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Preparation method and production device preventing citric acid coagulation

A production device and technology of citric acid, applied in the field of preparation method and production device to prevent citric acid from coagulating, can solve problems such as easy coagulation, achieve the effects of guaranteeing purity, improving anti-coagulation effect, and ensuring pressure safety

Active Publication Date: 2018-11-23
湖南新绿方药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved in the present invention is to aim at the easy coagulation in the existing citric acid preparation process, especially the poor anti-coagulation effect in the refining process and in the case of anti-emergency, to provide a kind of mild condition, simple operation and high yield High-efficiency, good refining effect, and can effectively prevent the refining process of citric acid coagulation

Method used

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  • Preparation method and production device preventing citric acid coagulation
  • Preparation method and production device preventing citric acid coagulation
  • Preparation method and production device preventing citric acid coagulation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1 prevents the preparation method of citric acid coagulation

[0040] S1. Dissolution: Put 10kg of food-grade anhydrous citric acid crude product into the concentration tank, add 3L of purified water, vacuumize, and continuously feed 0.1MPa steam, heat the feed liquid to 80°C, and stir for 30min;

[0041] S2. Decolorization: add 0.1% activated carbon to the solution obtained in S1, vacuumize, slowly introduce 0.1MPa steam, stir at a constant temperature of 60° C. for 1 hour, and filter to obtain a fine filtrate;

[0042] S3. Concentration and crystallization: depressurize the fine filtrate obtained in S2 to -0.07MPa at 50°C, stir at a speed of 33r / min, concentrate for 4h until the specific gravity of the material reaches 1.34g / ml, cool to 20°C, and crystallize 8h to get citric acid wet granules;

[0043] S4. Separation and purification: the wet citric acid granules obtained in S3 were dehydrated, and dried in a vibrating fluidized bed at a temperature of 55°...

Embodiment 2

[0045] Embodiment 2 prevents the preparation method of citric acid coagulation

[0046] S1. Dissolution: Put 10kg of food-grade anhydrous citric acid crude product into the concentration tank, add 4L of purified water, vacuumize, and continuously feed 0.2MPa steam, heat the feed liquid to 90°C, and stir for 45min;

[0047] S2. Decolorization: add 0.4% activated carbon to the solution obtained in S1, vacuumize, slowly introduce 0.2MPa steam, stir at a constant temperature of 90° C. for 1 hour, and filter to obtain a fine filtrate;

[0048] S3. Concentration and crystallization: depressurize the fine filtrate obtained in S2 to -0.08MPa at 60°C, stir at a speed of 33r / min, concentrate for 8h until the specific gravity of the material reaches 1.40g / ml, cool to 28°C, and crystallize 8h to get citric acid wet granules;

[0049] S4. Separation and purification: the wet citric acid granules obtained in S3 were dehydrated, and dried in a vibrating fluidized bed at a temperature of 55°...

Embodiment 3

[0051] Embodiment 3 prevents the preparation method of citric acid coagulation

[0052] S1. Dissolution: Put 10kg of food-grade anhydrous citric acid crude product into the concentration tank, add 5L of purified water, vacuumize, and continuously feed 0.3MPa steam, heat the feed liquid to 100°C, and stir for 60min;

[0053] S2. Decolorization: add activated carbon with a mass percentage of 0.6% to the solution obtained in S1, vacuumize, slowly introduce 0.3MPa steam, stir at a constant temperature of 100° C. for 1 hour, and filter to obtain a fine filtrate;

[0054] S3. Concentration and crystallization: depressurize the fine filtrate obtained in S2 to -0.09MPa at 70°C, stir at a speed of 33r / min, concentrate for 10h until the specific gravity of the material reaches 1.86g / ml, cool to 40°C, and crystallize 8h to get citric acid wet granules;

[0055] S4. Separation and purification: the wet citric acid granules obtained in S3 were dehydrated, and dried in a vibrating fluidize...

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Abstract

The invention discloses a preparation method and a production device preventing citric acid coagulation. The preparation method comprises the following steps: introducing steam and preparing a citricacid crude product solution, performing decoloration treatment to obtain a fine filtrate, concentrating the fine filtrate to obtain viscous liquid, cooling and crystallizing to obtain wet citric acidparticles, and centrifuging the wet citric acid particles to obtain high-yield and high-purity citric acid crystal particles. In the invention, the preparation technology is optimized; the key point is characterized in that steam is introduced in the preparation process, the problem of citric acid caking in the production process of citric acid and unforeseen circumstances is effectively solved, and blocking of a discharge bottom valve and a pipeline connected with a discharge valve is prevented. Meanwhile, the production technology has the advantages of simplicity, low cost, easiness in operation and implementation, environmental friendliness and safety.

Description

technical field [0001] The invention relates to the technical field of citric acid preparation technology, and more specifically, to a preparation method and production device for preventing citric acid from coagulating. Background technique [0002] The citric acid series of adjuvants have a wide range of uses, and are mainly used as anticoagulants, antacids, and flavoring agents in the pharmaceutical industry. When used as an anticoagulant, calcium ions must participate in the formation of prothrombin activator and the subsequent coagulation process. Citrate ions and calcium ions can form a soluble complex that is difficult to dissociate, thus reducing the concentration of calcium ions in blood and hindering blood coagulation. This product is used as an in vitro anticoagulant during blood transfusion or laboratory blood sample anticoagulation. There is still a gap between the refined citric acid on the market and the standards for medicinal use. The main performance is t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/42C07C51/43C07C51/47C07C59/265B01F7/18B01F1/00B01D9/00B01J3/04
CPCB01D9/0031B01J3/04C07C51/42C07C51/43C07C51/47B01F21/10B01F27/90C07C59/265
Inventor 唐波彭立辉
Owner 湖南新绿方药业有限公司
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