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A traditional Chinese medicine composition for treating ulcerative colitis and its preparation method

A technology for ulcerative colitis and a composition is applied in the field of traditional Chinese medicine compositions for the treatment of ulcerative colitis and the field of preparation thereof, which can solve the problems of large dosage, large side effects, and difficulty in solving UC symptoms, and achieves an obvious therapeutic effect. Effect

Active Publication Date: 2020-12-01
XINJIANG MEDICAL UNIV
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  • Abstract
  • Description
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Problems solved by technology

[0003] It has been proved by literature that the generation of UC is mainly related to NF-κB and HuR phosphorylation levels, IL-1α, IL-1β, IL-10, IL-17, TNF-α and other cytokines (Gan Huatian, Ouyang Qin et al. Ulcer Nuclear factor-κB activation and cytokine gene expression in patients with acute colitis. Chinese Journal of Internal Medicine, 2002, 41(4): 252-255). Treatment, mainly oral decoction plus enema, or application of Dijincao, Geranium, Gynostemma, Radix Paeoniae Rubra, Stir-fried Atractylodes Rhizome, Psoralen, Yuanhu, Licorice and other medicines, it is not difficult to find that it has certain limitations, some medicines The amount is large, and some side effects are large, it is difficult to solve UC diseases from the genetic level

Method used

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  • A traditional Chinese medicine composition for treating ulcerative colitis and its preparation method
  • A traditional Chinese medicine composition for treating ulcerative colitis and its preparation method
  • A traditional Chinese medicine composition for treating ulcerative colitis and its preparation method

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preparation example Construction

[0032] The present invention also provides a preparation method of a Chinese medicine composition for treating ulcerative colitis, comprising the following steps:

[0033] 1) Pulverize amber, Tianzhuhuang, pomegranate flower, red stone fat, coptis, ginseng, gall, blood dried, plantain and quince, and pass through a 80-120 mesh sieve to obtain powdered amber, Tianzhuhuang, Pomegranate flower, red stone fat, berberine, ginseng, gall, dried blood, plantain and quince;

[0034]2) extracting the powdered quince seed and psyllium seedling, and collecting the medicinal solution;

[0035] 3) Mix the liquid medicine described in step 2) with powdered amber, geranium yellow, pomegranate flower, red stone fat, berberine, ginseng, gall and dried blood in a volume-to-mass ratio of 2-4:0.36-0.72.

[0036] In the present invention, amber, tianzhuhuang, pomegranate flower, red stone fat, coptis, ginseng, gall, dried blood, plantain and quince are respectively pulverized to obtain the pulveri...

Embodiment 1

[0042] Weigh 20g of amber, 20g of Tianzhuhuang, 20g of pomegranate, 15g of red stone fat, 15g of coptis, 15g of ginseng, 15g of gall, 10g of blood, 10g of quince and 20g of plantain, crush them respectively and pass through a 100-mesh sieve. Mix quince seeds and plantain seeds and extract them in 150ml of rose water for 5 hours, collect the filtrate after filtration, add 0.36g of amber, geranium yellow, pomegranate flower, red stone fat, berberine, and boxing ginseng to each 2ml of filtrate , gallate, and dried blood are thoroughly mixed to prepare a traditional Chinese medicine composition for treating ulcerative colitis.

Embodiment 2

[0044] Weigh 15 amber, 15g Tianzhuhuang, 15g pomegranate flower, 10g red stone fat, 10g coptis, 10g ginseng, 10g gall, 8g blood, 8g quince seed and 15g plantain seed, crush them respectively and pass through a 100-mesh sieve. Mix quince seeds and plantain seeds and extract them in 70ml of rose water for 6 hours, collect the filtrate after filtration, add 0.36g of amber, geranium yellow, pomegranate flower, red stone fat, berberine, and boxing ginseng to each 2ml of filtrate , gallate, and dried blood are thoroughly mixed to prepare a traditional Chinese medicine composition for treating ulcerative colitis.

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Abstract

The invention provides a traditional Chinese medicine composition for treating ulcerative colitis, which belongs to the field of traditional Chinese medicine preparations. The traditional Chinese medicine composition provided by the invention contains the following raw materials in parts by weight: 15 to 25 parts of amber, 15 to 25 parts of Tianzhu Huang, 15 to 25 parts of pomegranate flowers, 10 to 20 parts of red stone resin, 10 to 20 parts of coptis, and boxing. 15 to 25 portions of ginseng, 10 to 20 portions of gallic seeds, 8 to 12 portions of blood root, 15 to 25 portions of plantain seeds, and 8 to 12 portions of quince seeds. The traditional Chinese medicine composition provided by the present invention has obvious therapeutic effect on rats with ulcerative colitis modeled by TNBS. Through the maximum tolerated dose test in mice, no mice died, which preliminarily confirms that the traditional Chinese medicine composition of the present invention is safe and effective.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine composition for treating ulcerative colitis and a preparation method thereof. Background technique [0002] Ulcerative colitis (UC), also known as chronic nonspecific ulcerative colitis, is mostly located in the rectum and sigmoid colon, and can also spread to the descending colon or even the entire colon. The whole clinical symptoms are diarrhea, pus and blood in the stool, abdominal pain and tenesmus. Modern medicine believes that the abnormality of autoimmune cells leads to the destruction of mucous membranes, or the disturbance of cerebral cortex and autonomic nerve dysfunction due to mental factors, resulting in intestinal hypermotility, spasm and contraction of intestinal vascular smooth muscle, tissue ischemia, and capillary permeability Increase, thereby forming inflammation, erosion and ulcer of intestin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61P1/04A61P1/00A61K35/10A61K35/64A61K33/26
CPCA61K36/889A61K36/896A61K36/899A61P1/00A61P1/04A61K33/26A61K35/10A61K35/63A61K36/185A61K36/68A61K36/704A61K36/718A61K36/73A61K2300/00
Inventor 库热西·玉努斯张景萍卡思木江·阿西木江
Owner XINJIANG MEDICAL UNIV
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