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Preparation method of tablets for treating depression

A preparation process, a technology for depression, which is applied in the field of drug preparation, can solve the problems of many components of traditional Chinese medicine, increase the difficulty of obtaining raw materials, and loss, and achieve the effects of reasonable components and content, clear pharmacological effects, and low cost

Inactive Publication Date: 2018-09-21
仁和堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both CN201510336203 and CN201510336115 use western medicine mianserin hydrochloride as the main supplement and Chinese herbal medicine to make compound medicine to treat depression, which reduces the side effects and dependence produced by western medicine, and has remarkable curative effect. The difficulty of obtaining, and once one or a few kinds of raw materials are in short supply, the enterprise will stop production, resulting in greater losses

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A preparation process for a tablet for the treatment of depression, comprising the steps of:

[0022] Preparation of ginseng extract: Put ginseng into a pulverizer and crush it, pass through a 50-mesh sieve, then add it to 10 times the weight of water, heat to 70°C, keep it warm for 1 hour, and collect the filtrate; put the filtrate in a vacuum concentrator, vacuum Concentrate to one-third of the volume of the filtrate; add alcohol so that the alcohol content in the concentrate reaches 75% (v / v), let it stand for 1 hour, filter and collect the filtrate, remove the ethanol by rotary evaporation under reduced pressure, and dry at low temperature to obtain Ginseng extract;

[0023] Preparation of tangerine peel extract: get tangerine peel, pulverize, pass through a 200-mesh sieve to obtain tangerine peel powder, put it in a reaction kettle, then add five times the weight of 85% ethanol for extraction three times, each time for 6h, then combine three extractions, Concentra...

Embodiment 2

[0039] Acute toxicity test: first, the tablet prepared in Example 1 was dissolved in physiological saline, stirred evenly, and the concentration was controlled at 1 mg / mL. 20 Kunming mice, half male and half male, were used for acute toxicity test. The mice were randomly divided into two groups, 10 in each group; before the experiment, they were fasted for 12 hours, and the drug solution was administered by gavage; Continuously observe for two weeks after taking the medicine, and record the number of toxic reactions and deaths of the mice. The results of the experiment showed that compared with the control group, there was no significant difference in the mice after administration. The experiment was observed for two consecutive weeks, and there was no obvious abnormality in the general condition, diet, drinking water, and weight gain of the mice.

[0040] Long-term toxicity test: first, the tablet prepared in Example 1 was dissolved in physiological saline, stirred evenly, a...

Embodiment 3

[0042] Experimental animals: Kunming mice, male, weighing 20±2g.

[0043] 1. Forced mice to swim

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Abstract

The invention belongs to the technical field of preparation of medicine, and discloses a preparation process of tablets for treating depression. The preparation process comprises the following steps:step (1) preparing radix ginseng extract; step (2) preparing dried orange peel extract; step (3) preparing rhizoma rehmanniae extract; and step (4) granulating, arranging, tabletting, and coating. Thetablets prepared in the preparation method of the invention is appropriate in size, flat and smooth in appearance, low in cost, good in hardness and disintegration, and stable in quality.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to a preparation process of a tablet for treating depression. Background technique [0002] Depression or depressive disorder is a major global mental health problem. Its etiology is very complicated and has not yet been fully elucidated. With the increasing competition in modern society, people's psychological pressure continues to increase. Emotional diseases have become the main diseases of the contemporary world. According to the World Health Organization, the biggest disease facing people in the 21st century is mental illness. At present, the chemical drugs used to treat depression in the world mainly include tricyclic antidepressants, such as nortriptyline and desipramine, and monoamine oxidase inhibitors, such as phenelzine, tranylcypromine and isofazila etc., selective 5-HT reuptake inhibitors, such as fluoxetine, fluvoxam, sertraline, etc., and the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/30A61P25/24
CPCA61K36/258A61K9/2059A61K9/282A61K36/752A61K36/804A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 林凡友姚其胜咸永胜
Owner 仁和堂药业有限公司
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