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Application of triptorelin

A technology for stress and depression, applied in the field of medicine, to achieve high clinical application value and development prospects, and the effect of significant antidepressant activity

Active Publication Date: 2021-11-02
NANHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report in the literature that triptorelin can treat depression, and based on this, there are related studies on the treatment of central nervous system diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: The effect of triptorelin on the behavior of LPS-induced depression model mice

[0030] Experimental animals: 36 male C57 mice, 3 months old, weighing about 25g. Animals were kept at room temperature (22±2)°C, humidity (45%-65%) and alternating light and dark (12h:12h), with free access to food and water. Animal grouping and treatment Mice were divided into 3 groups according to the random number table method: normal control group (NS, n=12), lipopolysaccharide model group (LPS, n=12), triptorelin (LPS+TRIP, n=12) 12), intraperitoneal injection (i.p) once a day, a total of 1 week of treatment, 1h after the last drug injection, LPS group and LPS+TRIP group intraperitoneal injection of 0.83mg / kg LPS, open field test and Forced to swim for experiments. The result is as figure 1 shown in .

[0031] Since the shortening of the immobility time of animals in the classic animal model of depression may be caused by the central excitatory effect of the drug, the...

Embodiment 2

[0033] Example 2: Effects of Triptorelin on the Behavior of Chronic Restraint Stress (CRS)-Induced Depression Model Mice

[0034] Experimental animals: 36 male C57 mice, 3 months old, weighing about 25g. Animals were kept at room temperature (22±2)°C, humidity (45%-65%) and alternating light and dark (12h:12h), with free access to food and water. Animal grouping and treatment Mice were divided into 3 groups according to random number table method: normal control group (Control, n=12), chronic restraint stress model group (CRS, n=12), triptorelin (CRS+TRIP, n=12), mice with chronic restraint stress were subjected to restraint stress for 6 hours a day, and the stress was continuous for 3 weeks; Drugs were injected 1 hour before the last stress, and the open field test and forced swimming test were performed 24 hours after the last stress. The result is as figure 2 shown.

[0035] The results showed that: in the open field experiment, the activity of the mice in the CRS grou...

Embodiment 3

[0036] Embodiment 3: The effect of triptorelin on the behavior of depression model mice induced by plantar injection of CFA

[0037] Experimental animals: 24 male C57 mice, 3 months old, weighing about 25g. Animals were kept at room temperature (22±2)°C, humidity (45%-65%) and alternating light and dark (12h:12h), with free access to food and water. Animal grouping and treatment Mice were divided into 3 groups according to the random number table method: normal control group (Control, n=8), plantar injection of CFA group (CFA, n=8), triptorelin (CFA+TRIP, n =8), plantar injection of CFA is a classic model of chronic inflammatory pain and depressive behavior; triptorelin once a day i.p, a total of 3 weeks of treatment, open field test and forced swimming started 24 hours after the last drug experiment. The result is as image 3 shown.

[0038] The results showed that in the open field test, there was no difference in the activity of the mice in each group; the plantar injec...

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Abstract

The application belongs to the field of medicine, and discloses the application of triptorelin, especially the application of triptorelin in the preparation of medicaments for treating depression. Experiments have shown that in the forced swimming test, triptorelin can significantly reduce the immobility time of depression model mice induced by chronic restrictive stress, lipopolysaccharide, plantar injection of CFA and early social isolation, indicating that it has a positive effect on depression model mice. Obvious improvement. At the same time, triptorelin can significantly increase the expression of chronic restrictive stress-induced mouse hippocampal BDNF and neuronal synaptic plasticity-related genes c-fos, egr1, arc, npas4. Therefore, triptorelin has significant antidepressant activity, can be used to prepare medicines for treating depression, and has high clinical application value and development prospect.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to the application of triptorelin, in particular to the application of triptorelin in the preparation of medicaments for treating depression. Background technique [0002] Depression is an affective disorder mental disease that seriously affects physical and mental health. It is a group of mood disorders, affective disorders and cognitive disorders caused by various reasons with depression as the main symptom. Depression is characterized by depressed mood, self Situation-centered clinical symptoms are related to biological, psychological and social factors in their occurrence, development and outcome. Depression has a high prevalence rate, high recurrence rate, high disease burden and high suicide mortality rate. According to the Global Burden of Disease Survey, it is estimated that by 2020, depression will become the second largest disease after cardiovascular disease in China. Research on...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/09A61P25/24
CPCA61K38/09A61P25/24
Inventor 曹文宇万炜王贞徐杨牛磊钟小林刘政海
Owner NANHUA UNIV
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