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Nano-silver bactericidal and hemostatic composition

A technology of nano-silver and composition, applied in the field of biomedicine, can solve the problems of inability to rapidly stop bleeding and relieve pain, uneven distribution of metal materials, easy adhesion to clothing, etc., to promote wound healing, simple preparation method, and easy large-scale production effect

Active Publication Date: 2018-11-30
沈平凡
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many bactericidal, hemostatic, and wound healing materials developed on the market, and with the continuous improvement of demand, new medical functional hemostatic, sterilizing, and wound healing materials have also appeared, because their formulations and production processes are different. , their functions and application ranges are not the same, but they will have some different problems, for example, some are only used for shallow wound treatment, some have poor hemostatic effect, and cannot stop bleeding and relieve pain quickly after changing the dressing. Cause fear of changing dressings; some are easy to stick to dust and clothes; some are only limited to bactericidal function, that is, there are only bactericides and auxiliary materials in the formula, but no other effects; some stop bleeding and sterilize and promote Wound healing materials have poor biocompatibility; and some nano-silver or other heavy metal medical materials, due to uneven distribution of metal materials, cause local heavy metal residues and cause harm to the human body

Method used

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Examples

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Effect test

preparation example Construction

[0079] The third aspect of the present invention provides the preparation method of the nano-silver bactericidal and hemostatic composition, comprising the following steps:

[0080] (1) Add modified hyaluronic acid and ethacridine lactic acid into the reactor in parts by weight, then add water as a solvent, heat to 55°C-75°C to dissolve, stir evenly, and obtain liquid A;

[0081] (2) Processing liquid A in step (1) to obtain substance B;

[0082] (3) Add carboxymethyl chitosan grafted sodium polyacrylate and auxiliary agents to the substance B in step (2) in parts by weight, heat to 60° C. to 80° C., and stir evenly to obtain substance C;

[0083] (4) cooling and filtering the substance C in step (3) to obtain solid D;

[0084] (5) Sterilize the substance D in the step (4) to obtain a nano-silver bactericidal and hemostatic composition.

[0085] In one embodiment, the specific step of post-treatment described in step (2) is: add 0.5mL N-hydroxysuccinimide (0.06mol / L) / 1-( 3-...

Embodiment 1

[0096] Embodiment 1 of the present invention provides a nano-silver bactericidal and hemostatic composition, the preparation raw materials of the nano-silver bactericidal and hemostatic composition are calculated in parts by weight, and include the following components:

[0097] 30 parts of modified hyaluronic acid;

[0098] 3 parts of ethacridine lactate;

[0099] Carboxymethyl chitosan grafted sodium polyacrylate 5 parts;

[0100] Wherein, the modified hyaluronic acid includes organic components and inorganic components; the inorganic components include nano-silver and / or calcium ions;

[0101] The preparation method of described modified hyaluronic acid is:

[0102] (1) Under a nitrogen atmosphere, weigh 0.01mol of hyaluronic acid, 0.25mol of maleic anhydride, 0.3mol of 2,4-hexadienedioic acid and 0.26mol of 1,2,3,4-diepoxybutane for reaction Add 4.5mL of N,N-dimethylformamide and 0.001mol of tetrabutylammonium bromide to the bottle, heat in an oil bath at 90°C for 18h; ob...

Embodiment 2

[0126] Embodiment 2 of the present invention provides a nano-silver bactericidal and hemostatic composition, the preparation raw materials of the nano-silver bactericidal and hemostatic composition are calculated by weight, and include the following components:

[0127] 50 parts of modified hyaluronic acid;

[0128] 5 parts of ethacridine lactate;

[0129] 8 parts of carboxymethyl chitosan grafted sodium polyacrylate;

[0130] Wherein, the modified hyaluronic acid includes organic components and inorganic components; the inorganic components include nano-silver and / or calcium ions;

[0131] The preparation method of the modified hyaluronic acid is the same as in Example 1;

[0132] The ethacridine lactate CAS: 1837-57-6;

[0133] The preparation method of described carboxymethyl chitosan graft sodium polyacrylate is with embodiment 1;

[0134] The bactericidal and hemostatic combination also includes 3 to 8 parts of auxiliary agents, and the auxiliary agents include povido...

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PUM

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Abstract

The invention relates to the technical field of biological medicine, in more particular to a nano-silver bactericidal and hemostatic composition and a preparation method thereof. Preparation raw materials of the nano-silver bactericidal and hemostatic composition at least comprise the following components of, by weight, 10-50 parts of modified hyaluronic acid, 0.5-5 parts of ethacridine lactate and 2-8 parts of carboxymethyl chitosan grafted sodium polyacrylate, wherein the modified hyaluronic acid comprises an organic component and an inorganic component; and the inorganic component comprisesnano-silver and / or calcium ions.

Description

technical field [0001] The invention relates to the technical field of biomedicine, more specifically, the invention relates to a nano-silver bactericidal and hemostatic composition and a preparation method thereof. Background technique [0002] Bleeding is one of the common emergency symptoms that occurs with many conditions. Excessive blood loss can cause shock and endanger the patient's life. Massive blood loss can reduce the patient's ability to tolerate surgery and affect postoperative recovery. At the same time, bleeding can seriously affect the surgical field of vision, disturb the tissue level, hinder the technical operation, disrupt the operation steps, distract the energy of the operator, and seriously endanger the life of the patient. Whether the bleeding can be stopped quickly and effectively is a key factor in whether the treatment is effective. In addition, in this process, sterilization and rapid wound healing have a great impact on skin repair and life. Wi...

Claims

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Application Information

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IPC IPC(8): A61K33/38A61K47/36A61K47/59A61P31/04A61P7/04A61P17/02A61L15/46A61L15/28A61L15/18A61L15/42A61L15/24A61L15/26A61K31/473A61K31/728A61K33/14A61K31/79
CPCA61K31/473A61K31/728A61K31/79A61K33/14A61K33/38A61K47/36A61L15/18A61L15/24A61L15/26A61L15/28A61L15/42A61L15/46A61L2300/102A61L2300/104A61L2300/106A61L2300/206A61L2300/216A61L2300/404A61L2300/45A61L2400/04A61L2400/12A61K47/593A61P7/04A61P17/02A61P31/04A61K2300/00C08L5/08C08L33/02C08L39/06C08L67/00
Inventor 沈平凡
Owner 沈平凡
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