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A crisaborole sustained-release film having good absorption effects and a preparing method thereof

A technology of cleaborol and sustained-release film, applied in the field of biomedical materials, can solve the problems of not being able to be retained for a long time, easy to be wiped, etc., to achieve the effect of enhancing drug penetration ability, treating fungal infection, and strong penetration ability

Inactive Publication Date: 2018-12-07
苏州尚宜佳生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the crisborole preparations are ointments, which do not involve sustained release, need fixed-point administration, and are easy to be wiped off, so they cannot be kept for a long time

Method used

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  • A crisaborole sustained-release film having good absorption effects and a preparing method thereof
  • A crisaborole sustained-release film having good absorption effects and a preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A, the first layer of sustained-release film preparation: with crisborole 20%, glycerin 25%, microcrystalline cellulose 25%, absorption enhancer 7% (wherein propylene glycol 60%, polysorbate 10%, menthol 10% , grass fruit oil 10% and clove oil 10%), carrageenan 8%, polyvinylpyrrolidone 15% mix fully, melt, extrude film-forming agent with extruder;

[0028] B, the preparation of the second layer of delayed-release film: with crisborole 20%, propylene alcohol 25%, sorbitol 25%, absorption accelerator 7% (propylene glycol 60%, polysorbate 10%, menthol 10%, Straw fruit oil 10% and clove oil 10%), guar gum 8%, polycarbophil 15% mix fully, add appropriate amount of water to dissolve, stir evenly, apply it evenly on the above-mentioned slow-release film, dry in a dryer Dry until there is no obvious moisture, and the drying temperature is 60°C;

[0029] C. Cut and get.

Embodiment 2

[0031] A, the first layer of sustained-release film preparation: with crisborole 25%, polyethylene glycol 23%, modified starch 22%, absorption accelerator 8% (propylene glycol 60%, polysorbate 10%, menthol 10%) , grass fruit oil 10% and clove oil 10%), sodium carboxymethyl cellulose 7%, chitosan 15% mix fully, melt, extrude film-forming agent with extruder;

[0032] B, the second layer of delayed-release film preparation: with crisborole 25%, triacetin 23%, dextrin 22%, absorption enhancer 8% (propylene glycol 60%, polysorbate 10%, menthol 10%) , grass fruit oil 10% and clove oil 10%), sodium carboxymethyl cellulose 7%, polyvinyl alcohol 15% mix well, add appropriate amount of water to dissolve, stir well, apply it evenly on the above-mentioned slow-release film, bake Dry in a dryer until there is no obvious moisture, and the drying temperature is 60°C;

[0033] C. Cut and get.

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PUM

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Abstract

A crisaborole sustained-release film having good absorption effects and a preparing method thereof are disclosed. The film is prepared from an active component, a plasticizer, a filler, an absorptionpromoter, a suspending aid and an adhesive. The film can overcome a problem that medicine use frequency is over-high and can provide longer skin residence time and a decreased number of times of administration. A plurality of film forming auxiliary materials, which supplement each other and which are integral, are adopted to prepare the film, the plasticizer and the filler enhance film forming performance, the absorption promoter enhances medicine infiltration capacity, the suspending aid ensures dispersibility of raw materials in a liquid state, and the adhesive enhances the degree of adhesion between the film and skin.

Description

technical field [0001] The invention relates to a crisborole slow-release film with good absorption effect and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] Crisaborole, an inhibitor of phosphodiesterase 4 (PDE4), which results in increased intracellular levels of cyclic adenosine monophosphate (cAMP), is used in the treatment of fungal infections, more specifically Onychomycosis and / or fungal skin infections. The drug was approved for marketing by the U.S. Food and Drug Administration (FDA) in December 2016. It was developed by Anacor Pharmaceuticals and is responsible for marketing in the United States. The trade name is Crisaborole and its chemical name is 5-(4-cyanophenoxy )-1,3-dihydro-1-hydroxy-2,1-benzoxaborole, the English name is 4-((1-hydroxy-1,3-dihydrobenzo[c][1, 2] oxaborol-5-yl)oxy)benzonitrile, the chemical structural formula is as shown in formula (I): [0003] [0004] The characteristic of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/69A61K47/38A61K47/44A61K47/36A61K47/26A61K47/10A61P31/10A61P17/00
CPCA61K9/7007A61K31/69A61K47/10A61K47/26A61K47/36A61K47/38A61K47/44A61P17/00A61P31/10
Inventor 付任重李建民马义成肖海英
Owner 苏州尚宜佳生物科技有限公司
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