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Production method of high-purity hydrogenated soybean lecithin

A soybean lecithin, catalytic hydrogenation technology, applied in chemical instruments and methods, edible phospholipid composition, organic chemistry, etc., can solve the problems of incomplete hydrogenation, low product purity, low hydrogenation activity, etc., to achieve good catalytic activity and catalytic Selectivity, high product purity, and the effect of lowering the reaction temperature

Inactive Publication Date: 2018-11-16
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0025] The purpose of the present invention is to provide a method for preparing high-purity hydrogenated soybean lecithin in order to solve the problems of low catalytic hydrogenation activity, incomplete hydrogenation and low product purity in the existing preparation of hydrogenated soybean lecithin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Soy Lecithin Hydrogenated

[0050] Weigh 100g of soybean lecithin into the hydrogenation reaction kettle, add 1L of ethanol, add 2g of catalyst Pd / C, seal the reaction kettle, replace the air in the reaction kettle with nitrogen, then replace the nitrogen in the reaction kettle with hydrogen, and finally pass in hydrogen to 0.8 MPa. Stir at a constant temperature of 45° C. in the reaction kettle for 2 hours.

[0051] Purification of Hydrogenated Soy Lecithin

[0052] After the above reaction is finished, the product catalyst is separated, the active carbon is decolorized and then filtered to remove the solvent. Purified by recrystallization with acetone-ethanol binary system, the ratio is 8:1 (volume ratio). After removing the solvent, beating with n-heptane after drying, and then drying to obtain 90 g of hydrogenated soybean lecithin, HPLC purity: 98.2%, iodine value: 1.60.

Embodiment 2

[0054] Soy Lecithin Hydrogenated

[0055] Weigh 100g of soybean lecithin into the hydrogenation reaction kettle, add 1L of ethanol, add 4.0g of catalyst Pd / C, seal the reaction kettle, replace the air in the reaction kettle with nitrogen, then replace the nitrogen in the reaction kettle with hydrogen, and finally pass in hydrogen to 1.6 MPa. Stir at a constant temperature of 55° C. in the reaction kettle for 4 hours.

[0056] Purification of Hydrogenated Soy Lecithin

[0057] After the above reaction is finished, the product catalyst is separated, the active carbon is decolorized and then filtered to remove the solvent. Purified by recrystallization with acetone-ethanol binary system, the ratio is 8:1 (volume ratio). After removing the solvent, beating with n-heptane after drying, and drying to obtain 88g of hydrogenated soybean lecithin, HPLC purity: 98.0%, iodine value: 1.58.

Embodiment 3

[0059] Soy Lecithin Hydrogenated

[0060] Weigh 100g of soybean lecithin into the hydrogenation reaction kettle, add 1L of ethanol, add 1.0g of catalyst Pd / C, seal the reaction kettle, replace the air in the reaction kettle with nitrogen, then replace the nitrogen in the reaction kettle with hydrogen, and finally pass in hydrogen to 0.6 MPa. Stir at a constant temperature of 60° C. in the reaction kettle for 3 hours.

[0061] Purification of Hydrogenated Soy Lecithin

[0062] After the above reaction is finished, the product catalyst is separated, the active carbon is decolorized and then filtered to remove the solvent. Purified by recrystallization with acetone-ethanol binary system, the ratio is 8:1 (volume ratio). After removing the solvent, beating with n-heptane after drying, and then drying to obtain 85 g of hydrogenated soybean lecithin, HPLC purity: 93.0%, iodine value: 4.00.

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Abstract

The invention provides a preparation method applied to catalytic hydrogenation and purification of soybean lecithin. The method comprises the following specific steps: (1) adding soybean lecithin, a catalyst and solvent into a stainless steel reactor, sealing the reactor, filling the reactor with nitrogen to replace the air in the reactor, then filling the reactor with hydrogen to replace the nitrogen in the reactor, and finally maintaining certain hydrogen pressure in the reactor and carrying out constant-temperature reaction; and (2) separating the product from the catalyst after the reaction is completed, adding active carbon and decolorizing, filtering then removing the solvent, re-crystallizing and pulping to obtain high-purity hydrogenated soybean lecithin. The method is capable of preparing the high-purity hydrogenated soybean lecithin; the high-purity hydrogenated soybean lecithin can be used as accessory materials of injection medicines in the pharmaceutical industry; the method is mild in reaction condition and easy to control, and is suitable for industrial large-scale production.

Description

technical field [0001] The invention relates to a production method of high-purity hydrogenated soybean lecithin, which belongs to the field of medicine and chemical industry. Background technique [0002] catalytic hydrogenation [0003] Hydrogenated soybean lecithin is made from soybean lecithin with high iodine value after catalytic hydrogenation and purification. The appearance of this product is light yellow or white powdery solid. After catalytic hydrogenation of soybean lecithin, the unsaturated double bonds in the molecular structure are hydrogenated to open, and the odor is removed. The stability and chemical properties (stability, dispersibility, emulsification) of the product are significantly improved, and it is suitable for low temperature Or store at room temperature for a long time. Hydrogenated soybean lecithin is widely used in food, health products, advanced cosmetics, pharmaceutical manufacturing, and light industry. [0004] Due to technical limitatio...

Claims

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Application Information

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IPC IPC(8): C07F9/10
CPCC07F9/103
Inventor 李玉艳冯海威刘正世李佳
Owner CHINA PHARM UNIV
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