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Gel preparation for treating functional uterine bleeding and application thereof

A technology for uterine bleeding and gel preparations, which is applied in the field of medicine and can solve the problems of gastrointestinal irritation, withdrawal bleeding, and lack of drugs.

Inactive Publication Date: 2018-11-23
张晶
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] But at present, there are few drugs that can be used for the treatment of functional uterine bleeding
In addition, estrogen, androgen, and progesterone drugs are mostly administered orally, and have gastrointestinal stimulating effects, and there are problems such as withdrawal bleeding

Method used

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  • Gel preparation for treating functional uterine bleeding and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 External Gel Preparation for Treatment of Dysfunctional Uterine Bleeding

[0025] Prescription: Alvimopan 200mg, Carbomer 940 1500mg, Propylene Glycol 1500mg, Glycerin 3000mg, Triethanolamine 5000mg, Laurazone 5000mg, add deionized water to a total weight of 100g.

[0026] Preparation method: (1) Take the prescribed amount of Carbomer-940 and add deionized water to prepare a 4% concentrated solution and let it stand overnight to fully swell.

[0027] Then add the prescribed amount of glycerin and triethanolamine to make a gel matrix; (2) Take the prescribed amount of Alvimopan, propylene glycol, and laurocapram into the gel matrix, stir at 800 rpm for 10 minutes, and then add the remaining amount of deionized Stir at 800 rpm for 10 minutes; dispense and serve.

Embodiment 2

[0028] Example 2 External Gel Preparation for Treatment of Dysfunctional Uterine Bleeding

[0029] Prescription: Alvimopan 200mg, Iketoin 600mg, Carbomer 940 1500mg, Propylene Glycol 1500mg, Glycerin 3000mg, Triethanolamine 5000mg, Laurazone 5000mg, add deionized water to a total weight of 100g.

[0030] Preparation method: (1) Take the prescribed amount of Carbomer-940 and add deionized water to prepare a 4% concentrated solution, let it stand overnight, fully swell, and then add the prescribed amount of glycerin and triethanolamine to make a gel matrix; (2) Take Prescription amount of Alvimopan, iketoin, propylene glycol, and laurocapram are added to the gel matrix, stirred at 800 rpm for 10 minutes, then add the remaining amount of deionized gel and stirred at 800 rpm for 10 minutes; dispense and get ready.

Embodiment 3

[0031] Example 3 External Gel Preparation for Treatment of Dysfunctional Uterine Bleeding

[0032] Prescription: Alvimopan 200mg, Iketoin 800mg, Carbomer 940 1500mg, Propylene Glycol 1500mg, Glycerin 3000mg, Triethanolamine 5000mg, Laurazone 5000mg, add deionized water to a total weight of 100g.

[0033] Preparation method: (1) Take the prescribed amount of Carbomer-940 and add deionized water to prepare a 4% concentrated solution and let it stand overnight to fully swell.

[0034] Then add the prescribed amount of glycerin and triethanolamine to make a gel base; (2) Take the prescribed amount of Alvimopan, Icotoin, propylene glycol, and laurocapram into the gel base, stir at 800 rpm for 10 minutes, and then Add the remaining amount of deionization and stir at 800 rpm for 10 minutes;

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Abstract

The invention belongs to the field of medicines, and particularly relates to a gel preparation for treating functional uterine bleeding and application thereof. The gel preparation comprises the following active components of alvimopan or composition of alvimopan and ectoin, wherein the ratio of alvimopan to ectoin in parts by weight is 1:(3 to 5). The gel preparation has the advantages that the function of shortening the bleeding time of the functional uterine bleeding is realized by external administration or local vagina administration; when the alvimopan or the ectoin is singly used, the effect can be realized; when the alvimopan and the ectoin are jointly used, the effect is further improved.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a gel preparation for treating functional uterine bleeding and its application. Background technique [0002] Dysfunctional uterine bleeding is a non-organic uterine bleeding lesion caused by abnormal regulation of the hypothalamus-pituitary-ovarian axis. The disease accounts for about 10% of gynecological outpatients. According to the presence or absence of ovulation, it can be divided into two types: anovulatory and ovulatory. The former is ovulatory dysfunction, which occurs mostly in puberty and menopause; the latter belongs to luteal phase dysfunction, which is mostly in women of childbearing age. More than 80% of patients are anovulatory. Dysfunctional uterine bleeding. According to the stage of onset, the disease can be divided into dysfunctional uterine bleeding in adolescence, dysfunctional uterine bleeding in childbearing age, and dysfunctional uterine bleeding in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/451A61K31/505A61P15/00A61P7/04
CPCA61K9/0034A61K9/06A61K31/451A61K31/505A61K47/32A61P7/04A61P15/00A61K2300/00
Inventor 张晶张玉清李昌生
Owner 张晶
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