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Method and device for manufacturing one-time molded tissue chip receptor wax piece

A technology of tissue chip and wax block, which is applied in the production of tissue chip and biomedical field. It can solve the problems of large differences between batches, restrictions on the promotion and application of tissue chip technology, and the limitation of tissue chip technology, so as to achieve strict control and eliminate wax. The effect of block cracking and overcoming technical obstacles

Pending Publication Date: 2018-11-13
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Moreover, the only imported prefabricated receptor wax block currently on sale in the world is extremely expensive (about 600 yuan / piece), and the self-made wax block lacks uniform standards and devices, and there are cumbersome steps in production, poor quality, and batch production. These shortcomings make the development and application of tissue chip technology face great restrictions, and restrict the promotion and application of tissue chip technology.

Method used

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  • Method and device for manufacturing one-time molded tissue chip receptor wax piece
  • Method and device for manufacturing one-time molded tissue chip receptor wax piece
  • Method and device for manufacturing one-time molded tissue chip receptor wax piece

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Embodiment Construction

[0053] In the present invention, it should be understood that if the terms "front, back, left, right" etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, it is only for the convenience of describing the present invention and simplifying the description. It does not indicate or imply that the device or element referred to must have a specific orientation, be constructed or operated in a specific orientation, so the positional relationship is used as an example and cannot be construed as a limitation on this patent;

[0054] A mold device for making a tissue chip acceptor wax block at one time, comprising a rectangular groove cofferdam 1 with groove holes 11, an array grid guide hole structure 2 and a columnar array grid 3;

[0055] The array grid guide hole structure 2 cooperates with the columnar array grid 3, the array grid guide hole structure 2 moves linearly up and down on the cylindrical matrix...

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Abstract

The invention discloses a device for manufacturing a one-time molded tissue chip receptor wax piece. The device comprises a rectangular recess cofferdam, an array grid guide hole structure and a columnar array grid, wherein a recess hole is formed in the rectangular recess cofferdam; the array grid guide hole structure is matched with the columnar array grid; the array grid guide hole structure ismoved in an up and down straight line manner on a columnar matrix of the columnar array grid through a lifting device; the array grid guide hole structure, the column matrix of the columnar array grid and the recess hole above form a cofferdam type wax holding mold cavity with the array grid guide hole structure as a bottom. By adopting the device, an axial position of the columnar array grid canbe effectively confirmed, on the basis of one-time molding, a hole drilling depth can be strictly controlled, strict control on precision can be achieved, and problems that in the prior art, breakage, burring, cracking and large batch differences in a receptor wax piece manufacturing process can be solved.

Description

technical field [0001] The invention relates to an important experimental method and device in the field of biomedicine, which is used for preparing a once-formed tissue chip acceptor wax block, and belongs to the technical field of tissue chip production. Background technique [0002] Tissue chip technology (tissue chip), also known as tissue microarray (tissue microarray, TMA), can orderly arrange dozens to hundreds of tiny pathological tissues on a glass slide, and then make high-throughput pathological tissues slice. In recent years, tissue chip technology is another biochip technology emerging after gene chips and protein chips, which can be used to study the expression of the same gene or protein in different cells or pathological tissues, and the relationship between it and clinical characteristics. It has many advantages such as high throughput, large sample, high efficiency, and low cost. At the same time, it can reduce the damage to the original tissue wax block a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/36
CPCG01N1/36G01N2001/368
Inventor 孙冉冉任志刚余祖江阚全程崔光莹余炎何玉婷李娟罗永刚李红强韩奇财李超陈宇
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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