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Paclitaxel-carrying magnetic fluorescent alginate microsphere system and preparation method thereof

A technology of alginic acid and paclitaxel, applied in the field of nanomaterials, can solve the problem that there is no research or report on the magnetic fluorescent alginic acid microsphere system, and achieve the effects of mild experimental conditions and simple operation.

Inactive Publication Date: 2018-11-27
JINLING INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no research or report on the magnetic fluorescent alginic acid microsphere system loaded with paclitaxel

Method used

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  • Paclitaxel-carrying magnetic fluorescent alginate microsphere system and preparation method thereof
  • Paclitaxel-carrying magnetic fluorescent alginate microsphere system and preparation method thereof
  • Paclitaxel-carrying magnetic fluorescent alginate microsphere system and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0038] A preparation method of a magnetic fluorescent alginic acid microsphere system loaded with paclitaxel, comprising the following steps:

[0039] Add 1.3g ferric chloride to 72.8g (ie 70ml) 1,2-propanediol (PG), then add 0.8g urea (Urea) and 0.4g surfactant sodium dodecylbenzenesulfonate (SDBS), the The product was reacted in a muffle furnace at 210 °C for 5 h, the final product was alternately washed with distilled water and absolute ethanol, and finally dried in vacuum at 40 °C to prepare porous Fe 3 o 4 nanospheres.

[0040] 50mg Fe 3 o 4 Nano microspheres, 80g (ie 80ml) H 2 O. 1.82g (i.e. 2ml) of ammonia water to make a mixed solution, put the mixed solution in a three-necked flask for ultrasonic dispersion for 20min, then add 0.5ml of 3-aminopropyltrimethoxysilane and stir at room temperature (25°C) for 7h, the product was used Alternately washed with distilled water and absolute ethanol, and dried under vacuum at 40°C, Fe can be prepared 3 o 4 -NH 2 Nanopart...

Embodiment 2

[0044] A preparation method of a magnetic fluorescent alginic acid microsphere system loaded with paclitaxel, comprising the following steps:

[0045] Add 1.35g of ferric chloride to 74.88g (ie 72ml) of 1,2-propylene glycol (PG), then add 0.9g of urea (Urea) and 0.5g of surfactant sodium dodecylbenzenesulfonate (SDBS), the The product was reacted in a muffle furnace at 220 °C for 6 h, the final product was alternately washed with distilled water and absolute ethanol, and finally dried in vacuum at 50 °C to prepare porous Fe 3 o 4 nanospheres.

[0046] 60mg Fe 3 o 4 Nano microspheres, 90g (ie 90ml) H 2 O. 2.73g (that is, 3ml) ammonia water to make a mixed solution, put the mixed solution in a three-necked flask for ultrasonic dispersion for 30min, then add 1ml 3-aminopropyltrimethoxysilane and stir at room temperature (25°C) for 8h, and distill the product with distilled water Alternately washed with absolute ethanol and dried in vacuum at 50°C to obtain Fe 3 o 4 -NH 2 ...

Embodiment 3

[0050] A preparation method of a magnetic fluorescent alginic acid microsphere system loaded with paclitaxel, comprising the following steps:

[0051] Add 1.4g of ferric chloride to 76.96g (i.e. 74ml) of 1,2-propanediol (PG), then add 1g of urea (Urea) and 0.6g of surfactant sodium dodecylbenzenesulfonate (SDBS), and the product After reacting in a muffle furnace at 230 °C for 7 h, the final product was alternately washed with distilled water and absolute ethanol, and finally dried in vacuum at 60 °C to prepare porous Fe 3 o 4 nanospheres.

[0052] 70mg Fe 3 o 4 Nano microspheres, 100g (i.e. 100ml) H 2 0. 3.64g (i.e. 4ml) ammonia water was made into a mixed solution, the mixed solution was placed in a three-necked flask for ultrasonic dispersion for 40min, then 1.5ml of 3-aminopropyltrimethoxysilane was added and stirred at room temperature (25°C) for 9h, and the product was used Alternately washed with distilled water and absolute ethanol, and vacuum dried at 60°C, Fe ca...

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Abstract

The invention discloses a paclitaxel-carrying magnetic fluorescent alginate microsphere system and a preparation method thereof. The preparation method includes the steps of preparing magnetic Fe3O4 nano particles by means of a hydrothermal process, and subjecting the particles to amination modification by means of (3-aminopropyl)trimethoxysilane; subjecting the modified particles to carboxylationmodification with SA (sodium alginate) to obtain Fe3O4 / SA magnetic microspheres; enabling the magnetic particles and GQDS (graphene quantum dots) / PTX (paclitaxel) to combine by the aid of chemical bond reaction under the activating action of carbodiimide and N-hydroxysuccinimide so as to obtain magnetic fluorescent alginate drug-carrying microspheres Fe3O4@SA / (PTX-GQDS). The preparation method ofthe system herein is simple to perform and has mild reaction conditions, and the system has high drug-carrying rate and is expectedly widely applicable to the field of biomedicine.

Description

technical field [0001] The invention relates to the field of nanomaterials and biotechnology, in particular to a paclitaxel-loaded magnetic fluorescent alginic acid microsphere system and a preparation method thereof. Background technique [0002] Breast cancer is one of the most common malignant tumors in women. In my country, breast cancer accounts for 7% to 10% of all kinds of malignant tumors in the whole body, second only to cervical cancer. The incidence rate is about 18.7 per 100,000 people. The trend is obvious. Although great progress has been made in the early diagnosis and treatment of breast cancer in my country, 80% of breast cancer patients are still in the middle and advanced stages when they are discovered. Although most of the tumors can be removed by surgery, most of them cannot be cured, and the tumor will eventually recur And metastases, the treatment effect is poor. Therefore, paying attention to breast cancer and women's health has increasingly become t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/52A61K47/61A61K31/337A61K9/16A61K49/00A61P35/00
CPCA61K9/1611A61K9/1652A61K31/337A61K49/0019A61K49/005A61K49/0054A61K49/0091A61P35/00
Inventor 张小娟郝凌云周智鹏顾月皓曹昱璟余彤杨亚婷
Owner JINLING INST OF TECH
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