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Application of saffron pigment composition in preparation of medicines for treating Parkinson's disease

A technology for saffron pigment and Parkinson's disease, which is applied in the application field of saffron pigment composition in the preparation of medicines for treating Parkinson's disease, can solve the problems of fluctuating symptoms and abnormal movement, cannot prevent the development of the disease, and has poor curative effect of symptoms, etc. The effect of improving various symptoms of Parkinson's disease, improving movement disorders, and increasing quantity

Active Publication Date: 2018-12-21
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current drug treatment cannot prevent the development of the disease, let alone cure it.
In particular, patients who take medication for a long time will develop tolerance to various western medicines, and are prone to complications such as symptom fluctuations and abnormal movements, so that western medicines are less effective in improving PD symptoms in the later stage of treatment.

Method used

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  • Application of saffron pigment composition in preparation of medicines for treating Parkinson's disease
  • Application of saffron pigment composition in preparation of medicines for treating Parkinson's disease
  • Application of saffron pigment composition in preparation of medicines for treating Parkinson's disease

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preparation example Construction

[0043] Further, the preparation method of this type of saffron pigment composition comprises:

[0044] Step S1: using solvent extraction method to extract the fruit of Gardenia jasmine to obtain the total extract of Gardenia jasmine;

[0045] Wherein, the solvent extraction method includes any one or more of decoction method, heating reflux extraction method, ultrasonic vibration extraction method, percolation method and immersion method. The extraction solvent that solvent extraction method adopts is the alcoholic solution of 55~65Vol%, optional, is the ethanol or the methanol solution that is selected as 55~65Vol%; The volume fraction of alcohol in the alcoholic solution is 55~65Vol%, or is 58~ 62Vol%, or 60Vol%.

[0046] When the heating reflux extraction method is used for extraction, the ratio of solid to liquid (that is, the mass ratio of raw material to extraction solvent) is 1:3-5, or 1:4. A more preferred way is: heating and refluxing extraction with 4 times the amo...

Embodiment 1

[0055] The preparation method of the gardenia saffron pigment active composition is consistent with the preparation method in the Chinese patent CN105935363 previously applied by the inventor, specifically as follows:

[0056] Take 40.0 kg of dried and mature fruits of Gardenia jasminoides, after being crushed properly, heat and reflux extract with 4 times the amount of 60% ethanol for 3 times, each time for 2 hours. The extracts were combined, and the solvent was evaporated under reduced pressure to obtain 6.2 kg of the total gardenia extract; the extract was dissolved in an appropriate amount of water, centrifuged, and subjected to macroporous resin open column chromatography (20.0 × 90 cm), followed by 4 times the volume of the column bed Water, 30%, 50%, 70%, and 95% ethanol were used for gradient elution, and each part of the eluate was collected, and the solvent was recovered under reduced pressure, respectively, to obtain about 4.5kg of water elution and 30% ethanol elut...

Embodiment 2

[0058] Saffron pigment active composition GJ-4 improves the symptoms of MPTP-induced subacute PD mice

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Abstract

The invention provides application of a saffron pigment composition in the preparation of medicines for treating Parkinson's disease, and relates to the field of medicines. Found in study, the saffronpigment composition extracted from plants has the advantages that the mobility dysfunction of a mouse can be obviously relieved, the number of TH (tyrosine hydroxylase) positive neurons in substantianigra is increased, the content of DA (dopamine) in the brain striatum of the mouse is increased, and the certain dose reliance is realized; the obvious treatment function is realized on the Parkinson's disease model mouse caused by MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), and the certain anti-Parkinson's disease activity is realized.

Description

technical field [0001] The invention relates to the field of medicines, in particular to the application of a saffron pigment composition in the preparation of medicines for treating Parkinson's disease. Background technique [0002] Parkinson's disease (Parkinson's, PD) is the second largest neurodegenerative disease after Alzheimer's disease. Epidemiology shows that the incidence of PD increases with age, and the incidence of people over 65 years old is about 1%, seriously affecting the health and quality of life of the elderly. The main pathological features of PD are the progressive degeneration and death of dopaminergic neurons in the midbrain and the formation of Lewy bodies in the cells, which eventually lead to the functional decline of the nigrostriatal dopaminergic system, resulting in movement disorders. Its main clinical manifestations are resting tremor, muscle stiffness, and bradykinesia. Various factors are involved in the pathogenesis of PD. [0003] The in...

Claims

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Application Information

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IPC IPC(8): A61K31/7024A61P25/16A23L33/125
CPCA23L33/125A23V2002/00A61K31/7024A61P25/16A23V2200/30
Inventor 姚新生张丹于洋鲍秀琦李婷盛婵娟臧彩霞王越
Owner JINAN UNIVERSITY
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