Proton application system for automatic and rapid detection of boron concentration and operation method thereof

Abstract

The invention belongs to the technical field of treatment, and discloses a proton application system for automatic and rapid detection of boron concentration. The proton application system for the automatic and rapid detection of the boron concentration comprises a low energy linear accelerator system used for generating proton beams and accelerating energy of the proton beams and an automatic boron-containing sample boron concentration rapid detection system which is used for automatic and rapid boron concentration quantitative measurement of batch boron samples and comprises a detection transmission section, a neutron irradiation device, an automatic boron-containing sample inlet device, a prompt gamma detection and analysis device, a beam current gathering device and a detection and control system. The proton application system can not only realize automatic and rapid detection of the boron concentration in the boron-containing samples, but also connect a neutron capture treatment system and / or a radionuclide production system at the same time, the device function is high, and the integration level is high. The invention further provides a boron-containing sample boron concentration rapid detection method. The efficiency of boron concentration detection for a large number of boron-containing samples is effectively improved and the cost of boron concentration detection is greatly reduced.

Description

technical field [0001] The invention relates to the technical field of radiotherapy, in particular to a proton application system for automatically and rapidly detecting boron concentration. Background technique [0002] Boron Neutron Capture Therapy (BNCT) is a bio-targeted binary radiotherapy mode with "drug-machine combination" and better safety. It has the advantages of radiotherapy, chemotherapy, heavy ion therapy and other means in principle Advantages, the most hopeful realization of human good wishes to cure tumors. BNCT treatment first injects non-toxic boron-carrying drugs with pro-tumor tissue into human blood, and after the boron (boron-10) drugs are enriched in tumor tissues, epithermal neutrons are used to irradiate the tumor site in a multi-directional conformal manner. When the protons meet the boron-10 nuclides in cancer cells and undergo a nuclear reaction, the released alpha particles and lithium-7 particles have strong lethality to cells, and the killing...

AI Technical Summary

Problems solved by technology

In such a BNCT center, a large number of boron-containing blood samples need to be quickly quantitatively measured for boron concentration during the treatment process. The existing method of using ICP spectrometer to detect boron concentration in boron-containing blood samples cannot meet the detection requirements.

The main reasons are as follows: 1) One ICP spectrometer can only detect one boron-containing blood sample at the same time, and it takes several minutes; the above-mentioned BNCT center needs to be equipped with multiple ICP spectrometers, and at the same time, it needs to be equipped with multiple people to operate the detection equipment. The cost is huge, and the detection cost is high; 2) The detection process mainly relies on manpower, using manual operation, which is inefficient and error-prone, and this detection method cannot be transformed into an automated and assembly line detection operation

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