Pharmaceutical composition containing pokeberry antiviral proteins and immunologic active material and applications thereof

Abstract

The invention discloses a pharmaceutical composition containing pokeberry antiviral proteins and an immunologic active material. The pharmaceutical composition comprises 0.001 to 10 wt% of pokeberry antiviral proteins and 0.1 to 60 wt% of immunologic active material, which is composed of one or more of algal polysaccharides, a cordyceps sinensis extract, a lucid ganoderma extract, propolis, aloe gel powder, polyinosinic acid-polycytidylic acid, and coconut oil. The pharmaceutical composition can effectively treat intraepithelial neoplasia of lower genital tracts of women and is a novel drug for the patients and doctors.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a pharmaceutical composition, in particular to a pharmaceutical composition containing pokeweed antiviral protein and immune active substances and its new application. The pharmaceutical composition can treat female lower genital tract intraepithelial neoplasia, Facilitate outcomes. Background technique [0002] Female lower genital tract intraepithelial neoplasia, including cervical intraepithelial neoplasia (CIN), vaginal intraepithelial neoplasia (VAIN), vulvar intraepithelial neoplasia (VIN), three Lesions in different parts can exist at the same time. [0003] According to the degree and extent of atypical hyperplasia, cervical intraepithelial neoplasia (CIN) is divided into grades I, II, and III. CIN I (called mild dysplasia of cervical epithelium): mild cellular atypia, manifested as enlarged nucleus in the lower 1 / 3 layer of the epithelial layer, slightly increased nucleocytoplasm...

AI Technical Summary

Problems solved by technology

Although physical therapy is effective, there are disadvantages such as increased vaginal secretions for a long time after surgery, large trauma, a large amount of watery discharge and scab bleeding, long wound healing time, high recurrence rate, and high cost. receiving physical therapy

At the same time, trauma sometimes leaves permanent scars, which may lead to atresia of secretory glands, changes in cervical mucus, infertility, or obstruction of cervical dilatation during childbirth, leading some patients to refuse treatment due to their desire for fertility or fear of surgery

In addition to CIN and VIN, for VAIN patients, the current clinical effects of physical therapy such as surgery or laser are not ideal

In addition, three different lesions of CIN, VAIN and VIN can also exist at the same time, and physical therapy such as surgery is not ideal for the treatment of patients with the combination of two or three lesions of CIN, VAIN and VIN

[0009] Pokeweed antiviral proteins (pokeweed antiviral proteins, PAPs) are one of the active ingredients in pokeweed, and PAPs have antiviral effects. The pharmaceutical composition of pokeweed antiviral proteins and immune active substances is used in female lower genital tract epithelium There is no report on the treatment of internal neoplasia, especially in patients with VAIN and patients with two or three lesions of CIN, VAIN and VIN.

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