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Application of chlorogenic acid and composition thereof for preparing medicines for treatment of squamous-cell carcinoma

A technology of squamous cell carcinoma and chlorogenic acid, applied in medicine, in the field of preparation of medicine for treating squamous cell carcinoma, achieving the effect of excellent application prospect

Active Publication Date: 2018-10-23
SICHUAN JIUZHANG BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the treatment of squamous cell carcinoma with chlorogenic acid and coumaroylquinic acid

Method used

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  • Application of chlorogenic acid and composition thereof for preparing medicines for treatment of squamous-cell carcinoma
  • Application of chlorogenic acid and composition thereof for preparing medicines for treatment of squamous-cell carcinoma
  • Application of chlorogenic acid and composition thereof for preparing medicines for treatment of squamous-cell carcinoma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1 pharmaceutical composition oral preparation prescription of the present invention

[0030] 1. Prescription 1

[0031] Chlorogenic acid 1000g, coumaryl quinic acid 1g.

[0032] Preparation method: Aseptically weigh chlorogenic acid and coumaroylquinic acid according to the prescription, mix them evenly, and aseptically pack them into powders.

[0033] 2. Prescription II

[0034] Chlorogenic acid 1000g, coumaryl quinic acid 5g, filler 500g, binder 5g.

[0035] Preparation method: Weigh chlorogenic acid, coumaroylquinic acid, filler and binder according to the prescription, granulate, granulate, and pack into granules.

[0036] 3. Prescription Three

[0037] Chlorogenic acid 1000g, coumaryl quinic acid 1g, filler 500g, binder 5g, lubricant 3g.

[0038] Preparation method: Weigh chlorogenic acid, coumaroylquinic acid, filler and binder according to the prescription, granulate, granulate, add lubricant, compress into tablets to obtain tablets.

[0039] The...

Embodiment 2

[0040] Embodiment 2 Pharmaceutical composition injection preparation prescription of the present invention

[0041] 1. Prescription 1

[0042] Chlorogenic acid 1000g, coumaryl quinic acid 1g.

[0043] Preparation method (1): Aseptically weigh chlorogenic acid and coumaroylquinic acid according to the prescription, mix them evenly, and aseptically subpackage them into powder injections.

[0044] Preparation method (2): Weigh chlorogenic acid and coumaroylquinic acid according to the prescription, dissolve them in water for injection, filter and sterilize, and freeze-dry to obtain a freeze-dried powder injection.

[0045] 2. Prescription II

[0046] Chlorogenic acid 1000g, coumaryl quinic acid 1g, scaffolding agent 2667g, antioxidant 67g.

[0047] Preparation method: Weigh chlorogenic acid, coumaroylquinic acid, scaffolding agent and antioxidant according to the prescription, dissolve in water for injection, filter and sterilize, freeze-dry to obtain freeze-dried powder injec...

experiment example 1

[0050] Experimental example 1. In vitro test of chlorogenic acid and chlorogenic acid composition in inhibiting squamous cell tumor

[0051] 1 material

[0052] 1.1 Cell Tissue Human skin squamous cell carcinoma A431 cell line was purchased from Wuhan Punuosai Life Science and Technology Co., Ltd.

[0053] 1.2 Drug chlorogenic acid, coumaroylquinic acid, composition 1 of chlorogenic acid and coumaroylquinic acid (100:10), composition 2 of chlorogenic acid and coumaroylquinic acid (100:5) , chlorogenic acid and coumaroylquinic acid composition 3 (100:1), chlorogenic acid and coumaroylquinic acid composition 4 (100:0.1), chlorogenic acid and coumaroylquinic acid combination Material 5 (100:0.01); provided by Sichuan Jiuzhang Biotechnology Co., Ltd.

[0054] 1.3 Reagents Dimethyl sulfoxide (DMSO), tetramethylazolium salt (MTT), IMDM culture medium, fetal calf serum, and propidium iodide (PI) were provided by Sigma.

[0055] 2 methods

[0056] 2.1 Cell culture

[0057] The A4...

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Abstract

The invention discloses an application of chlorogenic acid or coumaroyl guinic acid in preparation of medicines for treatment of squamous-cell carcinoma and provides a chlorogenic acid composition andan application thereof for treatment of the squamous-cell carcinoma. The chlorogenic acid and coumaroyl guinic acid can effectively treat the squamous-cell carcinoma; by combining the two components,a composition can effectively treat the squamous-cell carcinoma with synergistic effect, so that the products have excellent application prospect.

Description

technical field [0001] The present invention specifically relates to the use of chlorogenic acid in preparing medicine for treating squamous cell carcinoma; the invention also relates to the use of chlorogenic acid composition in preparing medicine for treating squamous cell carcinoma. Background technique [0002] Squamous cell carcinoma (scc), referred to as squamous cell carcinoma, is a malignant tumor originating from epidermal keratinocytes or skin appendages. It is one of the most common skin malignancies clinically, accounting for 20% of all skin malignancies, according to According to the location of the disease, it can be divided into head and neck squamous cell carcinoma, skin squamous cell carcinoma, oral squamous cell carcinoma, esophageal squamous cell carcinoma, cervical squamous cell carcinoma, and vaginal squamous cell carcinoma. Although the mortality rate is not high, the treatment cost is relatively high. The male to female incidence ratio of SCC in my co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61P35/00
CPCA61P35/00A61K31/216
Inventor 张洁陈晓光黄望
Owner SICHUAN JIUZHANG BIO TECH CO LTD
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