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Hyaluronic acid as well as preparation method and application thereof

A technology of hyaluronic acid and other aspects, applied in the field of cosmetics, can solve the problems that hyaluronic acid is difficult to be absorbed by the human body, and the moisturizing effect cannot be lasting.

Active Publication Date: 2018-12-14
SHANDONG TIANSHENG BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the high molecular weight also makes it difficult for hyaluronic acid to be absorbed by the body, and the moisturizing effect cannot last after the application surface is in contact with water

Method used

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  • Hyaluronic acid as well as preparation method and application thereof
  • Hyaluronic acid as well as preparation method and application thereof
  • Hyaluronic acid as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1 Preliminary Screening

[0042] In order to develop hyaluronic acid products with better performance, the inventors first prepared HA with different PD and molecular weight ranges.

[0043] Preparation of HA

[0044] Hyaluronic acid of the present invention is obtained by fermenting and purifying Streptococcus zooepidemicus (Sterptococcus zooepidemicus, purchased from ATCC, catalog number is HA-116ATCC39920), and the specific method is as follows:

[0045] culture medium

[0046] Slant medium (g / L): heart brain infusion powder (BHI) 36, glucose 12, yeast powder 12, agar powder 24, pH 7.2.

[0047] Seed medium (g / L): glucose 40, yeast powder 20, magnesium sulfate heptahydrate 2.0, manganese sulfate tetrahydrate 0.1, potassium dihydrogen phosphate 2.0, calcium carbonate 20, pH 7.0.

[0048] Fermentation medium (g / L): yeast powder 20, disodium hydrogen phosphate 6.2, potassium sulfate 1.3, glucose 140, magnesium sulfate heptahydrate 2.0, pH 7.0.

[0049] C...

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Abstract

The invention relates to hyaluronic acid as well as a preparation method and application thereof. The hyaluronic acid has weight average molecular weight of 5kDa-3000kDa, number-average molecular weight of 5kDa-3000kDa and viscosity-average molecular weight of 5kDa-3000kDa; in addition, the hyaluronic acid has a polydispersity coefficient of 7 to 15. The invention also relates to the preparation method and application of a product.

Description

technical field [0001] The present invention relates to the field of cosmetics, in particular, to a hyaluronic acid, a preparation method thereof and use in the preparation of cosmetics. Background technique [0002] Hyaluronan (HA), also known as uronic acid, hyaluronic acid, and glass sugar carbon-based acid, is a linear chain composed of alternating D-glucuronic acid and N-acetyl-D-glucosamine. Linear macromolecular polysaccharides. Hyaluronic acid is present in the connective tissues of vertebrates, such as hyaline cartilage, synovial joint fluid, and skin tissues (dermis and epidermis), and is involved in many physiological processes such as adhesion, development, cell motility, cancer, angiogenesis, and wound healing (Laurent T.C. and Fraser J.R.E., 1992, FASEB J. 6:2397-2404; and Toole B.P., 1991, Proteoglycans and hyaluronan in morphogenesis and differentiation., Cell Biology of the Extracellular Matrix, pp. 305-341, Hay E.D. eds., Plenum , New York). [0003] The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61Q19/08A61Q19/00C12P19/26C12R1/46
CPCA61K8/735A61Q19/00A61Q19/08C12P19/26
Inventor 李榕榕江俊杰于淼
Owner SHANDONG TIANSHENG BIO TECH CO LTD
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