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A chitosan-based gauze dressing loaded with metal ions and preparation method thereof

A technology of loading metals and metal ions, applied in bandages, absorbent pads, medical science and other directions, can solve the problems of too fast gel formation, inability to save and use, uncontrollable PH value, etc., to achieve high utilization rate, easy availability of materials, Simple to use effects

Active Publication Date: 2021-07-20
WENZHOU MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its disadvantage is that the formed gel is soft and brittle, and cannot be directly made into a dressing. If it is applied on the wound surface, it must be in-situ gel-forming method, which cannot be stored for use, and because the gel-forming speed is too fast, it is difficult to mix the NaOH solution evenly. PH can't be controlled

Method used

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  • A chitosan-based gauze dressing loaded with metal ions and preparation method thereof
  • A chitosan-based gauze dressing loaded with metal ions and preparation method thereof
  • A chitosan-based gauze dressing loaded with metal ions and preparation method thereof

Examples

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Effect test

Embodiment 1

[0034] This example provides a preparation load Ag + and Ca 2+ A method for chitosan-based gauze dressing, comprising the steps of:

[0035] Step 1) Weigh 0.25g of chitosan powder and dissolve it in 50ml of 0.1% acetic acid solution to prepare a chitosan solution with a concentration of 0.5%, and place it in an ultrasonic machine for 6 hours;

[0036] Step 2) Prepare AgNO with a concentration of 0.1mol / L 3 , CaSO 4 Solution, keep away from light;

[0037] Step 3) Take 50ulAg + and 50ulCa 2+ Solution, mixed evenly with 900ul chitosan solution, made to contain Ag + and Ca 2+ chitosan-metal ion solution, namely Ag + with Ca 2+ The loading concentration is 0.005mol / L;

[0038] Step 4) Place the glass slide on the table, place a hollowed-out polytetrafluoroethylene plate on it, place the pre-cut gauze in the hollowed out place, and evenly drop the solution prepared in step 3) on the gauze; Overlay a glass slide and secure the device with clips;

[0039] Step 5) Freeze t...

Embodiment 2

[0041] This example provides a preparation load Zn 2+ Chitosan-based gauze dressing method, specific

[0042] Step 1) Weigh 0.25g of chitosan powder and dissolve it in 0.1% acetic acid solution to prepare a chitosan solution with a concentration of 0.5%, and place it in an ultrasonic machine for 6 hours;

[0043] Step 2) Prepare Zn(NO 3 ) 2 Solution, keep away from light;

[0044] Step 3) Take 100ul Zn 2+ The solution is mixed evenly with 900ul chitosan solution to make it containing Zn 2+ Chitosan-metal ion solution, at this time Zn 2+ The loading concentration is 0.01mol / L;

[0045] Step 4) Place the glass slide on the table, place a hollowed-out polytetrafluoroethylene plate on it, place the pre-cut gauze in the hollowed out place, and evenly drop the solution prepared in step 3) on the gauze; Overlay a glass slide and secure the device with clips;

[0046] Step 5) Freeze the samples obtained in step 4) at 4°C, -20°C, and -80°C for 8 hours, and finally store them at...

Embodiment 3

[0048] This example provides a preparation load Cu 2+ chitosan-based gauze dressing,

[0049] Step 1) Weigh 0.25g of chitosan powder and dissolve it in 0.1% acetic acid solution to prepare a chitosan solution with a concentration of 0.5%, and place it in an ultrasonic machine for 6 hours;

[0050] Step 2) Prepare CuSO with a concentration of 0.1mol / L 4 Solution, keep away from light;

[0051] Step 3) Take 100ul Cu 2+ The solution was mixed evenly with 900ul chitosan solution to make it containing Cu 2+ Chitosan-metal ion solution, at this time Cu 2+ The loading concentration is 0.01mol / L;

[0052] Step 4) Place the glass slide on the table, place a hollowed-out polytetrafluoroethylene plate on it, place the pre-cut gauze in the hollowed out place, and evenly drop the solution prepared in step 3) on the gauze;

[0053] Overlay a glass slide and secure the device with clips;

[0054] Step 5) Freeze the samples obtained in step 4) at 4°C, -20°C, and -80°C for 8 hours, and ...

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Abstract

The object of the present invention is to provide a chitosan-based gauze dressing loaded with metal ions. The metal ions loaded by the gauze dressing can be added with one or more types as required, and can be directly applied to the wound surface or applied after layering. The loaded metal ion concentration can be adjusted by changing the prepared metal ion solution concentration.

Description

technical field [0001] The invention relates to a chitosan-based gauze dressing loaded with multiple metal ions and a preparation method thereof, which can be used as a dressing for acute wounds or infected wounds. Background technique [0002] Metal ions are essential trace elements for the human body, and their research and application in wounds are increasing day by day. Many studies have shown that Ag + , Ca 2+ , Cu 2+ , Zn 2+ , Mg 2+ , Fe 3+ Plasma all contribute to the repair of infected wounds. However, metal ions are generally more toxic to organisms, so chitosan is used to cross-link metal ions to form a gel to achieve sustained release, thereby reducing toxicity and promoting wound healing. Chitosan (CS) has been widely used in biomedical applications due to its non-toxicity, biodegradability, biocompatibility, and bioabsorption properties. There is supramolecular complexation and cross-linking between natural CS chains and various metal ions. It is only n...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/18A61L15/42A61L15/44
CPCA61L15/18A61L15/28A61L15/42A61L15/44A61L2300/102A61L2300/412C08L5/08
Inventor 吴疆何华成肖健周亚娇张宏宇李校堃
Owner WENZHOU MEDICAL UNIV
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