01J13/025B01J13/04C08L5/08C08L5/04
Inventor 张德蒙张梦雪邓云龙石少娟秦益民
Owner QINGDAO MINGYUE BIOMEDICAL MATERIALS
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