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Liver cancer diagnostic markers and diagnostic kits composed of plasma circular RNA

A technology of diagnostic reagents and kits, which is applied in the direction of biochemical equipment and methods, and the determination/testing of microorganisms, can solve the problems of liver cancer diagnostic markers and diagnostic kits that have not been reported, and save time and labor costs. The effect of strong operability and convenient detection

Active Publication Date: 2021-07-09
中国人民解放军海军军医大学第三附属医院
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Problems solved by technology

[0004] However, there are no reports about the diagnostic markers and diagnostic kits for liver cancer composed of plasma circular RNA.

Method used

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  • Liver cancer diagnostic markers and diagnostic kits composed of plasma circular RNA
  • Liver cancer diagnostic markers and diagnostic kits composed of plasma circular RNA
  • Liver cancer diagnostic markers and diagnostic kits composed of plasma circular RNA

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Embodiment 1

[0057] 1. Materials and methods

[0058] (1) Clinical data of patients and collection of liver tissue and plasma

[0059] In the present invention, after approval by the Ethics Committee of Dongfang Hepatobiliary Surgery Hospital Affiliated to Naval Military Medical University and Changhai Hospital and the written consent of each patient, the present invention collected plasma from 163 patients with liver cancer (HCC) from Dongfang Hepatobiliary Surgery Hospital Affiliated to Naval Military Medical University , plasma from 40 cases of HCC after hepatectomy, plasma from 53 healthy people, plasma from 57 patients with chronic hepatitis B (CHB), plasma from 50 patients with liver cirrhosis and 40 For liver cancer and adjacent noncancerous liver (ANL, more than 2 cm away from the tumor edge) tissue, the plasma of 5 patients with liver cancer and 5 patients with chronic hepatitis B was collected from July to August 2016 for the discovery set ( discovery set), and others were colle...

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Abstract

The invention relates to the technical field of biomedical diagnosis, in particular to a hepatocellular carcinoma diagnostic marker combination composed of plasma circular RNA and a kit containing the combination. The liver cancer diagnostic markers include the following circular RNAs: hsa_circ_0000976, hsa_circ_0007750 and hsa_circ_0139897. The invention can be used to distinguish patients with liver cancer from healthy people, patients with chronic hepatitis B or patients with hepatitis B cirrhosis.

Description

technical field [0001] The present invention relates to the technical field of biomedical diagnosis, in particular, a liver cancer diagnostic combination composed of plasma circular RNA, said plasma circular RNA includes hsa_circ_0000976, hsa_circ_0007750 and hsa_circ_0139897, and its use in primary hepatocellular carcinoma Early warning and application of early diagnosis kits. Background technique [0002] Early hepatocellular carcinoma (hepatocellular carcinoma, HCC, hereinafter referred to as liver cancer) often has no obvious symptoms or only presents with atypical symptoms such as fatigue, anorexia, and abdominal distension. When obvious symptoms such as liver pain and hepatomegaly appear, it often means It has reached the middle and late stage, and extrahepatic metastasis has occurred, and the opportunity for radical surgery has been lost. Therefore, for patients with high risk of liver cancer such as chronic hepatitis B, chronic hepatitis C, alcoholic liver disease, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/158C12Q2600/172
Inventor 周伟平余建杨富刘辉郭兴刚杨远徐庆国张潇文
Owner 中国人民解放军海军军医大学第三附属医院
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