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Glabridin composition and preparation method thereof

The technology of glabridin and composition is applied in the field of novel glabridin compound whitening composition and preparation thereof, and can solve the problems of poor solubility of glabridin, brown yellow skin, unstable load, etc. The effect of lightening dark spots, cleaning and purifying environmental pollution

Inactive Publication Date: 2018-10-09
亿利耐雀生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor solubility of glabridin in water, the method uses a water solvent as an efficient extractant.
In addition, the rigid structure of β-cyclodextrin as a carrier itself is poor, and the load is unstable
[0007] So far, a variety of whitening ingredients or compositions have been developed, but in some cases, the effect of trying a whitening ingredient is not obvious, and various whitening compositions fail to produce people's expected effects and in some cases side effects
For example, some traditional whitening agents such as hydroquinone and kojic acid have been proven to have strong whitening effects, but with the deepening of research, researchers have found that long-term use of hydroquinone can cause brown and yellow disease and dull skin, and even Carcinogenic risk, so in Europe and China, hydroquinone is banned for use on the skin

Method used

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  • Glabridin composition and preparation method thereof
  • Glabridin composition and preparation method thereof
  • Glabridin composition and preparation method thereof

Examples

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Effect test

preparation example 1

[0051] Preparation Example 1: In parts by weight, dissolve 1 part of dried medicinal dregs of Glycyrrhiza glabra after extracting glycyrrhizic acid into 10 parts of ethyl acetate, slowly add 10 parts of γ-cyclodextrin, heat and reflux for extraction for 4 hours , filtered while it was hot, let the filtrate cool to room temperature, precipitated crystals, filtered, and dried the crystals to obtain a water-soluble glabridin carrier. The content of glabridin was determined, and its content was greater than the commercially available specification of 40% glabridin in the product content.

[0052] 2.2 Preparation of glabridin composition

Embodiment 1

[0053] Example 1: Weigh 5 parts of glabridin carrier, 2 parts of nicotinamide, 1.5 parts of undecylenoyl phenylalanine, 1 part of trisodium ascorbyl palmitate phosphate, α-lipoic acid 0.5 part of the mixture is placed in a mortar, ground and pulverized, and passed through a 100-mesh sieve to obtain a fine powder and obtain a glabridin composition.

Embodiment 2

[0054] Example 2: Weigh 3 parts of glabridin carrier, 2.5 parts of nicotinamide, 2 parts of undecylenoyl phenylalanine, 2 parts of trisodium ascorbyl palmitate phosphate, α-lipoic acid prepared by the above method 1.1 0.5 part of the mixture is placed in a mortar, ground and pulverized, and passed through a 100-mesh sieve to obtain a fine powder and obtain a glabridin composition.

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Abstract

The invention discloses a glabridin composition and a preparation method thereof. The glabridin composition comprises glabridin, undecylenoyl phenylalanine, nicotinamide, ascorbyl palmitate phosphatetrisodium, and alpha-lipoic acid. The glabridin composition reduces the production of dopachrome by inhibiting the activity of tyrosinase during the process of forming dopaquinone from tyrosine, blocks the melanin transfer pathway, and accelerates the exfoliation of stratum corneum and metabolism, so as to achieve beauty effects such as whitening and freckle removing.

Description

technical field [0001] The invention relates to a composite whitening composition and a preparation method thereof, in particular to a novel glabridin composite whitening composition applied to cosmetics and a preparation method thereof. Background technique [0002] With the improvement of modern living standards, people are increasingly pursuing healthy and fair skin, which makes the demand for whitening products more and more large. Skin color is produced by the complex combination of skin physiological surface state, blood flow, moisture, pigment and other components. Among a series of factors, melanin is the most important. Therefore, whitening mainly regulates the production and distribution of melanin. [0003] During the formation of melanin, the tyrosine present in the melanocyte tissue is gradually converted into pure melanin and pheomelanin under the action of tyrosine, and then the melanocyte tissue transfers the melanin to the basal layer cells of the epidermis....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/44A61K8/49A61K8/67A61Q19/02
CPCA61K8/44A61K8/498A61K8/673A61K8/675A61K8/676A61K2800/782A61Q19/02
Inventor 魏元刚许慧刘亿宁杨永安钟慧
Owner 亿利耐雀生物科技有限公司
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