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Quality control product for biochemical detection and quality control method

A technology of biochemical testing and quality control products, applied in the field of medical testing, can solve the problems of lack, waste, and nowhere to use serum, etc., and achieve the effects of long precision between batches, avoiding waste, and avoiding matrix effects

Inactive Publication Date: 2018-11-13
ZHEJIANG PROVINCIAL PEOPLES HOSPITAL
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Problems solved by technology

However, in the existing clinical biochemical quality control products, some or all of these five substances are missing, and there are deficiencies
On the other hand, the existing quality control products are mainly derived from animal serum, which is different from clinical test samples, and is prone to matrix effects (matrix effects are the influence of components other than the analyte in the sample on the analysis process of the analyte), However, the remaining serum of clinical biochemical tests has nowhere to be used, which is a serious waste

Method used

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  • Quality control product for biochemical detection and quality control method

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Embodiment

[0034] 1) Configure reagents for backup

[0035] Prepare 10mmol / L sodium bicarbonate solution, 10mmol / L Na 2 - EDTA solution (pH=8.0), 50vol% ethanol solution and 0.2wt% sodium azide solution.

[0036] 2) Dialysis bag processing

[0037] a) Cut the dialysis bag into small pieces (choose the size according to your needs). Since the dialysis bag is easily contaminated by cellulose-decomposing microorganisms, gloves must be worn during operation;

[0038] b) wet the dialysis membrane in excess 10mmol / L sodium bicarbonate solution, and boil for 10 minutes;

[0039] c) Put the dialysis membrane in 10mmol / L Na 2 -Boil in EDTA solution (pH=8.0) for 10 minutes;

[0040] d) repeat the operations in b) and c) once;

[0041] e) wash several times with distilled water;

[0042] f) Store at 4°C in 20%-50% ethanol to prevent the growth of cellulolytic microorganisms.

[0043] 3) Preparation of low-value quality control products

[0044] S1. From the remaining serum samples of clini...

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Abstract

The invention relates to a quality control product for biochemical detection and a quality control method. The quality control product has the beneficial technical effects that (1) the quality controlproduct for biochemical detection is prepared by using the serum of a healthy person as the raw material, and is consistent with a clinical detection sample, so that while the matrix effect is furthest avoided, the qualifies of the five biochemical detection indexes (ADA (adenosine deaminase), AFU (alpha-fucosidase), DBIL (direct bilirubin), GPDA (glycyl-proline-dipeptidyl aminopeptidase) and TBA(total bile acid)) are effectively controlled, and the defect of lack of part or all of five substances in the existing quality control product is overcome; (2) by using the serum of the healthy person as the raw material, the waste due to no use of a large amount of remaining serum in the clinical biochemical inspection is avoided, and a large amount of original wasted serum resources is saved;(3) the quality control product for biochemical detection is prepared by scientific design, so that the good within-run accuracy and between-run accuracy and the longer stability are realized under the reasonable preservation condition, and the quality control product is suitable for being applied in clinics.

Description

technical field [0001] The invention relates to the technical field of medical testing, in particular to a biochemical detection quality control product and a quality control method capable of effectively controlling the detection of five clinical biochemical detection indicators of ADA, AFU, DBIL, GPDA and TBA. Background technique [0002] At present, commercial quality control products are often used in the field of clinical testing for daily indoor quality control and monitoring the precision of the detection system. [0003] ADA, AFU, DBIL, GPDA, and TBA are five important indicators of clinical biochemical tests. However, some or all of these five substances are missing in the existing clinical biochemical quality control products, and there are deficiencies. On the other hand, the existing quality control products are mainly derived from animal serum, which is different from clinical test samples, and is prone to matrix effects (matrix effects are the influence of co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/50
CPCG01N33/50
Inventor 夏骏叶德力孙汝林徐菲张玉霞
Owner ZHEJIANG PROVINCIAL PEOPLES HOSPITAL
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