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Immune cell with tumor treatment function and application thereof

A technology for immune cells and tumor treatment, applied in the field of immune cells and its applications, can solve the problems of unsatisfactory and limited tumor treatment effects, achieve the effect of enhancing anti-tumor effect and increasing the number of infiltration

Inactive Publication Date: 2018-11-06
广州沙艾生物科技有限公司
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Problems solved by technology

[0005] In view of current chemotherapy, radiotherapy, surgery and other treatment methods for the treatment of tumors and cancers, the scope of treatment is still relatively limited, and the treatment effect on some tumors is still not ideal. The purpose of the present invention is to provide a tumor treatment function immune cells and their applications

Method used

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  • Immune cell with tumor treatment function and application thereof
  • Immune cell with tumor treatment function and application thereof

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Embodiment 1

[0030] In this example, the anti-tumor effect of "virus-gene" therapy combined with immune cell therapy, as well as the anti-tumor effect of the combined related mechanism, was studied through in vitro and in vivo experiments; CIK) and the combined treatment group (AdCN215-GFP and CIK, AdCN215-IL18 and CIK) were compared to examine the therapeutic effect and effect of oncolytic adenovirus genetically modified with interleukin 18 on liver tumors using CIK cells as a carrier . details as follows:

[0031] An immune cell with tumor therapy function

[0032] Virus preparation and titer determination

[0033] Double regulation type 5 oncolytic adenovirus AdCN215-GFP; non-replicating type 5 adenovirus Ad-EGFP1 was constructed and preserved by itself. Lentiviral backbone plasmid pCDH-EF1α was purchased from addgene, lentiviral packaging plasmids pMD2.G, pMDLg / pRRE and pRSV-Rev were purchased from Addgene; PGL3-basic plasmid expressing Luciferase gene was from Promega. The plasmid...

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Abstract

The invention relates to an immune cell with a tumor treatment function and application thereof. The immune cell provided by the invention is an exogenously infused immune cell; the immune cell has acapability of inhibiting tumor together with oncolytic adenovirus, an immune microenviroment of tumor is firstly broken, an inflammation environment is caused, then the immune cell can take functionsinto play well in the inflammation environment, and a tumor treatment effect can be thus improved; the immune cell is a cytotoxic T cell (CTL), a dendritic cell, a cell factor induced killer cell (CIK) or a tumor infiltration lymphocyte (TIL). The immune cell is combined with the oncolytic virus in oncolytic virus mediated gene therapy, then tumor inhibition can be further relieved, anti-tumor immunoreactions can be enhanced, and the purposes of improving immunity of a patient self and treating tumor can be achieved.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to an immune cell with tumor treatment function and its application. Background technique [0002] Nowadays, diseases such as tumor and cancer have become major diseases that threaten human health and are one of the main causes of human death. According to statistics, in 2015, there were 14.1 million new cancer cases worldwide and 8.2 million people died of cancer. It is expected that the number of new cases will increase by 70% in the next 20 years. Due to factors such as an aging population, bad living habits, environmental pollution and the low cure rate of traditional methods, my country has become a country with a large number of cancer incidence and deaths. According to statistics from the National Cancer Registry, in 2015, there were 4,291,600 new cancer cases and 2,814,200 deaths in China. Among them, lung cancer and gastric cancer are the top two in terms of incidence and dea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/0783A61K35/17A61P35/00
CPCC12N5/0638A61K35/17A61P35/00C12N5/0646
Inventor 徐智峰张新
Owner 广州沙艾生物科技有限公司
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