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A kind of biodegradable medical magnesium alloy patch and its preparation method and application

A magnesium alloy and patch technology, which is used in tissue regeneration, medical science, prosthesis, etc., can solve the problems of inability to obtain therapeutic effects, fast corrosion degradation rate, uneven degradation, etc., achieving light weight, low density, and guaranteed mechanical properties. performance effect

Active Publication Date: 2021-08-06
SHANGHAI INNOVATON MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the magnesium alloy stent obtained in this patent is mainly used in the treatment of airway diseases, and the shape after braiding is tubular, and the research of the present invention finds that not all magnesium alloys can be used for braiding; In the patent, the magnesium alloy wire is prone to uneven degradation during the degradation process, which leads to the early failure of the product due to localized corrosion degradation
In addition, when the magnesium alloy is directly implanted and applied, due to its fast corrosion degradation rate, a better therapeutic effect cannot be obtained.

Method used

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  • A kind of biodegradable medical magnesium alloy patch and its preparation method and application
  • A kind of biodegradable medical magnesium alloy patch and its preparation method and application

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Effect test

Embodiment 1

[0042] This embodiment relates to a biodegradable medical magnesium alloy patch and its preparation method. The specific preparation method is as follows:

[0043] 1) The Mg-Zn-Zr filaments with a circular cross-section and a diameter of 0.08 mm prepared by the above method are woven into a net on a braiding machine, which can be cut arbitrarily.

[0044] 2) After electropolishing and cleaning;

[0045] 3) Degradable coating treatment.

[0046] 4) Dry, package, and sterilize before use.

[0047] The final product has a thickness of 0.16 mm and a single mesh area of ​​0.1 mm 2 .

Embodiment 2

[0049] This embodiment relates to a biodegradable medical magnesium alloy patch and its preparation method. The specific preparation method is as follows:

[0050] 1) The Mg-Zn-Gd-based alloy filaments prepared by the above method are elliptical in cross-section, with a major axis of 0.07 mm and a minor axis of 0.05 mm, and are woven into a net on a braiding machine, which can be cut arbitrarily.

[0051] 2) After electrolytic polishing, cleaning.

[0052] 3) Degradable coating treatment.

[0053] 4) Dry, package, and sterilize before use.

[0054] The final product has a thickness of 0.2 mm and a single mesh area of ​​2 mm 2 .

Embodiment 3

[0056] This embodiment relates to a biodegradable medical magnesium alloy patch and its preparation method. The specific preparation method is as follows:

[0057] 1) The cross-sectional shape prepared by the above method is rectangular, the long side is 0.5 mm, and the width is 0.3 mm. The flat strip-shaped Mg-Nd-Zn-Zr filaments are woven into a net on a braiding machine, which can be cut arbitrarily.

[0058] 2) After electrolytic polishing, cleaning.

[0059] 3) Degradable coating treatment, and then press a layer of PLCL absorbable film layer (polylactide-caprolactone copolymer).

[0060] 4) Dried, packaged, and sterilized to be used as a mesh for abdominal wall hernia repair.

[0061] The thickness of the final product is 0.8 mm, and the single mesh area of ​​the mesh surface is 10 mm 2 .

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Abstract

The invention provides a biodegradable medical magnesium alloy patch and its preparation method and application, belonging to the technical field of medical consumables. It is characterized in that it uses magnesium alloy wires with circular, elliptical or rectangular (flat strip) sections to weave into a porous network structure, and the network structure is provided with an absorbable coating. The patch can also be prepared into different patches with a film covering by pressing absorbable film layers, which can be applied to different clinical operation indications. The patch prepared by the invention has the advantages of low thickness, high strength, flexibility and good biocompatibility, and maintains high mechanical properties for a certain period of time after being implanted into the human body, and can be degraded by the human body after the patient's wound heals. Absorption, no residue in the body, reducing the discomfort and adverse reactions of patients in the later stage of healing.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a biodegradable medical magnesium alloy patch and its preparation method and application, belonging to the technical field of medical consumables. Background technique [0002] Mesh has a wide range of clinical applications in disease treatment and plastic surgery. On the one hand, many disease treatments require the use of tissue repair patches. For example, it is very difficult to repair large tissue defects in the chest wall, abdominal wall, etc., and patches are often used in clinical surgical treatment. Secondly, a hernia means that an organ leaves its original location and enters another location through a weak point or defect or a hole in the human body. Mesh is also needed in the process of surgical treatment. Thirdly, female pelvic floor dysfunction is a gynecological disease with stress urinary incontinence, pelvic organ prolapse and chronic pelvic pain as the main symp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/14A61L31/02A61L31/10A61L31/08A61L27/56A61L27/58A61L27/50A61L27/34A61L27/32A61L27/04A61L27/54A61L31/16
CPCA61L27/047A61L27/32A61L27/34A61L27/50A61L27/54A61L27/56A61L27/58A61L31/022A61L31/086A61L31/10A61L31/14A61L31/146A61L31/148A61L31/16A61L2300/102A61L2300/404A61L2300/41A61L2300/412A61L2430/04C08L67/04
Inventor 黄华袁广银
Owner SHANGHAI INNOVATON MEDICAL TECH CO LTD
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