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Method for preparing orthopaedic implant calcium phosphate coating

A calcium phosphate and orthopedic technology, applied in the field of medical biomaterials, can solve the problems of poor universality of electrochemical calcium phosphate coatings, and achieve strong promotion, improved efficiency, and good electrochemical coating effects

Inactive Publication Date: 2018-12-07
四川维思达医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problem of poor universality of electrochemical calcium phosphate coatings in the prior art, and provide a method for preparing calcium phosphate coatings for orthopedic implants with higher versatility

Method used

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  • Method for preparing orthopaedic implant calcium phosphate coating
  • Method for preparing orthopaedic implant calcium phosphate coating
  • Method for preparing orthopaedic implant calcium phosphate coating

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Determining an electrolyte that satisfies optimum electrolyte conditions in a calcium phosphate electrochemical coating comprises the following steps;

[0086] (a) Calcium nitrate 2mM, ammonium dihydrogen phosphate 4mM; calcium nitrate 4mM, ammonium dihydrogen phosphate 8mM; calcium nitrate 8mM, ammonium dihydrogen phosphate 16mM; calcium nitrate 10mM, ammonium dihydrogen phosphate 20mM; calcium nitrate 15mM, phosphoric acid Ammonium dihydrogen 30mM; calcium nitrate 20mM, ammonium dihydrogen phosphate 40mM; a series of mixed solutions of calcium nitrate 25mM and ammonium dihydrogen phosphate 50mM;

[0087] (b) Titrate each group of mixed solutions prepared in step a with NaOH solution with a concentration of 0.1mM until the solution begins to appear turbidity visible to the naked eye, and the turbidity does not disappear after shaking for 30 seconds. Set this point as the titration End point, and record the volume of the NaOH solution that each group of mixed solutions is...

Embodiment 2

[0098] On the basis of embodiment 1, carry out following steps:

[0099] (a) Calcium nitrate 2mM, ammonium dihydrogen phosphate 1.2mM; calcium nitrate 4mM, ammonium dihydrogen phosphate 2.4mM; calcium nitrate 6mM, ammonium dihydrogen phosphate 3.6mM; calcium nitrate 8mM, ammonium dihydrogen phosphate 4.8mM; Calcium 10mM, ammonium dihydrogen phosphate 6mM; calcium nitrate 15mM, ammonium dihydrogen phosphate 9mM; series of mixed solutions of calcium nitrate 20mM, ammonium dihydrogen phosphate 12mM;

[0100] (b) Titrate each group of mixed solutions prepared in step a with NaOH solution with a concentration of 0.1mM until the solution begins to appear turbidity visible to the naked eye, and the turbidity does not disappear after shaking for 30 seconds. Set this point as the titration End point, and record the volume added dropwise of each group of mixed solutions;

[0101] (c) measure the pH value of each group of mixed solutions at the end of titration, and calculate the concen...

Embodiment 3

[0111] On the basis of above-mentioned embodiment, carry out following steps:

[0112] (a) Calcium nitrate 2mM, potassium dihydrogen phosphate 1.2mM; calcium nitrate 4mM, potassium dihydrogen phosphate 2.4mM; calcium nitrate 6mM, potassium dihydrogen phosphate 3.6mM; calcium nitrate 8mM, potassium dihydrogen phosphate 4.8mM; nitric acid Calcium 10mM, potassium dihydrogen phosphate 6mM; calcium nitrate 15mM, potassium dihydrogen phosphate 9mM; series of mixed solutions of calcium nitrate 20mM, potassium dihydrogen phosphate 12mM;

[0113] (b) Titrate each group of mixed solutions prepared in step a with NaOH solution with a concentration of 0.1mM until the solution begins to appear turbidity visible to the naked eye, and the turbidity does not disappear after shaking for 30 seconds. Set this point as the titration End point, and record the volume added dropwise of each group of mixed solutions;

[0114] (c) measure the pH value of each group of mixed solutions at the end of ti...

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Abstract

The invention discloses a method for preparing an orthopaedic implant calcium phosphate coating and belongs to the technical field of medical biomaterials. The method solves the problem of poor generality of an electrochemically prepared calcium phosphate coating in the prior art. The method has high universality. The method comprises: carrying out linear potential sweep on an electrolyte to obtain a linear sweep voltammetry curve, and analyzing the linear sweep voltammetry curve to determine the optimal potential interval of the electrode working in the electrochemical coating of the calciumphosphate so that the electrochemical coating effect of calcium phosphate is further improved. The method tests orthopaedic implants prepared from different materials to determine the corresponding optimal potential interval so that the efficiency of preparing the calcium phosphate coating of the orthopaedic implant and effects of the calcium phosphate coating are greatly improved.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterials, and in particular relates to a method for preparing a calcium phosphate coating for orthopedic implants. Background technique [0002] Many bone diseases such as osteoarthritis and femoral head necrosis are difficult to be cured by drug treatment. Orthopedics widely uses various metal implants to replace and repair these diseased parts. The main metal materials currently used include titanium and its alloys, cobalt alloys, stainless steel, and tantalum. However, it is still difficult for these metal implants to form a high-strength and durable bond with the bone tissue of the patient's implant site as soon as possible to achieve long-term mechanical stability. . Through the study of human bone tissue, it is found that about 70% of the bone tissue is calcium phosphate bone mineral, and the artificially synthesized calcium phosphate ceramics also have good compatibility and affinity w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D9/08C25D21/12G01N27/416
CPCC25D9/08C25D21/12G01N27/4166G01N27/4167
Inventor 段可翁杰汪建新冯波鲁晓波葛建华张喜海周宗国
Owner 四川维思达医疗器械有限公司
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