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Chitosan-based gauze dressing loaded with metal ions and preparation method thereof

A technology for loading metals and metal ions, which is used in medical science, bandages, absorbent pads, etc. It can solve the problems of too fast gel formation, inability to save and use, uncontrollable pH value, etc. high rate effect

Active Publication Date: 2018-12-18
WENZHOU MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its disadvantage is that the formed gel is soft and brittle, and cannot be directly made into a dressing. If it is applied on the wound surface, it must be in-situ gel-forming method, which cannot be stored for use, and because the gel-forming speed is too fast, it is difficult to mix the NaOH solution evenly. PH can't be controlled

Method used

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  • Chitosan-based gauze dressing loaded with metal ions and preparation method thereof
  • Chitosan-based gauze dressing loaded with metal ions and preparation method thereof
  • Chitosan-based gauze dressing loaded with metal ions and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] This example provides a preparation load Ag + and Ca 2+ A method for chitosan-based gauze dressing, comprising the steps of:

[0035] Step 1) Weigh 0.25g of chitosan powder and dissolve it in 50ml of 0.1% acetic acid solution to prepare a chitosan solution with a concentration of 0.5%, and place it in an ultrasonic machine for 6 hours;

[0036] Step 2) Prepare AgNO with a concentration of 0.1mol / L 3 , CaSO 4 Solution, keep away from light;

[0037] Step 3) take 50ulAg + and 50ulCa 2+ Solution, mixed evenly with 900ul chitosan solution, made to contain Ag + and Ca 2+ chitosan-metal ion solution, namely Ag + with Ca 2+ The loading concentration is 0.005mol / L;

[0038] Step 4) place the glass slide on the table top, place a polytetrafluoroethylene plate with a hollow in the middle on it, place a pre-cut gauze in the hollow, and evenly drop the solution prepared in step 3) on the gauze; Overlay a glass slide and secure the device with clips;

[0039] Step 5) Fre...

Embodiment 2

[0041] This example provides a preparation load Zn 2+ Chitosan-based gauze dressing method, specific

[0042] Step 1) Weighing 0.25g of chitosan powder and dissolving it in 0.1% acetic acid solution to prepare a chitosan solution with a concentration of 0.5%, and placing it in an ultrasonic machine for ultrasonication for 6 hours;

[0043] Step 2) preparation concentration is the Zn(NO of 0.1mol / L 3 ) 2 Solution, keep away from light;

[0044] Step 3) Take 100ul Zn 2+ The solution is mixed evenly with 900ul chitosan solution to make it containing Zn 2+ Chitosan-metal ion solution, at this time Zn 2+ The loading concentration is 0.01mol / L;

[0045] Step 4) place the glass slide on the table top, place a polytetrafluoroethylene plate with a hollow in the middle on it, place a pre-cut gauze in the hollow, and evenly drop the solution prepared in step 3) on the gauze; Overlay a glass slide and secure the device with clips;

[0046] Step 5) Freeze the samples obtained in st...

Embodiment 3

[0048] This example provides a preparation load Cu 2+ chitosan-based gauze dressing,

[0049] Step 1) Weighing 0.25g of chitosan powder and dissolving it in 0.1% acetic acid solution to prepare a chitosan solution with a concentration of 0.5%, and placing it in an ultrasonic machine for ultrasonication for 6 hours;

[0050] Step 2) prepare CuSO with a concentration of 0.1mol / L 4 Solution, keep away from light;

[0051] Step 3) take 100ul Cu 2+ The solution was mixed evenly with 900ul chitosan solution to make it containing Cu 2+ Chitosan-metal ion solution, at this time Cu 2+ The loading concentration is 0.01mol / L;

[0052] Step 4) place the glass slide on the table top, place a polytetrafluoroethylene plate with a hollow in the middle on it, place a pre-cut gauze in the hollow, and evenly drop the solution prepared in step 3) on the gauze;

[0053] Overlay a glass slide and secure the device with clips;

[0054] Step 5) Freeze the samples obtained in step 4) at 4°C, -2...

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Abstract

The invention aims at providing a chitosan-based gauze dressing loaded with metal ions and a preparation method thereof. One metal ion or various metal ions can be added according to the requirement,and the gauze dressing can be directly applied to a wound surfaceand can also be used after being laminated layer by layer. The concentration of the loaded metal ions can be adjusted by changing the concentration of a prepared metal ion solution.

Description

technical field [0001] The invention relates to a chitosan-based gauze dressing loaded with multiple metal ions and a preparation method thereof, which can be used as a dressing for acute wounds or infected wounds. Background technique [0002] Metal ions are essential trace elements for the human body, and their research and application in wounds are increasing day by day. Many studies have shown that Ag + , Ca 2+ , Cu 2+ , Zn 2+ , Mg 2+ , Fe 3+ Plasma all contribute to the repair of infected wounds. However, metal ions are generally more toxic to organisms, so chitosan is used to cross-link metal ions to form a gel to achieve sustained release, thereby reducing toxicity and promoting wound healing. Chitosan (CS) has been widely used in biomedical applications due to its non-toxicity, biodegradability, biocompatibility, and bioabsorption properties. There is supramolecular complexation and cross-linking between natural CS chains and various metal ions. It is only n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/18A61L15/42A61L15/44
CPCA61L15/18A61L15/28A61L15/42A61L15/44A61L2300/102A61L2300/412C08L5/08
Inventor 吴疆何华成肖健周亚娇张宏宇李校堃
Owner WENZHOU MEDICAL UNIV
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