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Qualitative detection method for wind-heat cold particles

A wind-heat-cold and qualitative detection technology, which is applied in the direction of measuring devices, preparation of test samples, and material analysis by observing the influence of chemical indicators, so as to ensure the quality of drugs, good fluidity, increase product yield and The effect of production efficiency

Inactive Publication Date: 2018-11-27
KANGMEI BAONING (SICHUAN) PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, this variety can only be tested according to the characteristics of this standard and the content under the general rules of granules in the fourth part of the "Chinese Pharmacopoeia" 2015 edition

Method used

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  • Qualitative detection method for wind-heat cold particles

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preparation example Construction

[0035] As a preferred embodiment, the preparation method of the Fengremao Granules comprises:

[0036] In the step of preparing materials, 3.0kg of Fengremao granule extract powder, 5.66kg of sucrose and 1.51kg of dextrin were weighed respectively; Firstly, extraction is carried out, and the extract is concentrated to obtain Fengreganmao granule extract powder;

[0037] Premixing step: mixing sucrose and dextrin together to obtain a premix;

[0038] Adhesive preparation steps: preparing Fengreganmao granule extract powder into extract liquid;

[0039] Spray granulation step: the premixed material is sucked into a fluidized bed granulation dryer through a vacuum feeding pipeline; the extract is used as a binder for spray granulation to obtain Fengreganmao granules.

[0040] As a preferred embodiment, in the step of preparing materials, the preparation step of Fengremao granule extract powder: take Radix Radix Isatidis, Forsythia, Peppermint, Schizonepeta ear, mulberry leaves,...

Embodiment 1

[0049] A qualitative detection method for Fengreganmao granules, comprising:

[0050] 1) Take 1g of Fengreganmao granules, add 10ml of ethanol, heat to boiling, filter after cooling to obtain the filtrate; test the filtrate according to any one of the following two methods:

[0051] Method 1: Take 1ml of the filtrate, add 3 drops of 1% ninhydrin ethanol solution, heat it on a water bath, and it will appear blue-purple or purple-red;

[0052] Method 2: Use a capillary to take 1ml of the filtrate, point it on the filter paper, dry it and place it under a UV lamp with a wavelength of 254nm for observation, and it will show yellow-green fluorescence;

[0053] 2) Take 10g of Fengreganmao granules, add 20ml of petroleum ether at 30-60°C, seal it tightly, treat it with ultrasound for 15 minutes, filter, discard the petroleum ether liquid, evaporate the residue to dry petroleum ether, add 20ml of methanol, seal it tightly, and ultrasonicate Treat for 20 minutes, filter, evaporate the...

Embodiment 2

[0056] A qualitative detection method for Fengreganmao granules, comprising:

[0057] 1) Take 1g of Fengreganmao granules, add 10ml of ethanol, heat to boiling, filter after cooling to obtain the filtrate; test the filtrate according to any one of the following two methods:

[0058] Method 1: Take 1ml of the filtrate, add 3 drops of 1% ninhydrin ethanol solution, heat it on a water bath, and it will appear blue-purple or purple-red;

[0059] Method 2: Use a capillary to take 1ml of the filtrate, point it on the filter paper, dry it and place it under a UV lamp with a wavelength of 254nm for observation, and it will show yellow-green fluorescence;

[0060] 2) Take 10g of Fengreganmao granules, add 20ml of petroleum ether at 30-60°C, seal it tightly, treat it with ultrasound for 15 minutes, filter, discard the petroleum ether liquid, evaporate the residue to dry petroleum ether, add 20ml of methanol, seal it tightly, and ultrasonicate Treat for 20 minutes, filter, evaporate the...

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Abstract

The invention discloses a qualitative detection method for wind-heating cold particles. The method comprises the steps of 1) taking the wind-hot cold particles, adding ethanol, heating to boiling, filtering after cooling, and obtaining a filtrate; performing a ninhydrin chromogenic reaction or a fluorescence reaction on the filtrate; 2) taking the wind-hot cold granules to prepare a test solution,taking forsythia suspensa vahl control medicinal materials to prepare a control medicinal material solution, and testing according to a thin layer chromatography method; 3) taking the wind-heat coldgranules as the test solution; taking the mint medicinal material to make the reference medicinal solution; testing according to thin layer chromatography; 4) taking the wind and heat granules as thetest solution; taking the burdock medicinal materials to prepare the reference medicinal solution; testing according to thin layer chromatography. The method can accurately determine the authenticityof the variety. Further, the method can avoid the one-sidedness of determining the quality of the drug by merely measuring a single component.

Description

technical field [0001] The invention relates to a qualitative detection method of Fengreganmao granules. Background technique [0002] Fengreganmao granule is a compound preparation of traditional Chinese medicine commonly used in clinical practice. It is composed of isatis root, forsythia, mint, nepeta panicle, mulberry leaf, reed root, burdock seed, chrysanthemum, bitter almond, mulberry branch, and Liushenqu. Detoxification, suitable for lung and sore throat. For cold body fever, nasal congestion, headache, cough, phlegm. [0003] The statutory standard of Fengreganmao Granules is the drug standard issued by the Ministry of Health, that is, the first volume of the Ministry of Health drug standard for traditional Chinese medicine preparations (WS3-0044-089). Since it was promulgated, only its prescription, preparation method, and properties have been stipulated, and it has been tested according to the general rules of granules, and there are no other quality control item...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/78G01N21/64G01N30/90G01N1/28G01N1/40G01N30/06
CPCG01N1/28G01N1/40G01N21/64G01N21/78G01N30/06G01N30/90G01N2021/786
Inventor 许冬瑾迟慧春冯志伟赵宏荣
Owner KANGMEI BAONING (SICHUAN) PHARMACEUTICAL CO LTD
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