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A method for evaluating clinical prognosis of glioma using immune co-stimulatory molecules

A technology for glioma and prognosis, applied in the direction of biochemical equipment and methods, microbial measurement/testing, etc., can solve the problems of no reported research on the role of SLAMF8

Active Publication Date: 2021-10-26
THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, to date, no reports have investigated the role of SLAMF8 in cancer

Method used

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  • A method for evaluating clinical prognosis of glioma using immune co-stimulatory molecules
  • A method for evaluating clinical prognosis of glioma using immune co-stimulatory molecules
  • A method for evaluating clinical prognosis of glioma using immune co-stimulatory molecules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Example 1 Application research of SLAMF8 in the prognosis evaluation of human glioma

[0063] method:

[0064] Patient's samples: The present invention involves RNA sequencing results and detailed clinical information data of 946 glioma patients, of which 310 are from the China Glioma Genome Atlas (CGGA), and 636 are from the American Tumor Genome Atlas (TCGA) ( https: / / tcga-data.nci.nih.gov / tcga / tcgaDownload.jsp). Overall survival (OS) was defined as the time from diagnosis to death or the end of final follow-up.

[0065] Bioinformatics analysis: Glioma stromal score, immune score and glioma purity were calculated using R language to evaluate the proportion of non-tumor cell components in the tumor. The R package to calculate microenvironmental cell subpopulations was used to calculate the absolute enrichment of eight types of immune cells and two types of stromal cells. Pearson correlation analysis was used to screen the corresponding genes for functional analysis....

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Abstract

The invention discloses the application of SLAMF8 in preparing preparations of tumor tissue markers or serum markers for evaluating the prognosis of human glioma, and as a marker for evaluating the prognosis of human glioma. The present invention also provides a method for evaluating the clinical prognosis of glioma by using immune co-stimulatory molecules. The present invention finds through research that SLAMF8 is highly expressed in the malignant phenotype of glioma and glioblastoma, and is closely related to the poor prognosis of glioma, and the high expression of SLAMF8 is an important sign of the poor prognosis of glioma. Moreover, high expression of SLAMF8 is associated with chemotherapy resistance. The present invention suggests that SLAMF8 mainly affects the glioma microenvironment through monocytes and dendritic cells, and is closely related to immune response. SLAMF8 can affect glioma immune function, inhibit glioma immune response and promote inflammatory response. In conclusion, SLAMF8 can be used as an important clinical prognostic marker for glioma.

Description

technical field [0001] The present invention relates to a method for evaluating the clinical prognosis of glioma by using immune co-stimulatory molecules, and relates to the application of SLAMF8 in the preparation of tumor tissue markers or serum markers for the evaluation of human glioma prognosis, and the use of SLAMF8 as a human neuroglioma marker. The application of the markers for glioma prognosis evaluation belongs to the technical field of biological detection. Background technique [0002] Glioma is the most common primary tumor of the central nervous system, with a high degree of malignancy, rapid progression, and easy recurrence. The current main treatment method is a comprehensive treatment of surgical resection combined with postoperative radiotherapy and chemotherapy. Despite advances in treatment options, the prognosis for patients with the most malignant form of glioblastoma (GBM) remains poor. Recently, immunotherapy, including chimeric antigen receptor (C...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/118C12Q2600/158
Inventor 邹存义吴安华程文
Owner THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV
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