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Botulinum toxin for primary disorders of mood and affect using neurotransmitter

A botulinum toxin and neurotransmitter technology, which is applied in neuromuscular system diseases, nervous system diseases, muscular system diseases, etc., can solve problems such as unexplainable and uncertain statistical significance

Inactive Publication Date: 2018-12-21
REVANCE THERAPEUTICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the statistical significance of these results was uncertain, with conflicting treatment groups showing unexplained inverted dose-response curves (Silberstein et al. (2000) Botulinum toxin type A as amigraine preventive treatment. Headache 40(6 ):445-50)

Method used

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  • Botulinum toxin for primary disorders of mood and affect using neurotransmitter
  • Botulinum toxin for primary disorders of mood and affect using neurotransmitter
  • Botulinum toxin for primary disorders of mood and affect using neurotransmitter

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0224] A 78-year-old man with documented sleep disturbance and anxiety was initially diagnosed with blepharospasm. Subjects who administered botulinum toxin by injection recorded improved sleep and reduced anxiety.

Embodiment 2

[0226] A 44-year-old bus driver was diagnosed with hemifacial spasm and reported symptoms of anxiety. Botulinum toxin is administered by injection. Subjects recorded a better ability to cope with work-related stress and to cope with difficult situations with less stress.

Embodiment 3

[0228] Botulinum toxin administered by injection in the treatment of a 72-year-old consultant with a diagnosis of hemifacial spasm who reported sleep disturbance and anxiety. Subjects reported improved sleep and reduced anxiety and agitation.

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Abstract

The invention provides methods for treating primary disorders of mood and affect, including depressive disorders, anxiety, and sleep disorders and CNS disorders comprising the administration of a neurotoxin.

Description

[0001] This application claims the benefit of U.S. Patent Application Serial No. 14 / 464,740, filed August 21, 2014, which claims priority to U.S. Patent Application Serial No. 11 / 447,984, filed June 7, 2006, which claims four priority Rights: U.S. Provisional Application No. 60 / 690,162, filed June 14, 2005; U.S. Provisional Application No. 60 / 693,771, filed June 27, 2005; U.S. Provisional Application No. 60 / 721,060, filed September 28, 2005; US Provisional Application No. 60 / 738,981, filed November 23, 2005, is hereby incorporated by reference in its entirety. field of invention [0002] The present invention relates to the use of neurotoxins in the treatment of primary mood and affective disorders, including depression, anxiety and sleep disorders, as well as other CNS disorders. The present invention relates to neurotransmitter imaging of parts of the brain and central nervous system for the selection of patients for botulinum administration and for the selection of suitable...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/08A61K38/16A61P25/00
CPCA61K38/4893A61K9/0085A61P21/00A61P25/00A61P25/06A61P25/08A61P25/14A61P25/16A61P25/18A61P25/20A61P25/22A61P25/24A61P25/28A61P29/00A61P9/12
Inventor G·鲍罗迪克M·阿夸得罗
Owner REVANCE THERAPEUTICS INC
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