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Anthocyanidin composite tablet able to improve immunotherapy effects for colon cancer and/or rectal cancer

A technology of anthocyanins and composite tablets, which can be used in medical preparations containing active ingredients, pill delivery, drug combinations, etc., can solve problems that have not been reported, and achieve the effect of tumor reduction

Pending Publication Date: 2018-11-23
新疆天健禾牧生物技术有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the method and preparation for the combined use of anthocyanins and probiotics to improve the effect of immunotherapy for colorectal cancer

Method used

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  • Anthocyanidin composite tablet able to improve immunotherapy effects for colon cancer and/or rectal cancer
  • Anthocyanidin composite tablet able to improve immunotherapy effects for colon cancer and/or rectal cancer
  • Anthocyanidin composite tablet able to improve immunotherapy effects for colon cancer and/or rectal cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] This embodiment is the basic characteristics of the invented anthocyanin composite tablet. The formulations of three kinds of anthocyanin compound tablets are shown in Table 1. The anthocyanin dry powder used is blueberry extract dry powder (taken from GNC blueberry essence capsule), wherein the probiotic dry powder contains the following active bacteria: rhamnose milk Bacillus, Lactobacillus acidophilus, Bifidobacterium. The auxiliary materials are micropowder silica gel, PVP, isomaltooligosaccharide. The main characteristics of three kinds of anthocyanin compound tablets are shown in Table 2.

[0035] The formula (mg) of table 1 anthocyanin compound tablet

[0036]

[0037] Table 2 Main characteristics of anthocyanin composite sheet

[0038] formula

[0039] The specific preparation method of anthocyanin-casein microparticles in the above-mentioned embodiment is as follows: the dry powder of anthocyanin extract is dissolved in the citric acid solution ...

Embodiment 2

[0040] Example 2, this example is the invention of the anthocyanin composite tablet for improving the effect of PD-1 immunotherapy for colon tumors

[0041] The tumor model animal used was the MC38 colon cancer mouse model, and the formula used in the preparation was formula A in Example 1. From the first day, according to the anthocyanin 6mg / kg, the formula A (without auxiliary materials) in Example 1 was used to gavage the tumor-bearing mice; on the 7th and 10th days, each mouse was given 200 μg anti- PD-L1 treatment (intraperitoneal injection). Mice that did not receive any treatment were used as the blank control, and mice that received only PD-1 treatment were used as the control. After 16 days of treatment, compared with the control group using only PD-1 in the adjuvant treatment group using formula A (without auxiliary materials) in this example, the tumor volume was reduced by 36%; compared with the blank control group, the tumor volume was reduced by 61% (See figur...

Embodiment 3

[0042] Example 3, this example is the invention of the anthocyanin composite tablet for improving the effect of PD-1 immunotherapy for colon tumors

[0043] The tumor model animal used is the MC38 colon cancer mouse model, and the formula used in the preparation is the formula B in Example 1. From the first day, according to the anthocyanin 6mg / kg, the formula B (without auxiliary materials) in Example 1 was used to gavage the tumor-bearing mice; on the 7th and 10th days, each mouse was given 200 μg anti- PD-L1 treatment (intraperitoneal injection). Mice that did not receive any treatment were used as the blank control, and mice that received only PD-1 treatment were used as the control. After 44 days of treatment, compared with the control group using only PD-1 in the adjuvant treatment group using formula A (without auxiliary materials) in this example, the tumor volume was reduced by 32%; compared with the blank control group, the tumor volume was reduced by 55% .

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Abstract

The invention provides an anthocyanidin composite tablet helping PD-1 monoclonal antibody immunotherapy for colon cancer and rectal cancer with a purpose of enhancing effects of D-1 monoclonal antibody immunotherapy for the colon cancer and rectal cancer. The tablet is prepared from such active constituents as dry powder of extracts of anthocyanidin, casein and dry powder of probiotics, wherein the dry powder of extracts of anthocyanidin mainly contains 3-30% (by mass fraction) of anthocyanidin, non-starch polysaccharides and oligosaccharide and combines with the casein to produce particles; the probiotics include lactobacillus rhamnosus, streptococcus thermophilus, lactobacillus acidophilus, fermented lactic acid bacteria and bifidobacterium. Concerning needs for treatment of the rectalcancer and the colon cancer, the tablet of the invention also uses an ethyl acrylate and methacrylic acid copolymer enteric coating. According to the formula of the tablet of the invention, cancers ofMC38 colon cancer mouse and CT26 colon cancer mouse significantly reduce compared with a contrast group solely taking a PD-1 therapy.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a preparation for intensive immunotherapy for colon cancer and / or rectal cancer and its preparation and application. Background technique [0002] Colon cancer and rectal cancer are malignant tumors that mainly occur in the mucosal epithelium of the colon and rectum, with more than 1 million cases and 500,000 deaths every year. In the 2017.V1 version of the "NCCN Guidelines for the Diagnosis and Treatment of Colorectal Cancer", the immunosuppressive molecules PD-1 monoclonal antibody Pembrolizumab and Nivolumab are recommended for the immunotherapy of colorectal cancer with dMMR / MSI-H molecular phenotype. In a published study of anti-PD-1 immunotherapy (NCT01876511), it was shown that PD-1 monoclonal antibody has made a breakthrough in the immunotherapy of colorectal cancer. [0003] In the adjuvant treatment and postoperative treatment of colon cancer and ...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61K9/32A61K31/352A61P35/00A61K35/741
CPCA61K9/2846A61K31/352A61K35/741A61K38/1709A61P35/00A61K2300/00
Inventor 蒋国强王洛洋汤志刚景楠刘雪润邓蜀江封顺梁伟刘铮
Owner 新疆天健禾牧生物技术有限公司
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