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Chitosan modified salvia miltiorrhiza extract double-phase medicine-carrying nano lipid carrier and preparation method thereof

A nano-lipid carrier and drug-loaded nanotechnology, applied in the field of medicine, can solve the problems of low bioavailability and poor oral absorption, and achieve the effect of simple preparation process, high drug loading, and good drug efficacy

Inactive Publication Date: 2018-12-21
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] There are fewer dosage forms for compounding the water-soluble and fat-soluble components of Danshen, and the fat-soluble components of Danshen have the disadvantages of poor oral absorption and low bioavailability (Hao H, Wang G, Cui N, et al.Pharmacokinetics, absorption and tissue distribution of tanshinone IIA solid dispersion[J].Planta Med, 2006, 72:1311-1317.)
There is no biphasic drug-loaded nanolipid carrier (NLC) of chitosan-modified Danshen extract

Method used

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  • Chitosan modified salvia miltiorrhiza extract double-phase medicine-carrying nano lipid carrier and preparation method thereof
  • Chitosan modified salvia miltiorrhiza extract double-phase medicine-carrying nano lipid carrier and preparation method thereof
  • Chitosan modified salvia miltiorrhiza extract double-phase medicine-carrying nano lipid carrier and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation of the chitosan-modified Danshen extract biphasic drug-loaded nano-lipid carrier comprises the following steps:

[0038] Take 250mg of glyceryl palmitate, 250mg of glyceryl monostearate, 200mg of poloxamer 188, 50mg of soybean lecithin, 60mg of soybean oil, and 20mg of vitamin E. After heating and melting at 75°C, add 5mg of Danshen fat-soluble extract , stir and mix quickly with a glass rod, put it in the refrigerator at -20°C to solidify, then transfer the solidified mixture to an ultrasonic tube with an insulating sleeve, the ultrasonic temperature is 75°C, add 10mL ultrapure water, and select a 400W ultrasonic Power, use an ultrasonic cell pulverizer to sonicate 20 times, each time for 10S, with an interval of 10S; then keep warm at 75°C to absorb the dispersion after ultrasonication, and filter it with a 0.45μm microporous membrane to obtain the nano-lipid carrier of the fat-soluble extract of Salvia miltiorrhiza; Another 35 mg of Danshen water-solu...

Embodiment 2

[0040] The preparation of the chitosan-modified Danshen extract biphasic drug-loaded nano-lipid carrier comprises the following steps:

[0041] Take 150mg of glyceryl palmitate, 350mg of glyceryl monostearate, 300mg of poloxamer 188, 100mg of soybean oil, 50mg of soybean lecithin, and 20mg of vitamin E. After heating and melting at 75°C, add the fat-soluble extract of Salvia miltiorrhiza 8mg, stir and mix quickly with a glass rod, put it in the refrigerator at -20°C to solidify, then transfer the solidified mixture to an ultrasonic tube with an insulated sleeve, the ultrasonic temperature is 75°C, add 10ml ultrapure water, and use ultrasonic cell The pulverizer ultrasonicated 20 times under the condition of ultrasonic power 600W, each ultrasonic 6S, interval 6S; after that, keep warm to absorb the dispersion liquid after ultrasonic, filter with 0.45 μm microporous membrane to obtain the nano-lipid carrier of the fat-soluble extract of Salvia miltiorrhiza; Dissolve 56mg of Dans...

Embodiment 3

[0043] The preparation of the chitosan-modified Danshen extract biphasic drug-loaded nano-lipid carrier comprises the following steps:

[0044] Take glyceryl palmitate 350mg, glyceryl monostearate 150mg, poloxamer 188 250mg, soybean oil 80mg, soybean lecithin 50mg, 2,6-di-tert-butylated hydroxytoluene 20mg, heat at 75°C After melting, add 5 mg of the fat-soluble extract of Salvia miltiorrhiza, stir and mix quickly with a glass rod, put it in the refrigerator at -20°C to solidify, and then transfer the solidified mixture to an ultrasonic tube with a thermal insulation sleeve. The ultrasonic temperature is 75°C. Add 10mL concentration to 1.5mg·mL -1 For chitosan acetic acid aqueous solution with pH=5, use an ultrasonic cell pulverizer to sonicate 30 times at an ultrasonic power of 400W, each time for 6S, with an interval of 6S; then keep warm to absorb the dispersion after ultrasonication, and filter it with a 0.45μm microporous membrane , to obtain chitosan-modified salvia mil...

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Abstract

The invention relates to a chitosan modified salvia miltiorrhiza extract double-phase medicine-carrying nano lipid carrier and a preparation method thereof, and aims at realizing efficient utilizationof salvia miltiorrhiza. According to the technical scheme, the chitosan modified salvia miltiorrhiza extract double-phase medicine-carrying nano lipid carrier is prepared from the following components in percentage by weight: 0.001-5% of a salvia miltiorrhiza liposoluble extract, 0.001-10% of a salvia miltiorrhiza water-soluble extract, 0.01-15% of solid lipid material, 0.001-5% of liquid lipid material, 0.01-10% of a surfactant, 0.001-2% of a chitosan compound, 0.001-0.5% of an antioxidant, and the balance of a water solution. The preparation comprises two methods. The chitosan modified salvia miltiorrhiza extract double-phase medicine-carrying nano lipid carrier is scientific in formula, simple to prepare, reliable in quality, high in stability, and suitable for industrial massive production; the prepared nano lipid carrier is high in medicine carrying capacity and can be stably stored for a long term; the safety is high; and the pharmacologic effects of salvia miltiorrhiza liposoluble extract and the water-soluble extract can be effectively exerted.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a chitosan-modified salvia miltiorrhiza extract biphasic drug-loaded nano lipid carrier and a preparation method thereof. Background technique [0002] Salvia miltiorrhiza is the dry root and rhizome of Salvia miltiorrhiza Bge., which is bitter and slightly cold. GUIXIN, pericardium, Liver Channel. It has the effects of promoting blood circulation and removing blood stasis, cooling blood and heart, nourishing blood and calming the nerves. Traditional Chinese medicine is mainly used for rheumatic arthralgia, lumps in the abdomen, swelling and pain of sores, irregular menstruation, and postpartum stasis and pain. [0003] Modern pharmaceutical research shows that the effective chemical components of Danshen mainly include fat-soluble components and water-soluble components, and the fat-soluble components are mainly tanshinone-type diterpenoids, including tanshinone Ⅱ A, tanshinone Ⅱ B, cry...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/127A61K47/36A61P9/10
CPCA61K9/127A61K36/537A61K47/36A61P9/10
Inventor 郑甲信王艳芝刘宏民常乐吴惠珍孙灿灿王显马格格王喜平
Owner ZHENGZHOU UNIV
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