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A biotissue detection device based on space offset Raman spectroscopy

A Raman spectroscopy and biological tissue technology, applied in the field of medical detection, can solve the problems of long-term preservation, etc., and achieve the effects of easy control, high precision and high sensitivity

Active Publication Date: 2021-01-29
中科凯利仪器设备(苏州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Similarly, its samples require special preparation and cannot be stored for a long time

Method used

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  • A biotissue detection device based on space offset Raman spectroscopy
  • A biotissue detection device based on space offset Raman spectroscopy
  • A biotissue detection device based on space offset Raman spectroscopy

Examples

Experimental program
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Embodiment 1

[0033] to combine Figure 1-3 , this embodiment specifically describes the device of the present invention.

[0034] A portable biological tissue detection device based on space offset Raman spectroscopy technology, including a computer 1, a detection controller 2, an excitation light module 3, a laser 301, a spectroscopic module 4, a spectrometer 401, a three-degree-of-freedom mechanical arm 5, and SORS detection Head 6, detection platform 7, airtight sample chamber 8; excitation light module 3 includes laser 301, focusing lens 302, coupler 303, incident optical fiber 304, spectroscopic module 4 includes spectrometer 401, collecting optical fiber 402; It is characterized in that, the computer 1 is respectively connected with the detection controller 2, the laser 301, and the spectrometer 401. The laser 301 emits laser light and is coupled into the incident optical fiber 304 through the coupler 303 behind the focusing mirror 302. The incident optical fiber 304 is connected to th...

Embodiment 2

[0048] The method of using the device of the present invention will be described in detail below. In this embodiment, a human tissue sample is detected.

[0049] Firstly, the sample to be tested is obtained, that is, the tissue sample taken from the lesion of the human body is subjected to preliminary pretreatment, and the pretreatment includes cleaning and stripping off non-detection substances.

[0050] Reshape the pretreated sample to make it comparable to the shape of the holding tank.

[0051] Prepare noble metal nanoparticle colloids, the preparation method of the noble metal nanoparticle colloids adopts the laser liquid phase ablation method, the diameter of the noble metal nanoparticles in the prepared noble metal nanoparticle colloids is about 50-200nm, and the noble metal nanoparticle colloids except noble metal nanoparticle The particles and water do not contain other impurities;

[0052] Mix the raw tissue with the noble metal nanoparticle colloid and then sonicat...

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Abstract

The invention belongs to the field of medical detection, and in particular relates to a portable biological tissue detection device based on space offset Raman spectroscopy technology. Including computer, detection controller, laser, spectrometer, three-degree-of-freedom robotic arm, SORS detection head, detection platform, and airtight sample chamber. The invention uses SORS technology to seal the sample to be tested, and can directly use equipment to detect its Raman spectrum while storing it away from light, so as to detect it; the combination of SORS technology and SERS technology solves the problem of SORS detection of biological sample signals Low defects, and at the same time solve the defect that the SERS detection sample can only detect the information; design a new SORS detection head, the detection head has high detection sensitivity, easy to control, and the precision of the control displacement is high, not affected by the precision of the stepping motor impact; a new type of biological sample storage device is designed, which can store samples for a long time and can detect SORS signals at any time.

Description

technical field [0001] The invention belongs to the field of medical detection, and relates to a biological tissue detection device, in particular to a portable biological tissue detection device based on space offset Raman spectroscopy technology. Background technique [0002] In modern medical testing, biological tissue testing is an important way for medical diagnosis. Since changes in biological tissue will lead to changes in its internal tissue composition, by detecting biological tissue, obtaining information about its composition, and comparing it with healthy and diseased tissue composition information, the health status of the organism can be further determined. [0003] Raman spectroscopy is a useful tool for analyzing molecular structure. The characteristic peak position, intensity and line width of Raman spectrum can provide information on molecular vibration and rotation, reflecting different chemical bonds or functional groups. As a non-destructive, non-conta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 王复超付倩倩刘晓明张建帅
Owner 中科凯利仪器设备(苏州)有限公司
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