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Traditional Chinese medicine for preventing and treating hashimoto thyroiditis and application thereof

A technology of Hashimoto's thyroiditis and traditional Chinese medicine is applied in the field of traditional Chinese medicine for preventing and treating Hashimoto's thyroiditis, which can solve the problems of many adverse reactions, poor curative effect of patients' systemic symptoms, and lack of immune regulation of hormones.

Inactive Publication Date: 2018-11-16
上海复活石医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, Western medicine mainly uses thyroxine replacement therapy, immunotherapy and surgery to relieve the local symptoms of the thyroid gland, but the curative effect on the systemic symptoms of patients is not good.
Among them, the most conventional therapy is hormone replacement therapy, and hormones have no immunomodulatory effect and cannot reduce the titer of thyroid autoantibodies, and patients need to take medication for life
Secondly, patients need continuous physical examinations, and adjust the dosage of hormones according to the indicators of thyroid function. There are many adverse reactions, and drug withdrawal is easy to repeat.

Method used

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  • Traditional Chinese medicine for preventing and treating hashimoto thyroiditis and application thereof
  • Traditional Chinese medicine for preventing and treating hashimoto thyroiditis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: oral liquid

[0018] The raw materials are taken according to the following weight proportions: 400 grams of Chuan Fritillaria (or Yi Fritillaria), 100 grams of Sarsaparilla, 50 grams of Tripterygium wilfordii, and 100 grams of Prunella vulgaris. Add water to decoct the above 2 flavors twice, count from boiling, each time for 1 hour, add 10 times the amount of water for the first time, add 8 times the amount of water for the second time, after the decoction is completed, combine the two decoction liquids, and let cool 3000rpm Centrifuge for 10 minutes, remove the supernatant, concentrate, then add suitable auxiliary materials, make 1L of oral liquid according to the existing known method, and divide it into 10ml per bottle to get it. Oral 3 times a day, 1 bottle each time.

Embodiment 2

[0019] Embodiment 2: Granules

[0020] The raw materials are taken according to the following weight proportions: 400 grams of Chuan Fritillaria (or Yi Fritillaria), 100 grams of Sarsaparilla, 200 grams of Tripterygium wilfordii, and 200 grams of Prunella vulgaris. Add water to decoct the above 2 flavors twice, count from boiling, each time for 1 hour, add 10 times the amount of water for the first time, add 8 times the amount of water for the second time, after the decoction is completed, combine the two decoction liquids, and let cool 3000rpm Centrifuge for 10 minutes, remove the supernatant, concentrate to an extract with a specific gravity of 1.35, add appropriate amount of dextrin and powdered sugar, dry at 70°C, make granules of 1000 g, granulate, and pack in 5 g per bag to obtain , orally 3 times a day, 1 bag each time.

Embodiment 3

[0021] Embodiment 3: tablet

[0022] The raw materials are taken according to the following weight proportions: 400 grams of Chuan Fritillaria (or Yi Fritillaria), 200 grams of Sarsaparilla, 300 grams of Tripterygium wilfordii, and 300 grams of Prunella vulgaris. Add water to decoct the above eleven flavors twice, count from boiling, each time for 1 hour, add 10 times the amount of water for the first time, add 8 times the amount of water for the second time, after the decoction is completed, combine the two decoction liquids, and let it cool Centrifuge at 3000rpm for 10 minutes, take the supernatant, reduce concentration to a dry paste, and then make tablets according to the known method in the prior art, each tablet is 0.3 g, orally 3 times a day, 3 tablets each time.

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Abstract

The invention discloses a traditional Chinese medicine for preventing and treating hashimoto thyroiditis. The traditional Chinese medicine for preventing and treating hashimoto thyroiditis is composedof the following raw medicinal materials (by weight): 1-10 parts of Fritillaria cirrhosa (or Fritillaria pallidiflora Schrek), 0-10 parts of chinaroot greenbrier, 0-10 parts of Tripterygium wilfordiiHook f, and 0-10 parts of prunella vulgaris. In addition, the invention also discloses application of the traditional Chinese medicine in the preparation of drugs and health products for preventing and treating hashimoto thyroiditis. It shows through laboratory animal and clinical test that the traditional Chinese medicine has good safety and excellent curative effect and can effectively treat hashimoto thyroiditis. The traditional Chinese medicine has a good effect of improving clinical symptoms, has little toxic and side effect and has a good clinical application prospect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and specifically relates to a traditional Chinese medicine for preventing and treating Hashimoto's thyroiditis. In addition, the invention also discloses the application of the traditional Chinese medicine. Background technique [0002] Hashimoto's thyroiditis (HT for short), also known as chronic lymphocytic thyroiditis (CLT), autoimmune thyroiditis and Hashimoto's thyroiditis. HT is a chronic autoimmune disease with autoimmune thyroid tissue as antigen and thyroglobulin antibody (Thyroglobulin Antibody, TgAb) and thyroid peroxidase antibody (Thyroid Peroxidase Antibody, TPOAb) as antibodies. Hypothyroidism is the most common cause of HT. It is an immune disease characterized by a large number of lymphocytes infiltrating the thyroid tissue and destruction of follicular cells. Serological tests show thyroid peroxidase antibody (TPOAb), thyroglobulin Significant elevation of antibody ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61K36/90A61P5/14A61P37/02
CPCA61K36/37A61K36/536A61K36/896A61K36/8966A61K36/90A61P5/14A61P37/02A61K2300/00
Inventor 杨茗橘程芬
Owner 上海复活石医药科技有限公司
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