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Biodegradable medical zinc alloy repairing patch as well as preparation method and application thereof

A zinc alloy and patch technology, applied in medical science, tissue regeneration, coating, etc., can solve the problems of inability to obtain therapeutic effect, fast corrosion degradation rate, uneven degradation, etc., to avoid long-term complications and provide good support function, ensure the effect of mechanical properties

Active Publication Date: 2018-11-23
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the magnesium alloy stent obtained in this patent is mainly used in the treatment of airway diseases, and the shape after braiding is tubular, and the research of the present invention finds that not all magnesium alloys can be used for braiding; In the patent, the magnesium alloy wire is prone to uneven degradation during the degradation process, which leads to the early failure of the product due to localized corrosion degradation
In addition, when the magnesium alloy is directly implanted and applied, due to its fast corrosion degradation rate, a better therapeutic effect cannot be obtained.

Method used

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  • Biodegradable medical zinc alloy repairing patch as well as preparation method and application thereof
  • Biodegradable medical zinc alloy repairing patch as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] This embodiment relates to a biodegradable medical zinc alloy patch and its preparation method. The specific preparation method is as follows:

[0043] 1) The thin Zn-Cu alloy wire material with a diameter of 0.07 mm and a circular cross section prepared by the above method is woven into a net on a knitting machine and can be cut arbitrarily.

[0044] 2) After electropolishing and cleaning.

[0045] 3) Degradable coating treatment.

[0046] 4) Dry, package, and sterilize before use.

[0047] The thickness of the final product is 0.1mm, and the area of ​​a single mesh is 0.1mm 2 .

Embodiment 2

[0049] This embodiment relates to a biodegradable medical zinc alloy patch and its preparation method. The specific preparation method is as follows:

[0050] 1) The Zn-Cu-Fe alloy thin wire material whose cross-section is elliptical with a major axis of 0.09 mm and a minor axis of 0.07 mm is prepared by the above method, and is woven into a net on a braiding machine, which can be cut arbitrarily.

[0051] 2) After electropolishing and cleaning.

[0052] 3) Degradable coating treatment.

[0053] 4) Dry, package, and sterilize before use.

[0054] The thickness of the final product is 0.2mm, and the single mesh area is 4mm 2 .

Embodiment 3

[0056] This embodiment relates to a biodegradable medical zinc alloy patch and its preparation method. The specific preparation method is as follows:

[0057] 1) The Zn-Fe-based alloy thin wire material in the shape of a rectangular strip with a long side of 0.4mm and a width of 0.2mm prepared by the above method is woven into a net on a braiding machine and can be cut arbitrarily.

[0058] 2) After electropolishing and cleaning.

[0059] 3) Degradable coating treatment, and then a layer of PLCL absorbable film layer (polylactide-caprolactone copolymer) is laminated.

[0060] 4) After being dried, packaged and sterilized, it is used as a mesh for abdominal wall hernia repair.

[0061] The thickness of the final product is 0.6mm, and the single mesh area of ​​the mesh surface is 10mm 2 .

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Abstract

The invention provides a biodegradable medical zinc alloy repairing patch as well as a preparation method and application thereof, and belongs to the technical field of medical consumables. The biodegradable medical zinc alloy repairing patch is characterized in that zinc alloy wire materials with the cross sections in a round shape, an oval shape or a rectangular (flat strip) shape are used for weaving a porous reticular structure; an absorbable coating is arranged on the reticular structure. The repairing patch can be prepared into different film coated repairing patches through being pressed with an absorbable film layer on the surface, and can be applied to different clinic diseases. The prepared repairing patch has the advantages of low cost, simple processing, low thickness, high toughness, good biocompatibility and the like. After the repairing patch is implanted into the human body, high mechanical property can be maintained in a certain period; meanwhile, after the wound of the patient heals, the patch can be degraded and absorbed by the human body without residue in the body; uncomfortable feeling and untoward effect of the patient in the later period of the healing can be reduced.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a biodegradable medical zinc alloy patch and its preparation method and application, belonging to the technical field of medical consumables. Background technique [0002] Mesh has a wide range of clinical applications in disease treatment and plastic surgery. On the one hand, many disease treatments require the use of tissue repair patches. For example, it is very difficult to repair large tissue defects in the chest wall, abdominal wall, etc., and patches are often used in clinical surgical treatment. Secondly, a hernia means that an organ leaves its original location and enters another location through a weak point or defect or a hole in the human body. Mesh is also needed in the process of surgical treatment. Thirdly, female pelvic floor dysfunction is a gynecological disease with stress urinary incontinence, pelvic organ prolapse and chronic pelvic pain as the main symptoms....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/02A61L31/08A61L31/10A61L31/14A61L27/04A61L27/32A61L27/34A61L27/50A61L27/56A61L27/58
CPCA61L27/042A61L27/047A61L27/32A61L27/34A61L27/50A61L27/56A61L27/58A61L31/022A61L31/086A61L31/10A61L31/14A61L31/146A61L31/148A61L2430/04C08L67/04
Inventor 黄华袁广银
Owner SHANGHAI JIAO TONG UNIV
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