The synthetic method of 2-methyl-1-phenyl-1-propanol

Abstract

The invention discloses a synthesis method of 2-methyl-1-phenyl-1-propanol, which successively includes: 1) under protection of inert gas, adding higher fatty acid or higher fatty acid salt to an organic solvent and adding sodium or granular sodium; 2) adding a mixed solution of halogenated benzene and an organic solvent to perform a reaction at 20-40 DEG C; 3) adding a mixed solution of isobutyraldehyde and an organic solvent to the reaction liquid, and performing a reaction at -20 to 10 DEG C; 4) adding an acid solution or a weak-acid salt water solution to the reaction liquid to perform hydrolysis; 5) performing post-treatment to the reaction liquid to obtain the 2-methyl-1-phenyl-1-propanol. The method is high in raw material utilization rate and avoids usage of expensive catalyst, canreduce emission of waste gas, liquid and solid, reduces production cost, is high in product purity and yield, and has excellent industrial application value.

Description

technical field [0001] The present invention relates to the preparation method of organic compound 2-methyl-1-phenyl-1-propanol. Background technique [0002] 2-Methyl-1-phenyl-1-propanol is an important fine chemical intermediate, mainly used in photoinitiators, pharmaceutical intermediates, material intermediates, etc. [0003] At present, there are mainly four kinds of synthetic techniques about 2-methyl-1-phenyl-1-propanol: [0004] 1. Patent EP 718265 etc. proposed isobutyrophenone reduction method. In this method, isobutyrophenone is used as raw material, and noble metal is used to catalyze the reduction under hydrogen atmosphere. The reaction raw materials of this method are difficult to obtain, the use cost of the catalyst is high, and the high-pressure hydrogen operation requires high equipment. [0005] 2. Grignard reagent synthesis method. According to the difference of Grignard reagents, literature (Organic Chemistry, 2015,35,12,2545-2551) proposes the reacti...

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Problems solved by technology

The catalyst of this method is difficult to prepare, the required reaction temperature is very low, it is difficult to apply industrially, and the yield is only 85%.

In this method, if the -78°C is adjusted to -20~10°C, the by-products will increase (such as biphenyl, terphenyl), and the reaction selectivity will be greatly reduced.

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